Impact of endogenous and exogenous progesterone exposure on stress biomarkers: a systematic review

Stadler, A; Weidlinger, Susanna; Stute, Petra

doi:10.1080/13697137.2019.1622085

Cited by 12 publications

(8 citation statements)

References 81 publications

(298 reference statements)

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“…To date, only seven studies (of roughly 49 currently available studies on cardiac vagal activity across the menstrual cycle as suggested by our meta-analysis [28] and a recent review [30]) have reported associations between ovarian hormone levels and cardiac vagal activity, with mixed results [27,[31][32][33][34][35][36]. However, four major methodological and statistical limitations in these studies prevent clear conclusions.…”

Section: Introductionmentioning

confidence: 77%

Menstrual Cycle Changes in Vagally-Mediated Heart Rate Variability Are Associated with Progesterone: Evidence from Two Within-Person Studies

Schmalenberger

Eisenlohr‐Moul

Jarczok

et al. 2020

JCM

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A recent meta-analysis revealed that cardiac vagal activity (mostly indicated by vagally-mediated heart rate variability; HRV) decreases significantly from the follicular to luteal menstrual cycle phase in naturally-cycling participants. However, the question remains as to whether cyclical changes in estradiol (E2), progesterone (P4), or both are responsible for HRV fluctuations. We present the first studies to use repeated measures of E2, P4, and HRV across the cycle to model both the unique and interactive effects of person-centered E2 and P4 on HRV in multilevel models. In study one, 40 naturally-cycling participants were assessed weekly across four weeks, and were blind to the cycle focus of the study. In study two, 50 naturally-cycling participants were examined in three precisely defined cycle phases via ovulation testing. Both studies revealed that only P4 was correlated with HRV, such that higher-than-usual P4 significantly predicted lower-than-usual HRV within a given participant. In line with this, cycle phase comparisons revealed lower HRV in the mid-luteal phase (characterized by elevated P4) than in other phases. No significant main or interactive effects of E2 on HRV were found. Future female health studies should investigate individual differences in these effects and potential consequences of cyclical HRV changes on daily functioning.

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Section: Introductionmentioning

confidence: 77%

Menstrual Cycle Changes in Vagally-Mediated Heart Rate Variability Are Associated with Progesterone: Evidence from Two Within-Person Studies

Schmalenberger

Eisenlohr‐Moul

Jarczok

et al. 2020

JCM

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“…The progestin-only contraceptives in this study used levonorgestrel, which differs from endogenous progesterone and may attenuate the magnitude of the phase-based increase in sympathetic activity caused by endogenous progesterone during the late luteal phase noticed with NM (30). Stadler et al (40) reviewed the effects of endogenous and exogenous progesterone on the ANS and hypothalamic–pituitary–adrenal axis, which are both activated by stressors. They noticed that the hypothalamic–pituitary–adrenal axis activity was not affected by endogenous progesterone exposure across the MC but might be reduced by exogenous progestin.…”

Section: Discussionmentioning

confidence: 99%

Nocturnal Heart Rate Variability in Women Discordant for Hormonal Contraceptive Use

Ahokas

Hanstock

Löfberg

et al. 2023

Medicine &Amp; Science in Sports &Amp; Exercise

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Purpose: The aim of this study was to investigate within-cycle differences in nocturnal heart rate (HR) and heart rate variability (HRV) in naturally menstruating women (NM) and women using combined hormonal contraceptives (CU) or progestin-only hormonal contraceptives (PU). Methods: Physically active participants were recruited into three groups: NM (n = 19), CU (n = 11), and PU (n = 12). Participants' HR and HRV (with Bodyguard 2 HRV monitor) and blood hormones were monitored during one menstrual cycle (MC) (NM group) or for 4 wk (CU and PU groups). Estradiol, progesterone, and luteinizing hormone were analyzed from fasting blood samples collected four times in the NM (M1 = bleeding, M2 = follicular phase, M3 = ovulation, and M4 = luteal phase) and PU groups (M1 = lowest E 2 , M2 = M1 + 7 d, M3 = M1 + 14 d, and M4 = M1 + 21 d) and twice in the CU group (active and inactive pill phases). After every blood sample, nightly HR and HRV were recorded and examined as an average from two nights. Results: Hormonal concentrations differed (P < 0.05) between MC phases in the NM and PU groups, but not (P ≥ 0.116) between the active and the inactive phases in the CU group. In the NM and PU groups, some of the HRV values were higher, whereas in the NM group, HR was lower during M2 compared with M3 (P < 0.049) and M4 (P < 0.035). In the CU group, HRV values (P = 0.014-0.038) were higher, and HR was lower (P = 0.038) in the inactive phase compared with the first week of the active phase. Conclusions: The MC and the hormonal cycle phases influence autonomic nervous system balance, which is reflected in measurements of nocturnal HR and HRV. This should be considered when monitoring recovery in physically active individuals.

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“…Oestrus synchronisation and superovulation protocol may be a source of stress to the animal as administration of such hormones will alter the natural reproductive physiological process in the body of the animal (Stadler et al, 2019). Haematological indices such as erythrocyte count, packed cell volume, haemoglobin concentration and leucocyte counts are reliable markers of stress in animals (Vinodhini and Narayanan 2009).…”

Section: Discussionmentioning

confidence: 99%

Haematological Responses following Oestrus synchronisation and superovulation protocols in West African Dwarf Goats

Adah

2023

MKH

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Experiments were performed to evaluate the haematological (erythrocyte and leucocyte parameters) response of West African Dwarf goats following oestrus synchronisation and superovulation protocol. Twenty-four clinically healthy female goats aged 2.34 ± 0.4 years and average body weight of 13.83 ± 0.7 kg was used for the experiment. The goats were divided into two groups. Group I goats was synchronized using Controlled Internal Drug Release (CIDR) for 18 days with the first day of insertion as day 0. On day 16 following CIDR insertion into the vagina, a single dose of 500 IU equine chorionic gonadotropin (eCG) was administered to each doe intramuscularly while group II served as the control was subjected to the same housing and environmental conditions but was not synchronized. superovulation was induced with porcine follicle stimulating hormone (pFSH) which was injected intramuscularly at a rate of 5mg/kg in reducing doses twice a day at 06.00 h and 18.00 h for 3 days starting from 48hr i.e., 2 days before CIDR removal (day 17). A blood sample of 5 mL was collected by jugular venipuncture of each of the goats before the protocol (Day 0) and at the end of the protocol (Day 18). All erythrocyte parameters evaluated showed a significantly higher value in group II (control) compared to group I post-oestrus synchronisation while total leucocyte count, neutrophil count and neutrophil/lymphocyte ratio values obtained after the protocol were also higher in group I (P < 0.05) compared to group II. It is therefore concluded that oestrus synchronisation and superovulation may elicit stress in West African Dwarf goats and an appropriate antioxidant should be part of the protocol.

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Impact of endogenous and exogenous progesterone exposure on stress biomarkers: a systematic review

Cited by 12 publications

References 81 publications

Menstrual Cycle Changes in Vagally-Mediated Heart Rate Variability Are Associated with Progesterone: Evidence from Two Within-Person Studies

Menstrual Cycle Changes in Vagally-Mediated Heart Rate Variability Are Associated with Progesterone: Evidence from Two Within-Person Studies

Nocturnal Heart Rate Variability in Women Discordant for Hormonal Contraceptive Use

Haematological Responses following Oestrus synchronisation and superovulation protocols in West African Dwarf Goats

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