Impact of FDG-PET on radiation therapy volume delineation in non–small-cell lung cancer

Bradley, Jeffrey D.; Thorstad, Wade L.; Mutic, Sasa; Miller, Tom R.; Dehdashti, Farrokh; Siegel, Barry A.; Bosch, Walter; Bertrand, R.J.

doi:10.1016/j.ijrobp.2003.10.044

Cited by 514 publications

(314 citation statements)

References 27 publications

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“…PET/CT should be used for RT planning in NSCLC because it more accurately images tumor extent than CT alone [73], This is proven by a large surgical literature on the accuracy of FDG-PET in the lymph node staging of NSCLC [10,68,74,75].…”

Section: Tumor Movementmentioning

confidence: 99%

Use of PET and PET/CT for Radiation Therapy Planning: IAEA expert report 2006–2007

MacManus

Nestle

Rosenzweig

et al. 2009

Radiotherapy and Oncology

331

197

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Section: Tumor Movementmentioning

confidence: 99%

Use of PET and PET/CT for Radiation Therapy Planning: IAEA expert report 2006–2007

MacManus

Nestle

Rosenzweig

et al. 2009

Radiotherapy and Oncology

331

197

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“…( 1 ) Since its inception, numerous researchers have evaluated the potential for PET and PET/CT to be employed in the treatment planning process for lung cancer, with a number of studies focusing specifically on the impact of PET on target volume definition. ( 2 – 5 ) Understanding the efficacy of PET in this context is hindered by the lack of a suitable ground truth, and the ideal methodology for quantitative use of PET or PET/CT in these processes remains a subject of debate. ( 6 , 7 ) It has been shown, however, that interobserver variability is reduced when PET/CT is used for lung cancer radiotherapy target definition.…”

Section: Introductionmentioning

confidence: 99%

Motion artifacts occurring at the lung/diaphragm interface using 4D CT attenuation correction of 4D PET scans

Killoran

Gerbaudo

Mamede

et al. 2011

J Applied Clin Med Phys

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For PET/CT, fast CT acquisition time can lead to errors in attenuation correction, particularly at the lung/diaphragm interface. Gated 4D PET can reduce motion artifacts, though residual artifacts may persist depending on the CT dataset used for attenuation correction. We performed phantom studies to evaluate 4D PET images of targets near a density interface using three different methods for attenuation correction: a single 3D CT (3D CTAC), an averaged 4D CT (CINE CTAC), and a fully phase matched 4D CT (4D CTAC). A phantom was designed with two density regions corresponding to diaphragm and lung. An 8 mL sphere phantom loaded with 18F‐FDG was used to represent a lung tumor and background FDG included at an 8:1 ratio. Motion patterns of sinfalse(normalxfalse) and sin4false(normalxfalse) were used for dynamic studies. Image data was acquired using a GE Discovery DVCT‐PET/CT scanner. Attenuation correction methods were compared based on normalized recovery coefficient (NRC), as well as a novel quantity “fixed activity volume” (FAV) introduced in our report. Image metrics were compared to those determined from a 3D PET scan with no motion present (3D STATIC). Values of FAV and NRC showed significant variation over the motion cycle when corrected by 3D CTAC images. 4D CTAC‐ and CINE CTAC–corrected PET images reduced these motion artifacts. The amount of artifact reduction is greater when the target is surrounded by lower density material and when motion was based on sin4false(normalxfalse). 4D CTAC reduced artifacts more than CINE CTAC for most scenarios. For a target surrounded by water equivalent material, there was no advantage to 4D CTAC over CINE CTAC when using the sinfalse(normalxfalse) motion pattern. Attenuation correction using both 4D CTAC or CINE CTAC can reduce motion artifacts in regions that include a tissue interface such as the lung/diaphragm border. 4D CTAC is more effective than CINE CTAC at reducing artifacts in some, but not all, scenarios.PACS numbers: 87.57.qp, 87.57.cp

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“…In addition, its CT data may be used for radiation therapy planning if properly acquired 78. This modality can be successfully applied to patients with limited-disease small cell lung cancer for whom the treatment is concurrent chemoradiotherapy, with a reported 24% change in the treatment field 79…”

Section: Methodsmentioning

confidence: 99%

¹⁸F-FDG PET/CT Imaging In Oncology

Almuhaideb

Παπαθανασίου

Bomanji

2011

Annals of Saudi Medicine

258

121

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Accurate diagnosis and staging are essential for the optimal management of cancer patients. Positron emission tomography with 2-deoxy-2-[fluorine-18]fluoro- D-glucose integrated with computed tomography (18F-FDG PET/CT) has emerged as a powerful imaging tool for the detection of various cancers. The combined acquisition of PET and CT has synergistic advantages over PET or CT alone and minimizes their individual limitations. It is a valuable tool for staging and restaging of some tumors and has an important role in the detection of recurrence in asymptomatic patients with rising tumor marker levels and patients with negative or equivocal findings on conventional imaging techniques. It also allows for monitoring response to therapy and permitting timely modification of therapeutic regimens. In about 27% of the patients, the course of managment is changed. This review provides guidance for oncologists/ radiotherapists and clinical and surgical specialists on the use of 18F-FDG PET/CT in oncology.

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Impact of FDG-PET on radiation therapy volume delineation in non–small-cell lung cancer

Cited by 514 publications

References 27 publications

Use of PET and PET/CT for Radiation Therapy Planning: IAEA expert report 2006–2007

Use of PET and PET/CT for Radiation Therapy Planning: IAEA expert report 2006–2007

Motion artifacts occurring at the lung/diaphragm interface using 4D CT attenuation correction of 4D PET scans

¹⁸F-FDG PET/CT Imaging In Oncology

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Impact of FDG-PET on radiation therapy volume delineation in non–small-cell lung cancer

Cited by 514 publications

References 27 publications

Use of PET and PET/CT for Radiation Therapy Planning: IAEA expert report 2006–2007

Use of PET and PET/CT for Radiation Therapy Planning: IAEA expert report 2006–2007

Motion artifacts occurring at the lung/diaphragm interface using 4D CT attenuation correction of 4D PET scans

18F-FDG PET/CT Imaging In Oncology

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¹⁸F-FDG PET/CT Imaging In Oncology