Impact of gas-solid direct contact on gas-liquid-solid reaction performance in a flow reactor

Reductive N-Alkylation of Amines with Ketones Using Heterogeneous Polysilane–Palladium Catalysts under Continuous-Flow Conditions

“…Continuous-flow hydrogenation reactions with heterogeneous catalysts enhance reactivity due to the efficient and direct contact between the solid catalyst and H 2 gas. − While flow methods have been applied in reductive N-alkylation with H 2 and heterogeneous catalysts for ketones, including an asymmetric reaction, − harsh conditions and/or additives were often required to promote intermediate formation, and applicable substrates were limited. Our group previously established continuous-flow reductive N-alkylation using a heterogeneous Pt/C catalyst under relatively mild conditions; however, a high reaction temperature was still necessary when using a ketone substrate .…”