Impact of Endocrine Disrupting Chemicals (EDCs) on Reproductive Health of Human

Ghosh, Arindam; Tripathy, Adrija; Ghosh, Debidas

doi:10.1007/s12595-021-00412-3

Cited by 37 publications

(22 citation statements)

References 90 publications

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“…[2] Environmental chemicals with endocrine-disrupting capabilities could lead to significantly reduced sperm count and quality in animals and humans. [2][3][4] Atrazine (ATZ), for example, is an agricultural herbicide with endocrine-disrupting effects on the testis and possesses the ability to produce oxidative stress in the gonads. [5][6][7][8] In males, atrazine is a gonadotoxin.…”

Section: Introductionmentioning

confidence: 99%

Atrazine exposure caused oxidative stress in male rats and inhibited brain‐pituitary‐testicular functions

Rotimi,

Ojo,

Adeyemi

2023

J Biochem & Molecular Tox

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Exposure to the herbicide atrazine has been shown to have deleterious effects on human and animal reproduction. To determine whether atrazine influences the brain‐pituitary‐testicular axis directly or indirectly, the present study examined the toxic effects of atrazine on fertility potential by assessing gonadal hormones, testicular function indices, sperm quality, and oxido‐inflammatory markers in rats. Twelve animals were grouped into two groups; control and atrazine. The control group received oral administration of olive oil (2 mL/kg), while the atrazine group received 120 mg/kg of atrazine. Treatments were daily and lasted for 7 days. Upon treatment cessation, rats were necropsied for biochemical and histopathological analyses. The biochemical function indices in the rat brain, testis, and epididymis decreased significantly in the atrazine group. Atrazine exposure led to decreases in gonadal hormonal concentrations, semen quality parameters, and testicular function indices compared with the control. Furthermore, there was a marked increase in oxidative stress and inflammatory markers as well as degeneration of the histo‐architecture in atrazine‐treated rats. Overall, atrazine exposure impaired sperm quality, led to increased inflammation and oxidative stress, and decreased the activity of the brain‐pituitary‐testicular axis via endocrine disruption.

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Section: Introductionmentioning

confidence: 99%

Atrazine exposure caused oxidative stress in male rats and inhibited brain‐pituitary‐testicular functions

Rotimi,

Ojo,

Adeyemi

2023

J Biochem & Molecular Tox

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“…FSH also stimulated Sertoli cells to produce androgenbinding protein (ABP) which binds testosterone to stimulate the development of spermatogonia. Decreases in testosterone and FSH affected testicular structures, such as the diameter of the seminiferous tubules and spermatogenic cells (Ghosh et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Tomato (Lycopersicon esculentum Mill.) juice restored the number of Leydig cells, and the diameter of the seminiferous tubules of mice (Mus musculus) exposed to lead acetate

Septiani¹,

Hamid²,

Sabdoningrum³

et al. 2022

Ovz

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Lead is a harmful pollutant from engine exhaust that causes free radicals and has detrimental effects on the testicular tissue. This study aimed to determine the effects of tomato juice on the number of Leydig cells and the diameter of the seminiferous tubules of mice exposed to lead acetate. Twenty-five male mice were divided into five groups. Mice in the control (C-) group were given placebos. Meanwhile, mice in C+, T1, T2, and T3 groups were exposed to lead acetate at a dose of 100 mg/kg BW/day for 14 days and given tomato juice respectively at 0, 0.16, 0.32, and 0.64 mL/day from day 8 to day 35. On day 36, all mice were sacrificed, and the testes were collected for histological preparation. The result showed that lead exposure in the C+ group decreased (p <0.05) in the number of Leydig cells and the diameter of the seminiferous tubules compared to the mice in group C-. Administration of tomato juice in groups T1, T2, and T3 increased (p <0.05) the number of Leydig cells and the diameter of seminiferous tubule compared to the mice in the C+ and C- groups. However, tomato juice administration to the T3 group decreased the number of Leydig cells and the diameter of the seminiferous tubules (p <0.05) compared to the T2 group. In conclusion, an effective dose of 0.32 mL/day of tomato juice restored Leydig cell number and seminiferous tubules diameter in mice exposed to lead acetate.

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“…Aneuploidy, caused by aberrant segregation of chromosomes, can lead to miscarriage or birth defects, such as trisomy 21 (Down syndrome), trisomy 18 (Edwards syndrome), and trisomy 13 (Patau syndrome) [64]. Exposure to EDC, aging, and lifestyle factors can contribute to aneuploidy of the oocytes [65,66]. Aging has also been associated with decreased expression of key genes involved in the DNA repair of DSBs in human and mouse oocytes [67].…”

Section: Discussionmentioning

confidence: 99%

Hexavalent Chromium Induces Infertility in Rats by Elevating Oxidative Stress, DNA Double-Strand Breaks, Microtubule Disruption, and Aberrant Segregation of Chromosomes in the Metaphase-II Oocytes

Wuri¹,

Burghardt²,

Arosh³

et al. 2023

Preprint

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Environmental and occupational exposure to hexavalent chromium, Cr(VI), causes female reproductive failures and infertility. Cr(VI) is used in more than 50 industries and is a group-A carcinogen, mutagenic and teratogenic, and a male and female reproductive toxicant. Our previous findings indicate that Cr(VI) causes follicular atresia, trophoblast cell apoptosis, and mitochondrial dysfunction in metaphase II (MII) oocytes. However, the integrated molecular mechanism of Cr(VI)-induced oocyte defects are not understood. The current study investigates the mechanism of Cr(VI) in causing meiotic disruption of MII oocytes, leading to infertility in superovulated rats. Postnatal day (PND)-22 rats were treated with potassium dichromate (1 and 5 ppm) in drinking water from PND 22-29 and superovulated. MII oocytes were analyzed by immunofluorescence, and images were captured by confocal microscopy and quantified by Image Pro Plus software. Our data showed that Cr(VI) increased microtubule misalignment, missegregation of chromosomes, a bulged and folded actin cap, oxidative DNA and protein damage, increased DNA double-strand break, and DNA repair protein RAD51. Cr(VI) also induced incomplete cytokinesis and delayed polar body extrusion. Our study indicates that exposure to environmentally relevant doses of Cr(VI) caused severe DNA damage, distorted oocyte cytoskeletal proteins, and caused oxidative DNA and protein damage leading to infertility.

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Impact of Endocrine Disrupting Chemicals (EDCs) on Reproductive Health of Human

Cited by 37 publications

References 90 publications

Atrazine exposure caused oxidative stress in male rats and inhibited brain‐pituitary‐testicular functions

Atrazine exposure caused oxidative stress in male rats and inhibited brain‐pituitary‐testicular functions

Tomato (Lycopersicon esculentum Mill.) juice restored the number of Leydig cells, and the diameter of the seminiferous tubules of mice (Mus musculus) exposed to lead acetate

Hexavalent Chromium Induces Infertility in Rats by Elevating Oxidative Stress, DNA Double-Strand Breaks, Microtubule Disruption, and Aberrant Segregation of Chromosomes in the Metaphase-II Oocytes

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