Impact of first COVID‐19 lockdown on paediatric and adult haemophilia patients treated in a French Haemophilia Comprehensive Care Centre

Volot, Fabienne; Soudry-Faure, Agnès; Callegarin, Anamaria; Ksiazek, Eléa; Delienne, Stephanie; Cottin, Yves; Maynadié, Marc; Boulin, Mathieu

doi:10.1111/hae.14526

Cited by 5 publications

(4 citation statements)

References 23 publications

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“…The analysis of the main study variables during the COVID-19 pandemic, by lockdown period, although limited by variability in the number of evaluable patients in each period, contributes to a better understanding of the impact of the strict social and activity limitations adopted by the Italian government during the pandemic. Differently from other studies depicting a decrease in PA among adolescents and young adults during the first COVID-19 lockdown in the Netherlands [ 37 ], Norway [ 9 ], and France [ 38 ], our study did not reveal any impact on the PA recorded both in the first and second lockdown. It is important to consider that the observation period in our ad hoc analysis was longer, all data related to PA were monitored (not only sports), and the data collection solution was more accurate despite the e-survey.…”

Section: Discussioncontrasting

confidence: 99%

“…It is important to consider that the observation period in our ad hoc analysis was longer, all data related to PA were monitored (not only sports), and the data collection solution was more accurate despite the e-survey. On the other hand, our results confirm those from other studies revealing that patients’ well-being and lifestyle, treatment adherence, bleeding frequency, pain, and painkiller use were not affected by the pandemic [ 9 , 36 , 38 ].…”

Section: Discussionsupporting

confidence: 90%

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Physical Activity, Bleedings and Quality of Life in Subjects with Haemophilia A without Inhibitors—A Multicenter, Observational Italian Study with a Wearable Device

Mancuso,

Biasoli,

Marino

et al. 2024

JCM

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Background: This study aimed to gather data on physical activity (PA), bleeding, health-related quality of life, and health status, using a wearable device and an electronic patient-reported outcome (ePRO) app, in individuals with moderate or severe hemophilia A (HA) without inhibitors receiving treatment according to the clinical practice. Methods: This is a 12-month multicenter cohort study conducted in Italy. The primary outcomes included the description of PA by type and intensity, adherence to World Health Organization guidelines, bleeding, and health-related quality of life by EQ-5D questionnaire. PA data were collected continuously through a fitness tracker worn by the patient; all the other variables were collected through ePRO questionnaires. Results: Only 54 of the 103 enrolled subjects (52.4%) used their fitness tracker for the defined valid period; adolescents were the least compliant age group. PA was performed at low rates and intensity. Approximately 52% of the subjects had sedentary behavior. The mean EQ-5D values did not change over time. At least one bleeding was reported in 43.7% of the subjects, mostly with sedentary behavior. The PA in the 2 days preceding the bleeding was comparable to the one observed in the overall observational period. Conclusions: The systematic recording of data through a fitness tracker and ePRO app shows that subjects with HA without inhibitors have lower-than-expected PA and that they still experience issues related to bleeding.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 90%

Physical Activity, Bleedings and Quality of Life in Subjects with Haemophilia A without Inhibitors—A Multicenter, Observational Italian Study with a Wearable Device

Mancuso,

Biasoli,

Marino

et al. 2024

JCM

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“…Our results showed a decrease in PA among PWH in March‐May 2020, which is natural, since this coincides with the first COVID‐19 lockdown in Norway, when strict social and activity restrictions were imposed, including closing of gyms and schools. Decreased PA of PWH during this period has also been reported from surveys in the Netherlands and France 42,43 …”

Section: Discussionsupporting

confidence: 69%

Physical activity in Norwegian teenagers and young adults with haemophilia A compared to general population peers

et al. 2023

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Introduction: Limited evidence exists on objectively measured habitual physical activity (PA) of young people with haemophilia (PWH).Aims: To compare different outcomes of objective PA between young PWH A and controls using a commercial activity tracker. Methods:We enrolled males aged 13-30 years with moderate and severe haemophilia A, without inhibitors on regular prophylaxis. PA was measured with the activity tracker Fitbit Charge 3 for 12 weeks. Control group data was obtained from ≈60,000 Fitbit users, matched on age, sex and measurement period. PA variables [steps, intensities, volume, activity types, exercise frequencies and proportion meeting the World Health Organization's moderate-to-vigorous PA (MVPA) recommendations] were compared between groups descriptively and using Welch's two-sample t-test and two-sample test of proportions.Results: Forty PWH A were enrolled (mean age 19.5 years, 50% teenagers, 50% adults, three (7.5%) with moderate and 37 (92.5%) with severe haemophilia). Mean daily steps and minutes MVPA were similar between PWH and controls. PWH spent more time in light PA (mean 227 vs. 192 min/day, P = .033) and exercised more frequently (mean 5.6 vs. 3.9 exercise sessions/week, P < .001). Among teenagers, 40% PWH and 8% controls reached MVPA recommendations, compared to 95% and 100% among adults. The most common type of PA was walking. Conclusion:This cohort of young PWH A on prophylactic treatment had PA levels comparable to controls. Still, a considerable proportion of teenagers did not meet the recommended weekly volume of MVPA, and we encourage clinicians to have a particular focus on promoting PA for this group.

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“…Studies have shown that the COVID-19 pandemic had a negative impact on lifestyle behaviors, routine care, and replacement therapies in patients with CBD [15][16][17][18]. However, there are only a limited number of clinical studies that have investigated the outcomes of COVID-19 in patients with bleeding disorders, and it is not known whether patients with bleeding disorders are more or less prone to the severe form of infection.…”

Section: Discussionmentioning

confidence: 99%

Outcomes of COVID-19 in Adult Males With Hemophilia A: A Propensity Score-Matched Analysis

Mericliler¹,

Narayan²

2022

Cureus

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BackgroundHypercoagulability is a major pathologic event in COVID-19. Factor VIII plays an important role in hemostasis, and high levels of factor VIII have been shown to be associated with an increased risk of thrombosis and severe disease. Little is known about the impact of COVID-19 on clinical outcomes in patients with hemophilia A. MethodologyRetrospective data of adult male patients with COVID-19 with and without hemophilia A were retrieved from the TriNetX database (Cambridge, USA). The 1:1 propensity score-matching was performed to balance baseline characteristics. Patients were matched for age, race, body mass index, and medical comorbidities. Thirty-day outcomes were assessed. ResultsWe identified 1,758 patients with pre-existing hemophilia A diagnosis prior to COVID-19 diagnosis and 5,191,908 comparators. After 1:1 propensity score matching, groups were balanced on demographics and comorbidities. All-cause mortality rates were similar between the two groups (HR 0.805; 95% CI 0.467-1.389). The frequency of severe infection, ICU admission, and composite thrombotic events did not differ between the groups. Patients with hemophilia A were hospitalized more frequently than those without a history of hemophilia A (19.2% vs. 14.4%; p<0.05). Additionally, gastrointestinal (GI) bleeding and composite bleeding events occurred more frequently in patients with hemophilia A (3.2% vs. 2.2%; p<0.05 and 4.0% vs. 2.8%; p<0.05, respectively). ConclusionsThe mortality of individuals with hemophilia A due to COVID-19 is comparable to the general population but with higher risks of hospitalization and bleeding.

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Impact of first COVID‐19 lockdown on paediatric and adult haemophilia patients treated in a French Haemophilia Comprehensive Care Centre

Cited by 5 publications

References 23 publications

Physical Activity, Bleedings and Quality of Life in Subjects with Haemophilia A without Inhibitors—A Multicenter, Observational Italian Study with a Wearable Device

Physical Activity, Bleedings and Quality of Life in Subjects with Haemophilia A without Inhibitors—A Multicenter, Observational Italian Study with a Wearable Device

Physical activity in Norwegian teenagers and young adults with haemophilia A compared to general population peers

Outcomes of COVID-19 in Adult Males With Hemophilia A: A Propensity Score-Matched Analysis

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