Impact of emulsifiers for the nanoencapsulation with maltodextrin of cannabis oil by spray drying on the physicochemical properties and bioaccessibility of cannabinoids

Lajoie, Camille; Feutry, Perrine; Gagnon, Diane; Doyen, Alain; Brisson, G. J.

doi:10.1039/d2fo01591a

Cited by 3 publications

(5 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lajoie et al (2022), described the effect of various emulsifiers, specifically whey and soy protein isolate, as well as Tween 80, on the ability to encapsulate cannabis oil with maltodextrin. Their results suggest that the spray drying of nanoencapsulated cannabis oil using tested emulsifiers has a significant impact on its encapsulation effectiveness and bioavailability and highlights the importance of choosing the appropriate emulsifying agents for optimal oral administration [ 92 ].…”

Section: Resultsmentioning

confidence: 99%

Exploring the Potential of Cannabinoid Nanodelivery Systems for CNS Disorders

et al. 2023

View full text Add to dashboard Cite

Cannabinoids have a major therapeutic value in a variety of disorders. The concepts of cannabinoids are difficult to develop, but they can be used and are advantageous for a number of diseases that are not sufficiently managed by existing treatments. Nanoconjugation and encapsulation techniques have been shown to be effective in improving the delivery and the therapeutic effectiveness of drugs that are poorly soluble in water. Because the bioavailability of cannabinoids is low, the challenge is to explore different administration methods to improve their effectiveness. Because cannabinoids cross the blood-brain-barrier (BBB), they modify the negative effects of inflammatory processes on the BBB and may be a key factor in the improvement of BBB function after ischemic disease or other conditions. This review discusses various types of cannabinoid administration, as well as nanotechnologies used to improve the bioavailability of these compounds in CNS diseases.

show abstract

Section: Resultsmentioning

confidence: 99%

Exploring the Potential of Cannabinoid Nanodelivery Systems for CNS Disorders

et al. 2023

View full text Add to dashboard Cite

show abstract

“…While a simple UV-Vis detector was coupled to a UPLC system to determine CBD (5) and Δ 9 -THC ( 14), 129 a DAD was used for the identification of CBC (1), CBD (5), CBDA (6), CBG (8), CBGA (9), CBN (10), Δ 9 -THC ( 14), Δ 9 -THCA (15), THCV (16), and THCVA (17) 48 in cannabis oil samples. Manca et al 130 used an UHPLC-MS for the identification of CBD ( 5), CBDA (6), CBN (10), Δ 9 -THC ( 14), and Δ 9 -THCA (15); in this piece of work, the noticeable things were the length of the column, which was just 30 mm, and the use of isopropanol in the mobile phase, in addition to water and ACN and HCOOH (Table 2).…”

Section: Hplc and Uplc (Or Uhplc) Analysis Of Cannabis Consumer Productsmentioning

confidence: 99%

“…Since the publication of the review article 2 on the application of HPLC and UPLC (or UHPLC) methods in the analysis of phytocannabinoids covering the period of 2010–2019, several publications have appeared in the literature on this topic 12–185 . All these publications highlight the importance of HPLC and UPLC (or UHPLC) techniques as well as showcase remarkable advancements in sensitivity and versatility associated with these techniques in relation to phytocannabinoid analysis 12 .…”

Section: Hplc and Uplc (Or Uhplc) Analysis Of Phytocannabinoidsmentioning

confidence: 99%

“…A large volume of HPLC and UPLC (or UHPLC) methods that have been reported for the analysis of cannabinoids in C. sativa L. plant samples 13–94 and cannabis consumer products, for example, hashish, marijuana, and cannabis oils, 95–137 since 2020 are presented in Tables 1 and 2 and discussed in the following subsections.…”

Section: Hplc and Uplc (Or Uhplc) Analysis Of Phytocannabinoidsmentioning

confidence: 99%

“…These consumer products include smoking products, for example, hashish and marijuana, cannabidiol oil, cannabis oil, cannabis olive oil, infusions and liquids, tinctures, cannabis food products, and cannabis‐containing cosmeceuticals (Table 2). 95–137 In the HPLC and UPLC (or UHPLC) methods, the use of PDA or MS detection technologies has become routine for the analysis of these consumer products 2 . The use of HPLC as opposed to UPLC (or UHPLC) has remained the method of choice during 2020–2023, but the use of UPLC (or UHPLC) has increased considerably over the last few years (Table 2).…”

Section: Hplc and Uplc (Or Uhplc) Analysis Of Phytocannabinoidsmentioning

confidence: 99%

See 2 more Smart Citations

Progress in the analysis of phytocannabinoids by HPLC and UPLC (or UHPLC) during 2020–2023

Nahar,

Chaiwut,

Sangthong

et al. 2024

Phytochemical Analysis

View full text Add to dashboard Cite

IntroductionOrganic molecules that bind to cannabinoid receptors are known as cannabinoids. These molecules possess pharmacological properties similar to those produced by Cannabis sativa L. High‐performance liquid chromatography (HPLC) and ultra‐performance liquid chromatography (UPLC, also known as ultra‐high‐performance liquid chromatography, UHPLC) have become the most widely used analytical tools for detection and quantification of phytocannabinoids in various matrices. HPLC and UPLC (or UHPLC) are usually coupled to an ultraviolet (UV), photodiode array (PDA), or mass spectrometric (MS) detector.ObjectiveTo critically appraise the literature on the application of HPLC and UPLC (or UHPLC) methods for the analysis of phytocannabinoids published from January 2020 to December 2023.MethodologyAn extensive literature search was conducted using Web of Science, PubMed, and Google Scholar and published materials including relevant books. In various combinations, using cannabinoid in all combinations, cannabis, hemp, hashish, C. sativa, marijuana, analysis, HPLC, UHPLC, UPLC, and quantitative, qualitative, and quality control were used as the keywords for the literature search.ResultsSeveral HPLC‐ and UPLC (or UHPLC)‐based methods for the analysis of phytocannabinoids were reported. While simple HPLC‐UV or HPLC‐PDA‐based methods were common, the use of HPLC‐MS, HPLC‐MS/MS, UPLC (or UHPLC)‐PDA, UPLC (or UHPLC)‐MS, and UPLC (or UHPLC)‐MS/MS was also reported. Applications of mathematical and computational models for optimization of protocols were noted. Pre‐analyses included various environmentally friendly extraction protocols.ConclusionDuring the last 4 years, HPLC and UPLC (or UHPLC) remained the main analytical tools for phytocannabinoid analysis in different matrices.

show abstract