Impact of family history of gastric cancer on colorectal neoplasias in young Japanese

Hata, Keisuke; Shinozaki, Masaru; Toyoshima, Osamu; Toyoshima, Akira; Matsumoto, Sumio; Saisho, Toshimitsu; Tsurita, Giichiro

doi:10.1111/j.1463-1318.2012.03108.x

Cited by 9 publications

(11 citation statements)

References 21 publications

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“…However, because the prevalence of CRC in this study was extremely low (0.1%), no relationship between GC FH and CRC was seen. Similarly, though a Japanese study that included 300 young adults aged <50 years reported that a FH of GC was an independent risk factor for CRN 15 . However, this did not assess the association between GC FH and CRC risk because the number of patients with CRC was only 4 (1.3%).…”

Section: Discussionmentioning

confidence: 99%

“…To date, only two studies revealed that a FH of GC was a risk factor for colorectal neoplasia (CRN) 14,15 . However, the proportion of CRC among CRN in these two reports was extremely low, and both showed that a FH of GC was associated with an increased risk of colorectal adenoma, a precursor of CRC 14,15 . Whether a FH of GC is related to the risk of CRC and whether an FH of CRC is related to the risk of GC or gastric adenoma, a precancerous lesion of GC, remains ill defined.…”

Section: Introductionmentioning

confidence: 99%

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Mutual association between family history of gastric and colorectal cancer and risk of gastric and colorectal cancer

Jung

Tran

Park

et al. 2023

J of Gastro and Hepatol

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Background and AimWe evaluated the associations between gastric cancer (GC) family history (FH) and colorectal cancer (CRC) risk and between CRC FH and GC/gastric adenoma risk.MethodsWe used data of participants who underwent national cancer screening between 2013 and 2014. Participants with GC or CRC FH in first‐degree relatives (n = 1 172 750) and those without cancer FH (n = 3 518 250) were matched 1:3 by age and gender.ResultsOf the 1 172 750 participants with a FH, 871 104, 264 040, and 37 606 had FHs of only GC, only CRC, and both GC and CRC, respectively. The median follow‐up time was 4.8 years. GC and CRC FHs were associated with increased GC and CRC risks, respectively. GC FH was associated with CRC risk (adjusted hazard ratio 1.05; 95% confidence interval [CI] 1.01–1.10), whereas CRC FH was not associated with the risk of GC or gastric adenoma. However, gastric adenoma risk increased 1.62‐fold (95% CI 1.40–1.87) in participants with FHs of both GC and CRC, demonstrating a significant difference with the 1.39‐fold (95% CI 1.34–1.44) increase in participants with only GC FH. Furthermore, GC risk increased by 5.32 times (95% CI 1.74–16.24) in participants with FHs of both GC and CRC in both parents and siblings.ConclusionsGC FH was significantly associated with a 5% increase in CRC risk. Although CRC FH did not increase GC risk, FH of both GC and CRC further increased the risk of gastric adenoma. FHs of GC and CRC may affect each other's neoplastic lesion risk.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mutual association between family history of gastric and colorectal cancer and risk of gastric and colorectal cancer

Jung

Tran

Park

et al. 2023

J of Gastro and Hepatol

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“…In the present study, we also investigated upper gastrointestinal disorders as the clinical covariables for presence of early colon cancer. It has been well known that patients with gastric cancer frequently show synchronous or metachronous colon cancers, 47–49 and colon cancer and CD have been also reported to be the predictors of the presence of Barrett’s esophagus and reflux esophagitis 30 . On the other hand, Helicobacter pylori infection has showed an inverse correlation with the presence of CD 30 .…”

Section: Discussionmentioning

confidence: 99%

Relationship between colonic diverticulosis and colon neoplasms in Japanese patients

Nakahara

Amano

Murakami

et al. 2020

Digestive Endoscopy

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Background and Aim Colonic diverticulosis (CD) has been reported to be associated with presence of colon neoplasms (CNs) in Western patients, since most of the associated risk factors are common between them. However, such correlation has not been fully investigated in Asian patients. In this study, the association of CNs with CD was evaluated in a multicenter investigation. Methods We enrolled 5633 patients who underwent both colonoscopy and esophagogastroduodenoscopy due to annual follow‐up, screening for positive occult blood testing and abdominal symptoms between January 2016 and December 2017 at three institutions. The relationship between the presence of CNs and CD was investigated, and predictors for presence of CNs were determined by multivariate logistic analysis. Results The enrolled patients consisted of 1799 (31.9%) with CD (average age 70.0 years, male 64.0%) and 3834 without CD (66.0 years, male 52.9%), with the prevalence of CNs in those groups 46.6% and 44.2%, respectively (P = 0.090). Predictors for early colon cancer were shown to be age (OR 1.02, 95% CI 1.01–1.04, P = 0.010), laxatives use (OR 1.76, 95% CI 1.17–2.64, P = 0.007), gastric neoplasms (OR 2.16, 95% CI 1.23–3.81, P = 0.008), and CD (OR 1.64, 95% CI 1.16–2.31, P = 0.005). Early colon cancer in the distal colon was most frequently detected in patients with right‐sided CD (RR 2.50, P = 0.001). Conclusion In Japanese patients, early colon cancer was more frequently found in those with as compared to those without CD. The presence of CD may be an important indicator for an index colonoscopy examination to detect colon cancer. (Clinical‐trial‐registry: UMIN000038985).

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“…Kupelian et al ( 15 ) reported that prostate cancer patients with a family history of prostate carcinoma show worse clinical outcomes. Hata et al ( 16 ) reported that a family history of gastric cancer is a risk factor for colorectal neoplasia. Minami et al ( 17 ) reported that a family history of gastric cancer increases mortality in gastric cancer patients under 60 years old.…”

Section: Discussionmentioning

confidence: 99%

Mixed Carcinoma as an Independent Prognostic Factor in Submucosal Invasive Gastric Carcinoma

et al. 2016

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Mixed carcinoma shows a mixture of glandular and signet ring/poorly cohesive cellular histological components and the prognostic significance of each component is not fully understood. This study aimed to investigate the significance of the poorly cohesive cellular histological component as a risk factor for lymph node metastasis and to examine the diagnostic reliability of endoscopic biopsy. Clinicopathologic characteristics of 202 patients who underwent submucosal invasive gastric carcinoma resection with lymph node dissection in 2005–2012 were reviewed. Mixed carcinoma accounted for 27.2% (56/202) of cases. The overall prevalence of lymph node metastasis was 17.3% (35/202). Lymphatic invasion (P < 0.001), family history of carcinoma (P = 0.025), tumor size (P = 0.004), Lauren classification (P = 0.042), and presence of any poorly cohesive cellular histological component (P = 0.021) positively correlated with the lymph node metastasis rate on univariate analysis. Multivariate analyses revealed lymphatic invasion, family history of any carcinoma, and the presence of any poorly cohesive cellular histological component to be significant and independent factors related to lymph node metastasis. Review of preoperative biopsy slides showed that preoperative biopsy demonstrated a sensitivity of 63.6% and a specificity of 100% in detecting the presence of the poorly cohesive cellular histological component, compared with gastrectomy specimens. The presence of any poorly cohesive cellular histological component was an independent risk factor associated with lymph node metastasis in submucosal invasive gastric carcinoma. Endoscopic biopsy had limited value in predicting the presence and proportion of the poorly cohesive cellular histologic component due to the heterogeneity of mixed carcinoma.

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Impact of family history of gastric cancer on colorectal neoplasias in young Japanese

Abstract: In the young population under 50 years of age, a family history of gastric cancer is an independent risk factor for the development of colorectal neoplasia.

Cited by 9 publications

References 21 publications

Mutual association between family history of gastric and colorectal cancer and risk of gastric and colorectal cancer

Mutual association between family history of gastric and colorectal cancer and risk of gastric and colorectal cancer

Relationship between colonic diverticulosis and colon neoplasms in Japanese patients

Mixed Carcinoma as an Independent Prognostic Factor in Submucosal Invasive Gastric Carcinoma

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