Impact of ecDNA: A mechanism that directs tumorigenesis in cancer drug Resistance-A review

Ashique, Sumel; Upadhyay, Aakash; Garg, Ashish; Mishra, Neeraj Kumar; Hussain, Afzal; Negi, Poonam; Goh, Bey Hing; Bhatt, Shvetank; Ali, Khadem; Kuppusamy, Gowthamarajan; Singh, Sachin Kumar; Gupta, Gaurav; Chellappan, Dinesh Kumar; Dua, Kamal

doi:10.1016/j.cbi.2022.110000

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“…The eccDNAs are notorious for promoting cancer progress and contributing to drug resistance, and even are influential upon tissue development [6] , [20] , [52] . In this study, we constructed eccBase as the first database to date integrating all known eccDNAs from hsa , mmu , gga and sce ( Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Subsequently, the application of electron microscopy and high-throughput sequencing showed that eccDNAs are ubiquitous in eukaryotes, such as Mus musculus ( mmu ) and Saccharomyces cerevisiae ( sce ) [3] , [4] . Regarding how eccDNA is generated, previous studies have proposed multiple potential models, including the DSBs (Double-Strand Breaks), BFB (Breakage-Fusion-Bridge) cycle, translocation-deletion-amplification, and Chromothripsis [5] , [6] . Recently, Yuangao Wang et.al.…”

Section: Introductionmentioning

confidence: 99%

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