Impact of frozen-thawed single-blastocyst transfer on maternal and neonatal outcome: an analysis of 277,042 single-embryo transfer cycles from 2008 to 2010 in Japan

Ishihara, Osamu; Araki, Ryuichiro; Kuwahara, Akira; Itakura, Atsuo; Saito, Hidekazu; Adamson, G. David

doi:10.1016/j.fertnstert.2013.09.025

Cited by 332 publications

(321 citation statements)

References 18 publications

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“…Since both maternal age and parity correlate with higher birth weight, LGA rate, and other maternal pathology, such as hypertension or placenta previa [3,[36][37][38][39] we matched the controls to the study groups in order to exclude the possible bias. According to Lintsen et al, the impact of smoking on the live birth rate in IVF treatment is comparable with an increase in female age of >10 years in young women [40].…”

Section: Discussionmentioning

confidence: 99%

“…The effect of embryo culture length on birth weight still remains a matter of debate. Prolonged embryo culture (days 5 and 6) has been linked to a higher LGA rate in comparison to day 2 or 3 ET in fresh ET singletons [3,25,37]. In contrast, others report an increased risk of low birth weight and preterm birth after blastocyst transfer [24,39].…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have shown that singletons born after FET have a perinatal outcome more comparable to those born after natural conception than to those born after fresh embryo transfer (fresh ET), having higher birth weight and less pregnancy complications [2][3][4][5][6][7][8][9][10]. However, higher risk for birth of a singleton being large for gestational age (LGA) has been revealed after FET [2,3,7,8,[11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

“…The influences of the culture media [21][22][23], culture period [24,25], hormonal protocols [26], and infertility [12,14,27] on the IVF singleton birth weight have already been considered. There are several studies confirming that IVF placentas differ from spontaneous placentas in their size, shape, weight, and abnormality rate [3,6,7,[28][29][30][31], and that placentation following FET differ from the placentation following fresh ET [3,6,7,13] In this study, we analyzed the connection of IVF procedure type and maternal background factors to LGA risk. The factors observed were the fertilization technique, ET type, number of embryos transferred, maternal age, smoking, hypertension, parity, BMI, and gestational diabetes mellitus (GDM).…”

Section: Introductionmentioning

confidence: 99%

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Independent factors influencing large-for-gestation birth weight in singletons born after in vitro fertilization

Korošec

Frangež

Steblovnik

et al. 2015

J Assist Reprod Genet

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Purpose Higher risk for birth of singletons being large for gestational age (LGA) has been revealed after in vitro fertilization (IVF) frozen-thawed embryo-transfer (FET). This phenomenon is now being investigated, since there is a speculation that these neonates could suffer from underlying epigenetic disturbances. The aim of the study was to expose independent LGA risk factors and to identify those connected to the IVF techniques. Methods Altogether, 4508 singleton pregnancies and births were included in the cohort case-matched study. Two hundred eleven singleton pregnancies and births after FET and 916 after fresh embryo transfer (ET) were included into two study groups. The IVF procedures were performed at the University Medical Centre Ljubljana between 2004 and 2011. For each IVF pregnancy, three matched consecutive controls after natural conception were included. Using logistic regression models, we observed LGA connection to maternal parameters (smoking, hypertension, parity, BMI, gestational diabetes, IVF conception, FET, double ET, and ICSI procedure).Results Singletons born after FET had a significantly higher risk for being LGA (p=0.032; OR 1.697; 95 % CI 1.047-2.752). BMI 25-30 was a significant independent risk factor for LGA in the IVF groups (FET p=0.041, OR 2.460, 95 % CI 1.030-5.857 and fresh ET p=0.003; OR 2.188, 95 % CI 1.297-3.691). ICSI and double ET had no significant effect on LGA occurrence. Conclusions Besides maternal BMI, FET is a significant independent LGA risk factor in IVF patients. Other observed factors (smoking, hypertension, multiparity, GDM, ICSI procedure, or number of embryos transferred) do not influence LGA risk significantly.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Independent factors influencing large-for-gestation birth weight in singletons born after in vitro fertilization

Korošec

Frangež

Steblovnik

et al. 2015

J Assist Reprod Genet

View full text Add to dashboard Cite

show abstract

“…As pregnancies that are achieved by ART treatments are associated with a higher incidence of a low birthweight,2, 7, 8, 9, 10, 11 repeat ART treatments are considered to be one of the risks that are attributed to preterm birth. However, it has been reported previously that the neonatal birthweight might be higher with the frozen‐thawed embryo transfer (ET) method than that with the fresh ET method 2, 12.…”

Section: Introductionmentioning

confidence: 99%

Birthweights and Down syndrome in neonates that were delivered after frozen‐thawed embryo transfer: The 2007‐2012 Japan Society of Obstetrics and Gynecology National Registry data in Japan

Yamatoya

Saito

et al. 2017

Reprod Medicine & Biology

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AimTo evaluate the use of frozen embryos on the outcome of assisted reproductive technology (ART), a retrospective study of the Japanese Assisted Reproductive Technology Registry data during the years 2007‐2012 was conducted.MethodsA total of 124 946 singleton neonates who reached term gestation following ART from 2007‐2012, with 80 660 achieved through frozen‐thawed embryo transfer (ET) and 44 286 being achieved through fresh ET, were analyzed for their birthweights and chromosomal abnormalities.ResultsThe birthweight of the neonates from the frozen‐thawed ETs was significantly higher than that of those from the fresh ETs throughout all the study years. The frequency of Down syndrome was 0.17% for the fresh ETs and 0.13% for the frozen‐thawed ETs in the period 2007‐2012. This study showed that frozen‐thawed ETs result in a constant increase of the average birthweight between 37 and 41 weeks gestational age and lower frequencies of Down syndrome.ConclusionFrozen‐thawed ETs were comparable to the fresh ET method, with the exceptions of higher birthweights and a lower frequency of Down syndrome in the neonates that were born from frozen‐thawed ET. The increase in birthweights was not proportional to the gestational ages. This cannot be explained with any well‐known mechanism. The frequency of chromosomal abnormalities needs detailed data for analysis.

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Fresh versus frozen embryo transfers in assisted reproduction

Zaat

Zagers

Mol

et al. 2021

Cochrane Database of Systematic Reviews

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Impact of frozen-thawed single-blastocyst transfer on maternal and neonatal outcome: an analysis of 277,042 single-embryo transfer cycles from 2008 to 2010 in Japan

Cited by 332 publications

References 18 publications

Independent factors influencing large-for-gestation birth weight in singletons born after in vitro fertilization

Independent factors influencing large-for-gestation birth weight in singletons born after in vitro fertilization

Birthweights and Down syndrome in neonates that were delivered after frozen‐thawed embryo transfer: The 2007‐2012 Japan Society of Obstetrics and Gynecology National Registry data in Japan

Fresh versus frozen embryo transfers in assisted reproduction

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