Impact of Elevated Serum Uric Acid Levels on Systemic Inflammation in Patients With Psoriasis

Abstract

Patients with psoriasis have increased systemic inflammation and serum uric acid (SUA) levels compared with the general population. However, the role of SUA in modulating inflammation in these patients is not known. We evaluated the associations of SUA with inflammation and psoriasis severity; 199 patients with psoriasis and 54 healthy volunteers were included in the study. Demographic features, Psoriasis Area and Severity Index (PASI) scores, and laboratory data including SUA, C-reactive protein (CRP), and neutrophil to lymphocyte ratio (NLR) were collected. Patients with psoriasis had higher fasting blood glucose, body mass index (BMI), CRP, SUA, white blood cell (WBC) count, neutrophil count, and NLR compared with controls. The PASI score positively correlated only with CRP ( r = .185, P = .012) and NLR ( r = .313, P < .001). The BMI, WBC count, PASI score, and CRP, but not SUA, appeared as independent associates of NLR in patients with psoriasis in linear regression analysis. Neutrophil to lymphocyte ratio and SUA were significantly increased in patients with psoriasis compared with controls. Neutrophil to lymphocyte ratio and CRP were independent predictors of PASI score, whereas SUA was not. Serum uric acid seemed not to modulate the inflammation seen in patients with psoriasis in our cohort.

A Prospective Cross-Sectional Analysis of Construct Validity for the PALMPASS, A Brief Patient-Reported Outcome Measure for Psoriasis

“…17 Decreased CRP levels have been reported in patients with psoriasis effectively treated with tumor necrosis factor-α antagonists, including infliximab or adalimumab. 18 A significant correlation between the PASI and CRP levels ( r = .19, P = .01) reported in a recent study 19 closely matched the correlation we obtained with the 2-item PALMPASS ( r = 0.13, P = .02), further validating our tool. Together, these findings suggest a potential role for the PALMPASS in guiding management, including treatment response.…”

Neutrophil-lymphocyte ratio and platelet-lymphocyte ratio as an alternative to C-reactive protein in diagnostics of inflammatory state in patients with psoriasis

“…According to Solak et al [21], both CRP level and NLR are promising predictors of inflammation in psoriasis (compared with the control group). In their study, PLR was not assessed and psoriatic arthritis was not considered.…”

“…There are also a few studies which investigate simple markers, viz. NLR, PLR, and MPV in patients with psoriasis [21][22][23][24].…”

Association Between Serum Uric Acid Level and Psoriasis: A Case Control Study

“…In our study the mean SUA of psoriasis based on PASI Score with ≤10, 10.1-20 and >20 were observed to be 4.77±0.85 mg/dl, 5.33±1.36 mg/dl and 5.82±1.97 mg/ dl respectively, which is in increasing order as severity increases. Likewise, in a study done by Solak et al 11 mean PASI was 14.4 ± 7.8 and 8.7 ±7.5 respectively.…”