Impact of Ethanol Extract of Lasianthera Africana Leaf on Kidney Function Biomarkers of Testosterone Propionate-Induced Prostatitis in Male Wistar Rats

Abstract

The impact of the ethanol extract of the plant on kidney function markers of Testosterone propionate induced prostatitis were studied and the PSA level of the male wistar rats used was also studied. Thirty male wistar rats were grouped into six groups (group1-6) of five rats each. Normal water and the rat feeds were given to rats in group 1 ad libitum and they were not treated. Prostatitis was induced to the rats in groups 2 to 6 for four days after which treatment commenced for 28 days. The reference drug (Contiflo XL (400μg)) was administered to Group 3, the rats in groups 4 and 5 received 100mg and 200mg of the plant extract respectively while group 6 were administered a combined dose of 100mg of plant extract and contiflo XL. Qualitative phytochemical analysis of the plant leaf revealed the presence of polyphenols (+++), alkaloids (+++), saponins (++), tannins (++) and flavonoids (+). The PSA Level that was observed to be increased after induction of prostatitis in group2 was significantly decreased when 200mg of the leaf ethanol extract of the plant was administered to group 4. The other groups (3, 5 and 6) were also decreased when compared to group 2. For all the kidney function biomarkers analyzed, a significant increase was observed in group2 when compared with group 1. After the period of treatment, urea, creatinine and the electrolytes (Na+ , Cl- , K+ and HCO3 - ) were observed to be significantly decreased when 100mg of the extract was administered showing the much potency it has in the disease management except for bicarbonate where 200mg of the extract had more potency. This study has revealed that the plant leaf ethanol extract is suitable for the management of prostatitis and has ameliorative effect on the kidney function biomarkers of male wistar rats induced with prostatitis.