Impact of fermented brown rice with Aspergillus oryzae (FEBRA) intake and concentrations of polybrominated diphenylethers (PBDEs) in blood of humans from Japan

Takasuga, Takumi; Senthilkumar, K.; Takemori, Hiroaki; Ohi, Etsumasa; Tsuji, Hiroshi; Nagayama, Junya

doi:10.1016/j.chemosphere.2004.07.016

Cited by 40 publications

(29 citation statements)

References 27 publications

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“…However, when they are, DBDE and other high molecular weight PBDE are major contaminants [14]. For instance, in humans, the presence of DBDE has been reported in mother's milk [15], serum [16,17] and adipose tissue [14,18,19]. These conclusions are also supported by recent data obtained in rat using radio-labeled [ 14 C]-DBDE [20,21], which demonstrate that DBDE bioavailability is above 20%.…”

supporting

confidence: 78%

Time-of-flight secondary ion mass spectrometry imaging demonstrates the specific localization of deca-bromo-diphenyl-ether residues in the ovaries and adrenal glands of exposed rats

Seyer

Riu²,

Debrauwer³

et al. 2010

J. Am. Soc. Mass Spectrom.

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Deca-bromo-diphenyl ether (DBDE) is one of the most efficient brominated flame retardant (BFR) available on the market. We recently demonstrated that when administered to female rat by oral route, DBDE is efficiently absorbed, with the highest residual concentrations found in two endocrine glands, namely the adrenal glands and the ovaries. Time-of-flight secondary ion mass spectrometry (TOF-SIMS) imaging, a technique usually used for the study of endogenous compounds, was applied for the first time to a persistent organic pollutant, allowing to detect and to precisely localize DBDE residues in these two target tissues. The detection of the bromide ion ( 81 Br isotope) by TOF-SIMS mass spectrometry imaging allowed us to demonstrate a marked cortical tropism of DBDE residues for the adrenal glands in female rats dosed per os 2 mg · kg Ϫ1 DBDE, daily, over 96 h. In ovaries, DBDE residues were found to be concentrated in spots corresponding to part of the corpora lutea. Hepatic residues of DBDE were found to be homogeneously distributed. Due to the intrinsic toxicity of DBDE, its accumulation in the adrenal glands and the ovaries may be connected to the mechanisms of actions by which DBDE could trigger endocrine disruption in mammals. (J Am Soc Mass

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supporting

confidence: 78%

Time-of-flight secondary ion mass spectrometry imaging demonstrates the specific localization of deca-bromo-diphenyl-ether residues in the ovaries and adrenal glands of exposed rats

Seyer

Riu²,

Debrauwer³

et al. 2010

J. Am. Soc. Mass Spectrom.

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“…3, from which it can be seen that the concentration of PBDEs in human blood has increased rapidly in recent years. High levels of deca-BDE (up to 13 ng g − 1 , lipid weight) were determined in Japanese human blood collected in 2004 (Takasuga et al, 2001), which contrasts with the previous reports that found 99, and 153 to be prevalent. Possible sources for the more recent prevalence of deca-BDE are food and computer rich environments, such as offices and game rooms (de Boer et al, 1999).…”

Section: Pbdes In Human Samplescontrasting

confidence: 47%

Polybrominated diphenyl ether in the East Asian environment: A critical review

Wang

Jiang

Lam

et al. 2007

Environment International

221

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Polybrominated diphenyl ethers (PBDEs) have been extensively used as flame retardants in consumer goods. Sufficient evidence shows that PBDEs have been rapidly accumulating in the environment worldwide. In Asia, deca-bromodiphenyl ether has been produced and used in large quantities, while penta-BDE has largely ceased in the mid-1990s. This paper summarizes and critically reviews the status of PBDE pollution in East Asia, with emphases on the comparisons with Europe and North America and the interpretation of the differences. In general, the concentrations of PBDEs in atmosphere, sludge, human and biological samples of East Asia are comparable to or lower than those in Europe and North America. However, in the sediments of waters near densely populated and heavily industrialized areas, PBDE levels are among the highest ever reported in the literature. In Japan and China, concentrations of PBDEs in sediment cores showed an increasing trend for the past 20-30 years. Also, PBDEs levels in human breast milk in Japan increased about 10-fold in the past 20 years. The presence of PBDEs in fur seal has increased about 150-fold in 1994 than that in 1972. Regional and inter-continental transport cannot be confirmed due to insufficient information. However, the detection of a number of PBDE congeners in a pristine lake on the Qinghai-Tibet Plateau may be an evidence of their long-range transport.

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“…Takasuka et al (2004a) studied biological elimination of persistent organic pollutants in humans via intake of fermented brown rice with Aspergillus oryzae (Takasuga et al, 2004a). After two years of consumption, those who ate the fermented brown rice had greater elimination of PCDD/Fs than those who did not, although the former group showed slightly higher serum PBDE concentrations (Takasuga et al, 2004b). In 18 serum samples from nine couples aged 37-48 years in Japan, selected organochlorine pesticides were identified by gas chromatography-high resolution mass spectrometry to assess the impact of intake of fermented brown rice with Aspergillus oryzae on biological elimination of organochlorine pesticides (Takasuga et al, 2006).…”

Section: Japanmentioning

confidence: 99%