Impact of exercise on neuroplasticity-related proteins in spinal cord injured humans

Vega, Sandra Rojas; Abel, Thomas; Lindschulten, Ralf; Hollmann, W; Bloch, Wilhelm; Strüder, Heiko K.

doi:10.1016/j.neuroscience.2008.03.037

Cited by 57 publications

(27 citation statements)

References 54 publications

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“…Several neurochemicals, including brain-derived neurotrophic factor (BDNF), insulin-like growth factor-1 (IGF-1), and vascular endothelial growth factor (VEGF), are currently considered key proteins that mediate downstream effects of exercise on the brain and cognition (Cotman et al, 2007). As a single bout of physical exercise may lead to an increase in BDNF level (Ferris et al, 2007;Griffin et al, 2011), these exercise-increased neurotrophins may contribute to a reduction in mood disorders and to the protection and regeneration of various tissues resulting in increased cognitive performance in humans (Hansen et al, 2001;Rojas Vega et al, 2008;Zoladz and Pilc, 2010).…”

Section: Introductionmentioning

confidence: 99%

Acute Sprint Interval Exercise Increases Both Cognitive Functions and Peripheral Neurotrophic Factors in Humans: The Possible Involvement of Lactate

Kujach

Olek²,

Byun

et al. 2020

Front. Neurosci.

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Section: Introductionmentioning

confidence: 99%

Acute Sprint Interval Exercise Increases Both Cognitive Functions and Peripheral Neurotrophic Factors in Humans: The Possible Involvement of Lactate

Kujach

Olek²,

Byun

et al. 2020

Front. Neurosci.

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“…Further, aerobic exercise can modify plasticity [83] via increases in cerebral blood flow [84] and angiogenesis [85]. Rojas Vega et al [86] investigated the effects of aerobic exercise on BDNF and IGF-1 serum concentrations in SCI participants. The SCI participants completed an aerobic exercise session on a hand-bike that included a 10-min warm-up followed by a timed trial over a distance of 42 km.…”

Section: Pairing Nibs With Aerobic Exercisementioning

confidence: 99%

“…The warmup resulted in a 1.5-fold increase in BDNF concentration, although no significant differences were seen between pre-and post-aerobic exercise measures. Additionally, IGF-1 concentrations were increased following both the warm-up and aerobic exercise [86] suggesting that aerobic exercise has the ability to prime the central nervous system for neuroplastic changes. This has been supported by recent evidence that aerobic exercise, such as cycling, is able to prime the brain prior to NIBS in healthy participants [87,88].…”

Section: Pairing Nibs With Aerobic Exercisementioning

confidence: 99%

Non-invasive Brain Stimulation to Characterize and Alter Motor Function after Spinal Cord Injury

Bailey¹,

Fassett²,

Lulic³

et al. 2016

Recovery of Motor Function Following Spinal Cord Injury

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Abstract"dvances in transcranial magnetic stimulation TMS now permit the precise assessment of circuitry in human motor cortices that contribute to movement. Further, TMS approaches are used to promote neural plasticity within cortical and spinal circuitry in an attempt to create short-term changes in motor control. This review is focused on the application of TMS techniques in the study of characterizing and promoting neural plasticity within individuals presenting with chronic spinal cord injury. We review TMS research performed in individuals with SCI and consider new opportunities for the use of TMS approaches to promote neural plasticity for improving motor recovery.

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“…Exercise increases BDNF mRNA and protein in cerebral cortex, cerebellum, and spinal cords of rodents [76,171‐173], sometimes in as little as 30 minutes [174]. In human beings with spinal cord injury, multiple brain regions show activity‐dependent increases in BDNF levels after 10 to 30 minutes of activity [175]. Because exercise has been shown to up‐regulate BDNF, addition of exercise therapy in a stroke patient's daily routine may have a positive impact on plasticity.…”

Section: Genetic Influences On Other Plasticity‐related Processesmentioning

confidence: 99%

Genetic Influences on Neural Plasticity

Pearson-Fuhrhop

Cramer

2010

PM&R

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Neural plasticity refers to the capability of the brain to alter function or structure in response to a range of events and is a crucial component of both functional recovery after injury and skill learning in healthy individuals. A number of factors influence neural plasticity and recovery of function after brain injury. The current review considers the impact of genetic factors. Polymorphisms in the human genes coding for brain-derived neurotrophic factor and apolipoprotein E have been studied in the context of plasticity and stroke recovery and are discussed here in detail. Several processes involved in plasticity and stroke recovery, such as depression or pharmacotherapy effects, are modulated by other genetic polymorphisms and are also discussed. Finally, new genetic polymorphisms that have not been studied in the context of stroke are proposed as new directions for study. A better understanding of genetic influences on recovery and response to therapy might allow improved treatment after a number of forms of central nervous system injury.

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Impact of exercise on neuroplasticity-related proteins in spinal cord injured humans

Cited by 57 publications

References 54 publications

Acute Sprint Interval Exercise Increases Both Cognitive Functions and Peripheral Neurotrophic Factors in Humans: The Possible Involvement of Lactate

Acute Sprint Interval Exercise Increases Both Cognitive Functions and Peripheral Neurotrophic Factors in Humans: The Possible Involvement of Lactate

Non-invasive Brain Stimulation to Characterize and Alter Motor Function after Spinal Cord Injury

Genetic Influences on Neural Plasticity

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