Impact of Family History of Substance Abuse on Admission Opioid Dose, Depressive Symptoms, and Pain Catastrophizing in Patients with Chronic Pain

Pestka, Elizabeth L.; Craner, Julia R.; Evans, Michele M.; Nash, Virginia; Kimondo, Njoki; Pestka, Deborah L.; Loukianova, Larissa L.; Sperry, Jeannie A.

doi:10.1016/j.pmn.2017.09.007

Cited by 9 publications

(12 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our findings are consistent with prior work 16,17,28 that found that a family history of substance use is a potent risk factor for opioid misuse in relatives and that permissive family norms and to substance use among parents and siblings are associated with increased risk of substance use disorders in adolescents. The association of long-term opioid use in family members with persistent opioid use is likely mediated through several pathways.…”

Section: Discussionsupporting

confidence: 92%

“…It is possible that long-term opioid use in family members may indicate the presence of shared genetic polymorphisms associated with chronic pain, opioid metabolism phenotypes, or neurochemical signaling pathways associated with opioid dependence. [12][13][14][15] In addition, families may share common environmental exposures 16,17 or attitudes toward pain management and opioid use that increase the risk of persistent opioid use when adolescents and young adults are exposed to opioids. 18 It is also possible that an opioid prescription filled by an adolescent or young adult may have been diverted for use by another family member.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Association Between Long-term Opioid Use in Family Members and Persistent Opioid Use After Surgery Among Adolescents and Young Adults

et al. 2019

View full text Add to dashboard Cite

Prior studies have found a substantial risk of persistent opioid use among adolescents and young adults undergoing surgical and dental procedures. It is unknown whether family-level factors, such as long-term opioid use in family members, is associated with persistent opioid use. OBJECTIVE To determine whether long-term opioid use in family members is associated with persistent opioid use among opioid-naive adolescents and young adults undergoing surgical and dental procedures. DESIGN, SETTING, AND PARTICIPANTS This retrospective cohort study used data from a commercial insurance claims database for January 1, 2010, to June 30, 2016, to study 346 251 opioid-naive patients aged 13 to 21 years who underwent 1 of 11 surgical and dental procedures and who were dependents on a family insurance plan. EXPOSURES Long-term opioid use in family members, defined as having 1 or more family members who (1) filled opioid prescriptions totaling a 120 days' supply or more during the 12 months before the procedure date or (2) filled 3 or more opioid prescriptions in the 90 days before the procedure date. MAIN OUTCOMES AND MEASURES The main outcome measure was persistent opioid use, defined as 1 or more postoperative prescription opioid fills between 91 and 180 days among patients with an initial opioid prescription fill. Generalized estimating equations with robust SEs clustered at the family level were used to model persistent opioid use as a function of long-term opioid use among family members, controlling for procedure, total morphine milligram equivalents of the initial fill, and patient and family characteristics. RESULTS A total of 346 251 patients (mean [SD] age, 17.0 [2.3] years; 175 541 [50.7%] female) were studied. Among these patients, 257 085 (74.3%) had an initial opioid fill. Among patients with an initial opioid fill, 11 016 (4.3%) had long-term opioid use in a family member. Persistent opioid use occurred in 453 patients (4.1%) with long-term opioid use in a family member compared with 5940 patients (2.4%) without long-term opioid use in a family member (adjusted odds ratio, 1.54; 95% CI, 1.39-1.71). CONCLUSION AND RELEVANCE The findings suggest that long-term opioid use among family members is associated with persistent opioid use among opioid-naive adolescents and young adults undergoing surgical and dental procedures. Physicians should screen young patients for long-term opioid use in their families and implement heightened efforts to prevent opioid dependence among patients with this important risk factor.

show abstract

Section: Discussionsupporting

confidence: 92%

mentioning

confidence: 99%

Association Between Long-term Opioid Use in Family Members and Persistent Opioid Use After Surgery Among Adolescents and Young Adults

et al. 2019

View full text Add to dashboard Cite

show abstract

“…In addition, why people engage in PC was addressed, with communal‐coping, verbalizing the need for social support, and lacking proper coping‐ skills being the most hypothesized reasons (Junghaenel et al, ). Finally, Social Learning Theory was discussed in relation to how children and parents catastrophize their pain (Pestka et al, ). Social factors are linked to genetic factors because PC may “rewire” the brain from a young age to be more sensitive to pain.…”

Section: Resultsmentioning

confidence: 99%

“…It is hypothesized that one place we learn pain behaviors is from our parents. In a recent retrospective family study conducted by Pestka et al (), individuals self‐ reported higher levels of PC on the Pain Catastrophizing Scale with a family history of PC, compared to individuals who did not have a family history of PC. Additionally, Noel, Rabbitts, Tai, and Palermo () found that, for children and parents having surgery, the greatest impact of PC measured in the post‐operative stage was that of the parent's reaction to their child having had surgery.…”

Section: Contributing Social Factorsmentioning

confidence: 99%

An overview of a biopsychosocial model of epigenetics and pain catastrophizing

Brecht

Gatchel

2019

J Appl Biobehavioral Res

View full text Add to dashboard Cite

In an earlier Special Issue in the Journal of Applied Biobehavioral Research (JABR), Gatchel (Journal of Applied Biobehavioral Research, 2017, 22[1], e12088) addressed the construct of pain catastrophizing (PC). The present article is meant to extend those reviews within a biopsychosocial context, as well as update recent research on PC with a specific concentration on genetic factors. An overview of biological factors as they relate to PC and epigenetics are reviewed first (brain areas associated with pain and how they adapt neurochemically to chronic noxious stimuli, polymorphism of various genes, etc.), proceeded by the discussion of psychological (depression, anxiety, and the genomic link to neuroticism) and social influences (reason people engage in PC, age's impact on neuronal restructuring) as they corroborate the argument of PC's link to genetic factors. Finally, this article concludes by providing future directions for research concerning PC such as examining the efficacy of Pain Neurobiology Education, as well as gene therapy.

show abstract

“…32 Patients with a history of substance abuse should be assessed for addictions pre-and postoperatively as well as receive psychoeducation about reoccurrence. Evidence from more general populations suggests that patient risk factors including a family history of substance use 33 and a personal history of substance use disorders (e.g., alcohol, benzodiazepines, illicit drugs) increases the risk of prescription opioid misuse or abuse. 34 Edlund and colleagues 35 reviewed the medical records of more than 15,000 veterans and found that a personal substance abuse history was the single strongest predictor of therapeutic opioid abuse or addiction.…”

Section: Psychosocial Risk Factors For Opioid Use In the General Popumentioning

confidence: 99%

Opioids and bariatric surgery: A review and suggested recommendations for assessment and risk reduction

Heinberg

Pudalov

Alameddin

et al. 2019

Surgery for Obesity and Related Diseases

View full text Add to dashboard Cite

Prescription opioid use has increased significantly over the past 25 years due to a number of factors including efforts to help patients struggling to cope with pain, overprescribing by providers and marketing by pharmaceutical companies. However, opioids provide euphoria as well as analgesia. 1 This euphoria coupled with iatrogenic physical dependence and addictive qualities has contributed to an epidemic of opioid abuse, addiction and overdose. 2 The increased use of opioids for treating non-cancer chronic pain and the increased use of higher-dose and higher bioavailability formulations has added to what the Centers for Disease Control and the Department of Health and Human Services have referred to as an'epidemic'. 1 Clinicians struggle to weigh the potential benefits of long-term opioids therapy (i.e., use of legitimately obtained prescribed opioids at least five days per week for 90 days) with the risk of misuse or addiction. 3 Recently, the Centers for Disease Control (CDC) has issued prescribing guidelines to address the issue of opioid over-use. 4 Obesity and Chronic Pain Co-Morbidity Patients with severe obesity are more likely to experience chronic pain and related increased functional and psychosocial complications related to chronic pain conditions. 5 Chronic pain also has quality of life implications in patients with severe obesity and has been the subject of a prior review A large-scale survey of over 1 million US residents demonstrated a linear relationship between Body Mass Index (BMI) and chronic pain prevalence. 6 Compared to individuals with normal BMIs, individuals who were overweight reported 20% greater rates of chronic pain, people with Class I obesity reported 68% greater, those with Class II reported 136% greater, and those with clinically severe Class III obesity reported 254% greater rates of chronic pain. 7 Recent research has indicated that although pain ratings and overall medication use is significantly reduced following bariatric surgeries, opioid use not only continues but

show abstract

Impact of Family History of Substance Abuse on Admission Opioid Dose, Depressive Symptoms, and Pain Catastrophizing in Patients with Chronic Pain

Cited by 9 publications

References 36 publications

Association Between Long-term Opioid Use in Family Members and Persistent Opioid Use After Surgery Among Adolescents and Young Adults

Association Between Long-term Opioid Use in Family Members and Persistent Opioid Use After Surgery Among Adolescents and Young Adults

An overview of a biopsychosocial model of epigenetics and pain catastrophizing

Opioids and bariatric surgery: A review and suggested recommendations for assessment and risk reduction

Contact Info

Product

Resources

About