Impact of gadolinium on mechanical properties, corrosion resistance, and biocompatibility of Zn-1Mg-xGd alloys for biodegradable bone-implant applications

Tong, Xian; Zhu, Li; Wang, Kun; Shi, Zhanbiao; Huang, Shengbin; Li, Yuncang; Ma, Jianfeng; Wen, Cuie; Lin, Jixing

doi:10.1016/j.actbio.2022.02.015

Cited by 39 publications

(20 citation statements)

References 59 publications

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“…[ 16a ] In a recently reported study, 0.1–0.3 wt.% Gd are introduced into Zn‐1Mg alloy, which improves the cell viability of MG63 cells in 25% and 12.5% extracts. [ 30 ] Here, only 0.4 ng mL −1 Gd element was detected in extracts of Zn‐0.4Gd alloy, which is only one‐thirty thousandth of the zinc element content. Therefore, the biodegradation and releasing behavior of zinc element should be the main reason for the histological difference induced by these two implants.…”

Section: Discussionmentioning

confidence: 93%

Modified Biodegradation Behavior Induced Beneficial Microenvironments for Bone Regeneration by Low Addition of Gadolinium in Zinc

Yang

Jia

et al. 2022

Adv Healthcare Materials

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Zinc (Zn) shows a great potential as a biodegradable material for bone implants after a decade of systematic research and development. However, uncontrollable biodegradation behavior and biphasic dose-response prevent Zn from fulfilling its essential role in facilitating bone regeneration. In this study, the low addition of gadolinium (Gd) modifies the intrinsic microstructure of Zn in terms of grain size distribution, grain boundary misorientation, and texture. Adding Gd refines grain size distribution and creates a stronger basal plane texture in Zn, consequently, changing the current density distribution and reducing the anode dissolution rate during corrosion. As a result, uniform degradation is more predominant in Zn-0.4Gd alloy implant, in comparison to localized degradation in pure Zn implant in bone environments. The modified biodegradation behavior of the Zn-0.4Gd alloy implant induces significantly better new bone formation and osseointegration compared to the pure Zn implant. Therefore, Gd with trace amounts is able to tune the degradation behavior and improve the performance of Zn-based implants in promoting bone regeneration.

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Section: Discussionmentioning

confidence: 93%

Modified Biodegradation Behavior Induced Beneficial Microenvironments for Bone Regeneration by Low Addition of Gadolinium in Zinc

Yang

Jia

et al. 2022

Adv Healthcare Materials

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“…Although Mg is a physiologically essential element with good toleration; Mg alone cannot provide the implant with the desired mechanical strengths and degradation rate. Hence, these implants are mostly supplemented with other elements such as Gadolinium (Gd) [ [149] , [150] , [151] ] and Silver (Ag) [ [152] , [153] , [154] ], which can modulate immune cell function [ 57 ].…”

Section: Immune Response Differences Between Degradable and Non-degra...mentioning

confidence: 99%

Immune response differences in degradable and non-degradable alloy implants

Khodaei

Schmitzer

Suresh

et al. 2023

Bioactive Materials

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“…In addition, drug overuse easily drives drug resistance to infection, which has reached alarming proportions [ 30 ]. Moreover, conventional orthopaedic implant materials without antibacterial activity may easily lead to an inflammatory response and even infection [ 31 ], and should be concerned for the insufficient biocompatibility and non-degradability [ 32 ] ( Fig. 1 ).…”

Section: Introductionmentioning

confidence: 99%