Impact of exogenous nicotine on the morphological, physio-biochemical, and anatomical characteristics in Capsicum annuum

Alkhatib, Rami; Alkhatib, Batool; Abdo, Nour

doi:10.1080/15226514.2021.1962798

Cited by 4 publications

(2 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nicotine, the main active and addictive ingredient in tobacco (chemical formula C10H14N2), is an alkaloid found in the Solanaceae plant and is highly toxic [4].…”

Section: A C C E P T E D a R T I C L E 1 Introductionmentioning

confidence: 99%

See 1 more Smart Citation

SERPINE1 as an Independent Prognostic Marker and Therapeutic Target for Nicotine-Related Oral Carcinoma

Guo

Sun

Chen

et al. 2023

Clin Exp Otorhinolaryngol

View full text Add to dashboard Cite

Background: Nicotine is an ingredient of tobacco, and its exposure increases various cancer risks, including oral cancer. Previous studies have focused on its addictive properties, but its carcinogenic mechanism has rarely been studied. We aimed to explore the key genes in the process of nicotine promoting the occurrence and development of oral cancer through data mining and experimental verification. Methods: This study involved three parts. First, the key genes related to nicotine-related oral cancer were screened out through data mining; second, the expression and clinical significance of the key gene in oral cancer tissues were verified by bioinformatics. Finally, the expression and clinical significance of the key gene in oral cancer were histologically investigated, and the effects of its expression on cell proliferation, invasion, and drug resistance were cytologically assessed.Results: SERPINE1 was identified as the key gene, which was upregulated in nicotine-treated oral cells and may be an independent prognostic factor for oral cancer. SERPINE1 was enriched in various pathways such as TNF and Apelin pathways; and was related to the infiltration of macrophages, CD4+T cells, and CD8+T cells. Overexpression of SERPINE1 was associated with N staging and may be involved in hypoxia, angiogenesis, and metastasis. Knockdown of SERPINE1 in oral cancer cells resulted in weakened cell proliferation and invasion ability and increased sensitivity to Bleomycin and Docetaxel. Conclusion: This study revealed SERPINE1 as the key gene for nicotine-related oral cancer, indicating that SERPINE1 may be a novel prognostic indicator and therapeutic target for oral carcinoma.

show abstract

“…Nicotine, the main active and addictive ingredient in tobacco (chemical formula C10H14N2), is an alkaloid found in the Solanaceae plant and is highly toxic [4].…”

Section: A C C E P T E D a R T I C L E 1 Introductionmentioning

confidence: 99%

“…Nicotine, the main active and addictive ingredient in tobacco (chemical formula C 10 H 14 N 2 ), is an alkaloid found in the Nicotiana tabacum plant and is highly toxic [ 4 ]. Research has focused on its addictive properties, but rarely on its carcinogenic properties [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

SERPINE1 as an Independent Prognostic Marker and Therapeutic Target for Nicotine-Related Oral Carcinoma

Guo

Sun

Chen

et al. 2023

Clin Exp Otorhinolaryngol

View full text Add to dashboard Cite

show abstract

Integrative physiological and metabolic traits reveal the mechanisms of chamomile flowers in response to nicotine stress

Zhou,

Luo,

Pang

et al. 2023

Chem. Biol. Technol. Agric.

View full text Add to dashboard Cite

Background Chamomile (Matricaria recutita L.) is an important economic crop after tobacco (Nicotiana tabacum L.) cultivation. The nicotine released into the soil during tobacco cultivation has an impact on various aspects of chamomile growth, including plant height, flowering period, flower yield, and flower quality. We aimed to examine the effects of physiological and metabolic response of chamomile under different concentrations of nicotine stress. Results The study revealed that chamomile growth was positively influenced by nicotine concentrations of 1.0 μg/g (N-1) and 10.0 μg/g (N-10). However, higher nicotine concentrations of 100.0 μg/g (N-100) and 500.0 μg/g (N-500) were found to induce stress as the highest levels of antioxidant enzyme activities and malondialdehyde (MDA) levels were observed under this treatment. In addition, it was observed that nicotine was transported from the roots to other organs during the entire growth period of chamomile and the nicotine levels reached saturation under N-100 treatment. A total of 1096 metabolites were detected by ultra-high-performance liquid chromatography-coupled tandem mass spectrometry (UHPLC–MS/MS) analysis, and 48 differentially expressed metabolites (DEMs) were identified among the groups via widely targeted metabolomics studies. The response of chamomile flowers to nicotine stress is associated with the presence of flavonoids, phenolic acids, organic acids, and other substances. Metabolic regulation under nicotine stress primarily involves processes, such as aminoacyl-tRNA biosynthesis, ABC (ATP-binding cassette) transporter activity, glyoxylate and dicarboxylate metabolism and pyrimidine metabolism. Conclusions This report presents the first findings on how nicotine affects the metabolism of chamomile. It also provides a comprehensive understanding of how crops can resist nicotine stress from a metabolic perspective. Graphical Abstract

show abstract

Tobacco Cultivation Leads to the Accumulation of Alkaloids in the Soil and Causes Potential Risks

Zhou,

Luo,

et al. 2024

Preprint

View full text Add to dashboard Cite

Impact of exogenous nicotine on the morphological, physio-biochemical, and anatomical characteristics in Capsicum annuum

Cited by 4 publications

References 38 publications

<i>SERPINE1</i> as an Independent Prognostic Marker and Therapeutic Target for Nicotine-Related Oral Carcinoma

<i>SERPINE1</i> as an Independent Prognostic Marker and Therapeutic Target for Nicotine-Related Oral Carcinoma

Integrative physiological and metabolic traits reveal the mechanisms of chamomile flowers in response to nicotine stress

Tobacco Cultivation Leads to the Accumulation of Alkaloids in the Soil and Causes Potential Risks

Contact Info

Product

Resources

About