Impact of Emulsifier Structure and Concentration on Lipolysis Dynamics and Curcumin Bioaccessibility in the Nanoemulsions Stabilized by Polyglycerol Fatty Acid Esters

Abstract

Polyglycerol fatty acid esters (PGFEs), a type of nonionic surfactants, have been widely used in food industry. However, the effects of the aliphatic chain lengths in PGFEs and the concentrations of PGFEs on digestive profiles in emulsion-based systems are poorly understood. The present study has investigated the physicochemical stability, lipolysis dynamics and curcumin bioaccessibility in the nanoemulsions stabilized by synthesized PGFEs with different aliphatic chains (C 10 -C 18 ) at various concentrations using an in vitro gastrointestinal tract (GIT) model. Shorter aliphatic chain or higher concentrations of PGFEs resulted in smaller droplets in the emulsions before and during digestion. PGFEs concentration had different impacts on lipolysis dynamics of nanoemulsions depending on the aliphatic chain lengths of PGFEs. Furthermore, long aliphatic chain of PGFEs contributed to a greater rate and extent of lipolysis, but a lower bioaccessibility of curcumin compared with medium ones, which was attributed to the formation of insoluble calcium soaps induced by calcium ions. These results are expected to facilitate the application of PGFEs for developing optimized nanoemulsions in encapsulating poorly water-soluble nutraceuticals in functional food industry. Supplementary Information The online version contains supplementary material available at 10.1007/s11483-021-09681-z.

Hyaluronic Acid Poly(glyceryl)10-Stearate Derivatives: Novel Emulsifiers for Improving the Gastrointestinal Stability and Bioaccessibility of Coenzyme Q10 Nanoemulsions

“…However, at longer times, the lipid droplets could be fully digested, which may be because the bile acids were able to displace the original emulsifiers from the lipid droplet surfaces . Second, the degree of lipid hydrolysis largely depends on the aggregation state of droplets exposed in the intestinal stage, with more aggregated droplets potentially leading to slower lipid digestion. , The properties of the interfacial layers of PG10-C18@Q10-NE and HA-PG10-C18@Q10-NE are different (Figures and ). In the post-digestion stage of the small intestine, the particle size of PG10-C18@Q10-NE increased rapidly, while the particle size of HA-PG10-C18@Q10-NE changed less (211.1 ± 1.0 to 381.5 ± 2.3 nm vs. 267.7 ± 5.1 to 377.8 ± 2.6 nm), indicating the former has aggregation phenomenon while the latter is relatively stable and has less aggregation (Figure A), thus promoting the accessibility of lipase to the surface of droplets and the rate of lipid hydrolysis.…”

Influence of the Oil Structuring System on Lipid Hydrolysis and Bioaccessibility of Healthy Fatty Acids and Curcumin

“…Although curcumin is a hydrophobic bioactive compound, it is incorporated into mixed micelles to a large extent. This incorporation occurs because mixed micelles are formed by the interactions of the FFA and MAG that are released from the oil droplets [35]. Thus, lipid digestibility could lead to the release of a substantial amount of curcumin.…”

Investigation of the stability and gastrointestinal digestion of camellia oleifera oil bodies as a natural delivery system for curcumin

“…In arti cial drug delivery systems, the structure of the carrier emulsion is determined by the constituents and the preparation method, which can affect its digestive properties in the gastrointestinal tract. For example, the oil phase and particle size in emulsions can signi cantly impact the release of curcumin [7,20,21]. There are many studies on synthetic emulsions' composition, structural differences, and digestive properties, such as nanoparticles and hydrogels in the gastrointestinal tract.…”