2020
DOI: 10.1007/s00404-020-05807-9
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Impact of frailty on the management of patients with gynecological cancer aged 80 years and older

Abstract: Purpose To assess the impact of frailty on compliance of standard therapy, complication, rate and survival in patients with gynecological malignancy aged 80 years and older. Methods In total, 83 women with gynecological malignancy (vulva, endometrial, ovarian or cervical cancer) who underwent primary treatment between 2007 and 2017 were retrospectively analyzed. Frailty index was calculated and its association with compliance of standard treat… Show more

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Cited by 10 publications
(7 citation statements)
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“…Fifteen studies were speci cally conducted in the medical oncology setting, 19,20,23,24,[26][27][28][29][33][34][35]38,43,51,54 eight studies in surgical oncology, 41,42,45,49,52,53,55,56 and the remainder were either mixed or not speci ed. 17,18,22,25,[30][31][32]36,37,39,40,44,[46][47][48]50,57,58 Fourteen studies included a range of cancers and the rest focused on individual cancer types.…”
Section: Study Characteristicsmentioning
confidence: 99%
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“…Fifteen studies were speci cally conducted in the medical oncology setting, 19,20,23,24,[26][27][28][29][33][34][35]38,43,51,54 eight studies in surgical oncology, 41,42,45,49,52,53,55,56 and the remainder were either mixed or not speci ed. 17,18,22,25,[30][31][32]36,37,39,40,44,[46][47][48]50,57,58 Fourteen studies included a range of cancers and the rest focused on individual cancer types.…”
Section: Study Characteristicsmentioning
confidence: 99%
“…20,[22][23][24][25]30,32,36,39,40,44,46,47,50,57,58 There were 10 studies of breast cancer, [17][18][19][26][27][28][29]33,37,56 of which six studies were different secondary analyses of the same prospective clinical trial. 19,26,27,33 Similarly, two 34,51 of the ve lung cancer studies utilised the same retrospective database, 34,35,48,49,51 as did three [53][54][55] of four studies of gynaecological cancers, 45,[53][54][55] and both studies of pancreatic cancer. 30,31 Four studies evaluated gastrointestinal cancers, 23,38,41,42 and one was speci cally evaluated participants with meningiomas.…”
Section: Study Characteristicsmentioning
confidence: 99%
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“…2 The impact of older age on perioperative outcomes and treatment-related toxicities in women with ovarian cancer has been well-described. [3][4][5][6][7][8][9][10][11] While historically older patients were considered to have decreased tolerance for surgical and medical management, recent data supports that other factors aside from chronological age, including medical comorbidities and nutritional status, should be considered in treatment planning. [12][13][14][15][16][17][18][19][20][21][22][23][24][25] Notably, studies have demonstrated that older women may be less likely to receive standard front-line management for ovarian cancer, leading to worse overall survival.…”
Section: Introductionmentioning
confidence: 99%
“…Elderly female patients, especially elderly patients with gynaecological malignancies, have a relatively high incidence of perioperative complications due to their poor physical function, wide scope of operation, and adverse psychological effects [ 2 ]. It was reported that the incidence of postoperative complications in elderly patients with malignant gynaecological tumours can reach more than 30%, and the incidence of lower extremity deep venous thrombosis (LEDVT) accounts for more than one-third of these complications [ 3 ]. Therefore, it is essential to implement interventions to reduce the poor prognosis of elderly patients with gynaecological malignancies.…”
Section: Introductionmentioning
confidence: 99%