Impact of Fasting on Complete Blood Count Assayed in Capillary Blood Samples

Kościelniak, Barbara; Charchut, Aleksandra; Wójcik, Magdalena; Sztefko, Krystyna; Tomasik, Przemysław

doi:10.1093/labmed/lmx044

Cited by 17 publications

(9 citation statements)

References 11 publications

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“…This finding is in line with the reports of Akrami et al [42], Plumelle et al [43] and Turan et al [44] who observed no statistically significant difference between fasting and postprandial levels of these haematological parameters. However, the findings of this study disagrees with the report of Nematy et al [45] who observed higher RBC count following Ramadan fasting and Naderi et al [46], and Koscielnak et al [47] who posited that fasting decreased RBC counts, Hb and HCT.…”

Section: Discussioncontrasting

confidence: 99%

Assessment of Hematological and Serum Electrolytes Effects of Intermittent Fasting on Mice

Ikwuka

Anyaehie

Iyare

et al. 2021

JPRI

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Introduction: There is growing interest on trying to explore the importance of fasting to health as it has been practiced as religious exercises for centuries. This study assessed the haematological and serum electrolytes effects of intermittent fasting (IF) on mice. Methods: Fifty (50) male mice were randomly assigned into five (5) groups A, B, C, D and E (n=10). Group A (control) was fed normal chow ad libitum, experimental groups B,C,D and E were fasted seven weeks intermittently for 12, 18, 24 and 48 hours respectively. Blood samples were collected and analysed for haematological and electrolyte indices. Data obtained were analyzed using IBM SPSS Statistics 25. Results: Our findings revealed no significant differences in the RBC, HGB, HCT, MCV, MCH and MCHC between the different fasting groups and the control. There was increase significantly in group C for Red density width-coefficient of variance (RDW-CV) and group C and E for Red density width-standard deviation (RDW-SD). Platelet count decreased, plateletcrit increased significantly in group C. There were no significant differences in the mean platelet volume (MPV), platelet distribution width (PDW), platelet-large cell count (P-LCC) and Platelet-large cell ratio (P-LCR). Sodium ion decreased significantly in group C and chloride ion decreased significantly in group B, C and E. There were no significant differences in serum potassium ion and bicarbonate ion. Conclusion: 12, 24 and 48 hours IF are safe and do not negatively influence hematological indices and electrolyte levels but 18 hours IF could have a slight negative effect on platelet count, plateletcrit and sodium ion levels.

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Section: Discussioncontrasting

confidence: 99%

Assessment of Hematological and Serum Electrolytes Effects of Intermittent Fasting on Mice

Ikwuka

Anyaehie

Iyare

et al. 2021

JPRI

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“…The observed differences in leukocytes between schizophrenia patients and healthy controls in the included articles were of small magnitude, comparable to the difference seen throughout a day ( 42 ). Also the fasting status is important when comparing blood cell counts, as neutrophil count has been shown to increase after food intake while lymphocyte count decrease ( 32 ).…”

Section: Discussionmentioning

confidence: 99%

Is Elevated Neutrophil Count and Neutrophil-to-Lymphocyte Ratio a Cause or Consequence of Schizophrenia?—A Scoping Review

2021

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Background: Several studies have found an association between elevated neutrophil count or neutrophil-to-lymphocyte ratio (NLR) in peripheral blood from patients with schizophrenia. The etiology behind this effect is unknown, and it is unclear if changes in neutrophil count and NLR may be induced by antipsychotics or if these parameters relate to the diagnosis and symptoms of schizophrenia. The purpose of this scoping review was to map research that explores this association, and to identify gaps in the current knowledge base.Method: The work was conducted in accordance with established methodological standards for scoping reviews. Studies on neutrophil count and NLR in schizophrenia were identified through search in relevant databases, and a parallel screening procedure was performed to ensure validity and reproducibility of the search. Articles that included different comparison groups, with differences in medication status (drug-naïve or drug-free vs. medicated), current disease state (relapse vs. remission), or treatment response, were included, as well as studies evaluating the association between symptomatology and neutrophil count or NLR.Results: The available literature was limited with substantial differences in aims, methods, and outcomes. In total, 13 articles were included for the synthesis of this review. Some interesting trends were identified: Neutrophil count and NLR seem to be elevated in schizophrenia patients regardless of current or past use of antipsychotic therapy. Neutrophil count and NLR correlated significantly with positive symptoms of schizophrenia. Still, these findings should be interpreted with caution due to considerable methodological differences and weaknesses in the literature, particularly concerning the blood sampling procedure.Conclusion: By including longitudinal studies and by comparing patient groups based on medication status, disease state and response, our study provides a basis for dissecting the associations between increased neutrophil count or NLR and a diagnosis of schizophrenia. Further research should investigate and quantify the apparent strong correlation between neutrophil count or NLR and positive symptoms in schizophrenia, to evaluate its clinical potential to guide diagnostics, treatment, or as a predictor of outcome. This review also exposes important methodological weaknesses in the literature on neutrophil count and NLR measurements. Standardization of blood sampling and processing is crucial to reduce bias, and factors that are known to influence leukocyte levels need to be accounted for.

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“…Following a screening period of up to 5 weeks, subjects were randomized in a 1:1 ratio to one of two treatment sequences [Sandoz proposed biosimilar pegfilgrastim followed by reference pegfilgrastim (EU‐authorized) or reference pegfilgrastim (EU‐authorized) followed by Sandoz proposed biosimilar pegfilgrastim]. Pegfilgrastim (Sandoz proposed biosimilar or reference) was administered as a single 6 mg subcutaneous (SC) injection on Day 1 of each period, following a ≥10‐h fast (to avoid the impact of food consumption on the neutrophil count ), into the SC tissue of the lower abdomen. A follow‐up visit was carried out 28 days after pegfilgrastim administration in each period.…”

Section: Methodsmentioning

confidence: 99%

Proposed biosimilar pegfilgrastim shows similarity in pharmacokinetics and pharmacodynamics to reference pegfilgrastim in healthy subjects

Nakov

Gattu

Wang³

et al. 2018

Brit J Clinical Pharma

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Impact of Fasting on Complete Blood Count Assayed in Capillary Blood Samples

Abstract: Food consumption impacts CBC results. To ensure the consistency, quality, and repeatability of CBC analysis, blood should be drawn from fasting patients.

Cited by 17 publications

References 11 publications

Assessment of Hematological and Serum Electrolytes Effects of Intermittent Fasting on Mice

Assessment of Hematological and Serum Electrolytes Effects of Intermittent Fasting on Mice

Is Elevated Neutrophil Count and Neutrophil-to-Lymphocyte Ratio a Cause or Consequence of Schizophrenia?—A Scoping Review

Proposed biosimilar pegfilgrastim shows similarity in pharmacokinetics and pharmacodynamics to reference pegfilgrastim in healthy subjects

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