Impact of gastrectomy on body composition within 1 month in patients with gastric cancer

Osaki, Tomohiro; Matsunaga, Tomoyuki; Makinoya, Masahiro; Shishido, Yuji; Miyatani, Kozo; Uchinaka, Ei; Tada, Yoichiro; Ashida, Keigo; Tatebe, Shigeru; Fujiwara, Yoshiyuki

doi:10.1007/s00595-022-02633-1

Cited by 3 publications

(2 citation statements)

References 31 publications

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“…Nevertheless, multivariate analysis revealed that LPG was an independent factor for severe weight loss 1 year after surgery. Similarly, a previous report suggested that when patients underwent radical resection, postoperative weight loss was more strongly influenced by surgical procedures than by tumor‐related factors 47,48 . Furthermore, as adjuvant chemotherapy was generally completed up to 1 year postoperatively, it does not affect after 1 year; however, in this study, the same degree of superiority of LPG over LTG in postoperatively weight loss was still observed after 1 year and thereafter.…”

Section: Discussionsupporting

confidence: 63%

Comparing the outcomes of laparoscopic proximal and laparoscopic total gastrectomy: A retrospective analysis of a single center in Japan

Aizawa,

Yabusaki,

Aoki

et al. 2023

Asian J Endoscop Surgery

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IntroductionDespite the increasing performance of laparoscopic proximal gastrectomy (LPG) for proximal gastric cancer and esophagogastric junction cancer, the benefit of LPG over laparoscopic total gastrectomy (LTG) remains to be established. Therefore, this study was conducted to compare postoperative outcomes between LPG and LTG.MethodsData from 141 patients who underwent LPG or LTG for gastric neoplasm with curative intent between 2016 and 2022 were retrospectively reviewed. Clinicopathological findings, body weight changes, and serological nutritional markers during the postoperative course were evaluated.ResultsLPG and LTG were performed in 78 patients and 63 patients, respectively. Patients' characteristics did not differ; however, tumor stages in patients who underwent LTG were more advanced than those who underwent LPG. The mean (± standard deviation) weight loss rate after 1 year was −13.5 (±6.9)% and −18.7 (±6.6)% for LPG and LTG, respectively (p < .01). LTG (OR: 3.326, p < .01), pT disease (OR: 3.000, p = .01), pN disease (OR: 2.708, p = .02), and postoperative chemotherapy (OR: 2.488, p = .05) were correlated with severe weight loss (16% or more) 1 year after surgery, then multivariate analysis identified LTG as an independent factor (p = .01). The mean (± standard deviation) serum total protein level of LPG was significantly higher than that of LTG at 3 months (6.8 ± 0.5 vs. 6.6 ± 0.4 g/dL, p = .02) and 1 year (6.9 ± 0.4 vs. 6.7 ± 0.5 g/dL, p = .01) postoperatively. No difference was observed in postoperative serum hemoglobin and albumin levels.ConclusionLPG more improved postoperative weight loss than LTG.

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Section: Discussionsupporting

confidence: 63%

Comparing the outcomes of laparoscopic proximal and laparoscopic total gastrectomy: A retrospective analysis of a single center in Japan

Aizawa,

Yabusaki,

Aoki

et al. 2023

Asian J Endoscop Surgery

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“…BIA is widely used as it is a simple and non-invasive method that provides accurate results [19,20]. Several reports have evaluated postoperative changes in body composition using BIA and analyzed the risk factors for postoperative complications in patients with gastric cancer [21][22][23]. Moreover, in patients with colorectal cancer, a preoperative low SMI based on the BIA method was considered a risk factor for postoperative ileus [24], and preoperative visceral fat area measured by BIA was an independent prognostic factor for disease-free survival [25].…”

Section: Discussionmentioning

confidence: 99%

Effect of body fat mass loss on prognosis of radical resection for pancreatic ductal adenocarcinoma based on bioelectrical impedance analysis

Shibata,

Sudo,

Tazuma

et al. 2023

Preprint

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Background Few reports have performed a prognostic analysis based on bioelectrical impedance analysis in patients with radical resection of pancreatic ductal adenocarcinoma (PDAC), and its usefulness in prognostic analysis remains unclear. This study aimed to evaluate body composition changes in patients undergoing radical resection for PDAC and analyze its impact on prognosis. Methods The medical records of radical resection for patients with PDAC were retrospectively reviewed, and the parameters of body composition, including body weight, skeletal muscle mass, body fat mass (BFM), and extracellular water-total body water ratio, from preoperatively to 12 months postoperatively, for each surgical procedure were measured based on direct segmental multifrequency bioelectrical impedance analysis with an InBody 770 (InBody Inc., Tokyo, Japan) device. The clinicopathological and prognostic factors were analyzed. Results Among 79 patients who underwent radical resection for PDAC, 36 (46%), 7 (8%), and 36 (46%) underwent pancreatoduodenectomy, total pancreatectomy, and distal pancreatectomy, respectively. The multivariate overall survival analysis demonstrated that BFM loss percentage at 1 month postoperatively ≧ 14% (p = 0.021), lymph node metastasis (p = 0.014), and non-adjuvant chemotherapy (p < 0.001) were independent poor prognostic factors. Multivariate analysis revealed that preoperative BFM < 12 kg and preoperative albumin < 3.5 g/dL were independently associated with BFM loss percentage at 1 month postoperatively ≧ 14% (p = 0.016 and p = 0.047, respectively). Conclusions Loss of BFM in the early postoperative period may have a poor prognosis in radical resection of PDAC.

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Effect of body fat mass loss on prognosis of radical resection for pancreatic ductal adenocarcinoma based on bioelectrical impedance analysis

Shibata,

Sudo,

Tazuma

et al. 2024

BMC Surg

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Background Few reports have performed a prognostic analysis based on bioelectrical impedance analysis in patients with radical resection of pancreatic ductal adenocarcinoma (PDAC), and its usefulness in prognostic analysis remains unclear. This study aimed to evaluate body composition changes in patients undergoing radical resection for PDAC and analyze its impact on prognosis. Methods The medical records of radical resection for patients with PDAC were retrospectively reviewed, and the parameters of body composition, including body weight, skeletal muscle mass, body fat mass (BFM), and extracellular water-total body water ratio, from preoperatively to 12 months postoperatively, for each surgical procedure were measured based on direct segmental multifrequency bioelectrical impedance analysis with an InBody 770 (InBody Inc., Tokyo, Japan) device. The clinicopathological and prognostic factors were analyzed. Results Among 79 patients who underwent radical resection for PDAC, 36 (46%), 7 (8%), and 36 (46%) underwent pancreatoduodenectomy, total pancreatectomy, and distal pancreatectomy, respectively. The multivariate overall survival analysis demonstrated that BFM loss percentage at 1 month postoperatively ≧14% (p = 0.021), lymph node metastasis (p = 0.014), and non-adjuvant chemotherapy (p < 0.001) were independent poor prognostic factors. Multivariate analysis revealed that preoperative BFM < 12 kg and preoperative albumin < 3.5 g/dL were independently associated with BFM loss percentage at 1 month postoperatively ≧14% (p = 0.021 and p = 0.047, respectively). Conclusions Loss of BFM in the early postoperative period may have a poor prognosis in radical resection of PDAC.

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Impact of gastrectomy on body composition within 1 month in patients with gastric cancer

Cited by 3 publications

References 31 publications

Comparing the outcomes of laparoscopic proximal and laparoscopic total gastrectomy: A retrospective analysis of a single center in Japan

Comparing the outcomes of laparoscopic proximal and laparoscopic total gastrectomy: A retrospective analysis of a single center in Japan

Effect of body fat mass loss on prognosis of radical resection for pancreatic ductal adenocarcinoma based on bioelectrical impedance analysis

Effect of body fat mass loss on prognosis of radical resection for pancreatic ductal adenocarcinoma based on bioelectrical impedance analysis

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