Impact of endometriosis on quality of life and work productivity: a multicenter study across ten countries

Nnoaham, Kelechi E.; Hummelshøj, Lone; Webster, Premila; D’Hooghe, Thomas; Nardone, Fiorenzo De Cicco; Nardone, Carlo de Cicco; Jenkinson, Crispin; Kennedy, Stephen; Zondervan, Krina T.

doi:10.1016/j.fertnstert.2011.05.090

Cited by 1,174 publications

(1,122 citation statements)

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“…A wide spectrum of symptom severity exists, and the stage of endometriosis at laparoscopy is poorly correlated with the extent and severity of pain, often resulting in misdiagnosis or delay in diagnosis [3]. This is the case with DIE, as symptoms are not specific [2,3]. Bimanual pelvicgynaecologic examination may suggest the presence of DIE by the identification of tender nodules and fibrosis in the cul de sac, but it has poor accuracy in determining the extent of disease [3,36].…”

Section: Deep Infiltrating Endometriosis Diagnostic Imaging and Implimentioning

confidence: 99%

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Imaging for the evaluation of endometriosis and adenomyosis

Exacoustòs

Manganaro

Zupi

2014

Best Practice & Research Clinical Obstetrics & Gynaecol

207

143

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Endometriosis affects between 5 and 45% of women in reproductive age, is associated with significant morbidity, and constitutes a major public health concern. The correct diagnosis is fundamental in defining the best treatment strategy for endometriosis. Therefore, non-invasive methods are required to obtain accurate diagnoses of the location and extent of endometriotic lesions. Transvaginal sonography and magnetic resonance imaging are used most frequently to identify and characterise lesions in endometriosis. Subjective impression by an experienced sonologist for identifying endometriomas by ultrasound showed a high accuracy. Adhesions can be evaluated by real-time dynamic transvaginal sonography, using the sliding sign technique, to determine whether the uterus and ovaries glide freely over the posterior and anterior organs and tissues. Diagnosis is difficult when ovarian endometriomas are absent and endometriosis causes adhesions and deep infiltrating nodules in the pelvic organs. Magnetic resonance imaging seems to be useful in diagnosing all locations of endometriosis, and its diagnostic accuracy is similar to those obtained using ultrasound. Transvaginal ultrasound has been proposed as first line-line imaging technique because it is well accepted and widely available. The main limitation of ultrasound concerns lesions located above the rectosigmoid junction owing to the limited field-of-view of the transvaginal approach and low accuracy in detecting upper bowel lesions by transabdominal ultrasound. A detailed non-invasive diagnosis of the extension in the pelvis of endometriosis can facilitate the choice of a safe and adequate surgical or medical treatment

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Section: Deep Infiltrating Endometriosis Diagnostic Imaging and Implimentioning

confidence: 99%

“…Endometriosis is estimated to affect between 5% and 45% of women of reproductive age, is associated with significant morbidity, and constitutes a major public health concern [1,2]. Symptoms of women with pelvic endometriosis are chronic pelvic pain, dysmenorrhoea, dyspareunia, dyschezia, urinary symptoms, and infertility.…”

Section: Introductionmentioning

confidence: 99%

Imaging for the evaluation of endometriosis and adenomyosis

Exacoustòs

Manganaro

Zupi

2014

Best Practice & Research Clinical Obstetrics & Gynaecol

207

143

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“…Deep infiltrating endometriosis (DIE) is defined as an endometriotic lesion penetrating to a depth of at least 5 mm (2) and it affects between 4% and 37% of patients with pelvic endometriosis, often causing pelvic pain, dysmenorrhea, dyspareunia, dyschezia, urinary symptoms, and infertility (3). Symptoms caused by DIE are not specific, often resulting in misdiagnosis or delayed diagnosis (4,5). The pelvic examination may suggest a diagnosis of DIE by the presence of tender nodules and fibrosis in the culde-sac, but it is not very accurate in determining the extent of the disease (6).…”

mentioning

confidence: 99%

Ultrasound mapping system for the surgical management of deep infiltrating endometriosis

Exacoustòs

Malzoni²,

Giovanni³

et al. 2014

Fertility and Sterility

134

143

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Objective: To assess the accuracy of transvaginal sonography (TVS) in defining size and location of deep infiltrating endometriosis (DIE) with laparoscopic/histologic confirmation. Design: Prospective observational study. Setting: University hospital. Patient(s): One hundred four women with suspected DIE on the basis of TVS. Intervention(s): Patients with DIE underwent TVS evaluation before laparoscopic surgery. An accurate mapping of the extent of the disease was recorded during TVS and at laparoscopy. This new mapping system was developed to assess the extent of endometriosis by measuring the size and depth of the lesions at the various pelvic locations. Main Outcome Measure(s): Surgical and histologic confirmation of the ultrasonographic data to evaluate the presence and location of DIE and creation of a new mapping methodology for detecting DIE by TVS. Result(s): Depending on the different location of the lesions, the accuracy of TVS ranged from 76%-97%. The lowest sensitivity (59%) and accuracy (76%) were obtained for TVS in the diagnosis of vaginal endometriosis, whereas the greatest accuracy (97%) was shown in detecting bladder lesions and Douglas obliteration. Conclusion(s):This new ultrasound mapping system is accurate for detecting the extent of DIE and may be useful for preoperative planning and intraoperative management of symptomatic patients with DIE. (Fertil Steril Ò

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“…A WPAI kérdőív eredményeit összevetve más szerzők adataival, megállapítható, hogy a betegek teljesítménye (mind a munkában, mind az általános napi tevékeny-ségben) változó mértékben csökkent, de összességében jelentős [34,35]. Simoens és mtsai átlag 755 €/év munkateljesítmény-csökkenést mutattak ki, ami kevesebb a hazai átlagnál, de ez nem elhanyagolható kieső összeg a betegek számára [36].…”

Section: Eredeti Közleményunclassified

The impact of endometriosis on quality of life in Hungary

et al. 2013

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Bevezetés: Az endometriosis az egyik leggyakoribb nőgyógyászati betegség, több mint 70 millió felnőtt és serdülő nőt érint világszerte. Célkitűzés: A szerzők az endometriosis diagnosztikus késedelmi idejének meghatározását, a sebészi, illetve kombinált műtéti kezelés hatékonyságának vizsgálatát, valamint a betegek életminőségének felmérését tűzték ki célul. Módszer: A beválogatási kritériumoknak megfelelő 240, endometriosisban szenvedő nőből 84 vett részt a retrospektív és prospektív kérdőíves felmérésben. Eredmények: A tünetek kezdetétől a diagnózisig átlagosan 3,9 év telt el. A tünetek fellépésekor a betegek 89%-a, a kezelést követő prospektíven vizsgált hónapokban 28%-a panaszkodott fájdalomról (p = 0,025). A sebészi kezelés és a műtéti terápiával kombinált konzervatív kezelés hatékonysága között nem találtak szignifi káns különbséget (p = 0,85). A munkahelyi teljesítmény csökkenéséről a betegek 47%-a, míg a személyes kapcsolatok kedvezőtlen alakulásáról a vizsgálatban részt vevők 40%-a számolt be. Az életminőségre standardizált életévveszteség egy év alatt 0,147 volt. Következtetések: Jelen felmérés az első hazai prospektív, az endometriosis életminőségre gyakorolt hatását vizsgáló tanulmány. A betegségre hosszú diagnosztikus késés jellemző. Az endometriosis jelentősen rontja az életminőséget, de adekvát kezeléssel a panaszok csökkenthetők.

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Impact of endometriosis on quality of life and work productivity: a multicenter study across ten countries

Cited by 1,174 publications

References 38 publications

Imaging for the evaluation of endometriosis and adenomyosis

Imaging for the evaluation of endometriosis and adenomyosis

Ultrasound mapping system for the surgical management of deep infiltrating endometriosis

The impact of endometriosis on quality of life in Hungary

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