Impact of FDG PET in optimizing patient selection for cytoreductive surgery in recurrent ovarian cancer

Abstract

Purpose. To investigate the impact of PET and PET-CT scanning on decision-making in the management plans and to identify the optimal setting for selecting candidate for surgery in suspicious recurrent ovarian cancer. Results. After PET scanning, the management plan was changed on 52 of 89 occasions (58.4%). The total number of cytoreductive surgeries selected as a treatment choice increased from 12 to 35. Miliary disseminated disease, which was not detected by PET scan, was found in 22.2% of surgeries. Miliary disseminated disease was detected in 6 of the 12 recurrent cases whose treatment-free interval (TFI) <12 months, whereas none of those with a TFI ≥12 months had such disease (p=0.0031). MethodsConclusions. PET or PET-CT is useful for selecting cytoreductive surgery candidates among patients with recurrent ovarian cancer. To avoid surgical attempts at miliary dissemination, patients with TFI ≥12 months are the best cytoreducive surgery candidates.

Quantitative metabolic parameters measured on F-18 FDG PET/CT predict survival after relapse in patients with relapsed epithelial ovarian cancer

“…However, pretreatment quantitative metabolic parameters are not entirely reflective of the true tumor burden at the time of relapse. In another prospective study to use FDG PET/CT in optimizing patient selection for SCS in relapsed EOC, SCS was proactively considered only in patients whose FDG uptake patterns are localized and achieved a high rate of complete resection [9]. However, there are no published data on the clinical utility of quantitative metabolic parameters measured on FDG PET/CT at the time of relapse in patients with relapsed EOC.…”

Evaluation of 99mTc-HYNIC-TMTP1 as a tumor-homing imaging agent targeting metastasis with SPECT

“…PET/CT hybrid imaging may increase detectable rate of ovarian cancer, but increased 18 FFDG uptake is associated with malignancy as well as physiological or inflammatory hypermetabolic activity. So it is necessary to find a useful diagnostic tool for detecting ovarian cancer [5][6][7].…”

Good survival in a patient with recurrent transitional cell carcinoma of the ovary: A case report of PET-CT for detection and follow-up

“…In comparison to serum CA-125 assays and conventional imaging (ultrasound/CT/ magnetic resonance imaging), PET-CT has been proven to be more efficient in detecting ovarian cancer recurrence (14). PET-CT is useful for the selection of patients for cytoreductive surgery from those with recurrent ovarian cancer (15). In the present case, TCC with rectal metastases was detected by PET-CT and proven pathologically.…”