Impact of embryo replacement depth on in vitro fertilization and embryo transfer outcomes

Can the Movement of the Air Bubbles After Embryo Transfer Predict the Success of IVF Treatment?

“…According to the outcomes of studies that focused on the potential effect of embryo replacement depth on IVF outcomes, fundal transfer is associated with the highest PRs. In a retrospective analysis of 5,055 USguided ETs, Tıras et al found that when air bubbles were sonographically closer to the fundus, ongoing PRs were higher [9]. Furthermore, in our previous study, we also demonstrated that clinical PRs appeared higher in cases with air bubbles closer to the fundus, and a distance of <10 mm from the fundal endometrial surface seems likely to be the optimal position of the air bubbles for successful ET.…”

“…Studies that have evaluated optimal ET depth within the uterine cavity reported that fundal embryo transfer is associated with the highest pregnancy rates (PRs) but this lacks a consensus [9][10][11]. However, movement of air bubbles after ET may affect IVF success and pregnancy outcomes.…”

Effect of the afterloaded external guidance embryo transfer technique on pregnancy rates in single embryo transfer cycles

“…There were no differences in the baseline parameters like, day 3 FSH and E2, antral follicle count, duration of the stimulation, total dose of gonadotropin, number of oocytes retrieved and 2 PN, and fertilization rates. In our study, all transfers are performed under ultrasound guidance and at a fixed distance of 1 cm from the fundus which is the favored location according to recent studies (13). The results of the present study show that difficult transfers were associated with a lower clinical pregnancy rate (CPR) compared to easy transfers and afterloading, but this did not reach statistical significance.…”

SubEndometrial Embryo Delivery (SEED) with Egg Donation – Mechanical Embryo Implantation

“…This list includes ultrasound-controlled transcervical intrauterine transfer or transmyometrial transfer and more invasive procedures, often referred to as surgical ET, which include: gamete intra-fallopian transfer (GIFT), zygote intra-fallopian transfer (ZIFT), pronuclear stage transfer and embryo intrafallopian transfer (EIFT) (14)(15)(16)(17). Although ultrasound guided ET was desired to improve successful pregnancy outcomes and reduce side effects, it has been received with mixed results (18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32). It also requires simultaneous coordination of two professionals, the physician who performs the transfer and the ultrasonographer (29).…”