Impact of four direct oral anticoagulants on rotational thromboelastometry (ROTEM)

Seyve, Landry; Richarme, Claire; Polack, Benoı̂t; Marlu, Raphaël

doi:10.1111/ijlh.12744

Cited by 64 publications

(87 citation statements)

References 24 publications

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“…Previously, our group showed that whole blood thromboelastometry assessment using a low TF concentration was sensibly influenced by LMWH and fondaparinux 22, 23. However, when the test was performed in the presence of high TF concentration (EXTEM) or contact system activator (INTEM) was less sensitive to the activity of these agents 24, 25…”

Section: Discussionmentioning

confidence: 99%

“…22,23 However, when the test was performed in the presence of high TF concentration (EXTEM) or contact system activator (INTEM) was less sensitive to the activity of these agents. 24,25 Comparison of the data obtained by thrombin generation assessment in PPP or PRP with those obtained by the thromboelastometric study in whole blood shows that the delay in clot formation is principally linked to the prolongation of the initiation phase of thrombin generation and to the delay of the propagation phase.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of antithrombin‐dependent and direct inhibitors of factor Xa or thrombin on the kinetics and qualitative characteristics of blood clots

Salta

Papageorgiou

Larsen

et al. 2018

Research and Practice in Thrombosis and Haemostasis

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BackgroundVenous thromboembolism (VTE) is associated with significant morbidity and mortality.ObjectivesWe investigated the impact of direct and AT‐dependent FXa or thrombin inhibitors on thrombus formation.MethodsWhole blood thromboelastometry and thrombin generation were assessed after triggering the TF pathway. Clinically relevant concentrations of rivaroxaban, fondaparinux, dabigatran or tinzaparin and an association of rivaroxaban and dabigatran were examined.ResultsAll agents delayed thrombus formation in a concentration‐dependent manner, as documented by the prolongation of the clotting time (CT) and clot formation time (CFT). Rivaroxaban did not significantly alter the α‐angle or maximum clot firmness (MCF). In contrast, dabigatran and fondaparinux altered the process of clot structure by decreasing the α‐angle, but did not modify clot firmness. The later property was significantly affected only by tinzaparin that also reduced the MCF. The association of rivaroxaban and dabigatran did not affect the MCF, although it amplified the effect on CFT and α‐angle.ConclusionsAll agents delayed thrombus formation. However, the compounds differed substantially with respect to fibrin polymerization rate and clot firmness. Comparison of the data obtained by thrombin generation assessment with those obtained by the thromboelastometric study shows that the delay in clot formation is principally associated with prolongation of the initiation phase of thrombin formation as well as a reduction of the propagation phase. Tinzaparin was much more potent than the other agents both with regard to suppression of thrombin generation and by delay in clot formation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Comparison of antithrombin‐dependent and direct inhibitors of factor Xa or thrombin on the kinetics and qualitative characteristics of blood clots

Salta

Papageorgiou

Larsen

et al. 2018

Research and Practice in Thrombosis and Haemostasis

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“…Viscoelastic haemostatic assays tests are generally insensitive to anti‐platelet agents (except α2bβ3 blockers) (Tynngård et al , ). Standard ROTEM tests (EXTEM/INTEM CT) can detect DOACs (dabigatran, edoxaban, rivaroxaban) at therapeutic levels, but appear insensitive to apixaban (Seyve et al , ). Sonoclot measures are set out in Fig .…”

Section: Vha Tracesmentioning

confidence: 99%

The use of viscoelastic haemostatic assays in the management of major bleeding

et al. 2018

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“…Normally, vWF binds to coagulation factor VIII and forms a stable inactive complex. In AVWS-2A, clot formation is impaired by dysfunctional interaction between platelets and the blood coagulation system even with normal factor VIII activity and the absence of abnormalities in PT or APTT [4,5].…”

Section: Introductionmentioning

confidence: 99%

Rotational thromboelastometry-guided perioperative management of coagulation in a patient with Heyde’s syndrome undergoing transcatheter aortic valve implantation

et al. 2019

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Background: Changes in coagulability during the hyperacute phase within 24 h after transcatheter aortic valve implantation (TAVI) for Heyde's syndrome, or aortic stenosis complicated by gastrointestinal angiodysplasia and acquired coagulation dysfunction, have not been clarified. We evaluated perioperative changes in coagulability using rotational thromboelastometry (ROTEM). Case presentation: A female patient with Heyde's syndrome in her 80s underwent TAVI. ROTEM showed coagulation dysfunction before and at 6 h after surgery. Improvements in coagulation function started at 12 h after surgery. Based on ROTEM findings, oral administration of antiplatelet agents was started on the day after surgery. No hemorrhagic complications were observed in the postoperative phase. Conclusions: Evaluation of coagulation function using ROTEM was useful for monitoring perioperative hemostasis and coagulation in this patient.

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Impact of four direct oral anticoagulants on rotational thromboelastometry (ROTEM)

Abstract: Introduction: Rotational Thromboelastometry (ROTEM) is a point of care method

Cited by 64 publications

References 24 publications

Comparison of antithrombin‐dependent and direct inhibitors of factor Xa or thrombin on the kinetics and qualitative characteristics of blood clots

Comparison of antithrombin‐dependent and direct inhibitors of factor Xa or thrombin on the kinetics and qualitative characteristics of blood clots

The use of viscoelastic haemostatic assays in the management of major bleeding

Rotational thromboelastometry-guided perioperative management of coagulation in a patient with Heyde’s syndrome undergoing transcatheter aortic valve implantation

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