Impact of Early-Life Stress and Resilience on Patients with Major Depressive Disorder

Seok, Jeong Ho; Lee, Kyoung‐Uk; Kim, Won; Lee, Seung Hwan; Kang, Eun-Jin; Ham, Byung Joo; Yáng, Jīng; Chae, Jeong Ho

doi:10.3349/ymj.2012.53.6.1093

Cited by 49 publications

(32 citation statements)

References 27 publications

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“…Among post‐traumatic sequelae, depression and PTSD are the two most common mental health conditions (Ying, Wu, Lin, & Jiang, ). In several correlational studies examining trauma exposure and psychological sequelae, resilience has been negatively associated with depressive symptoms (Kukihara, Yamawaki, Uchiyama, Arai, & Horikawa, ; Rainey, Petrey, Reynolds, Agtarap, & Warren, ; Schulz et al, ; Seok et al, ; Spies & Seedat, ; Ying et al, ; Youssef, Green, Dedert et al, ) and the prediction of PTSD status/diagnosis (Fjeldheim et al, ; Lee, Ahn, Jeong, Chae, & Choi, ; Wrenn et al, ; Ying et al, ). These studies presented consistent findings that imply resilience can buffer the effects of trauma exposure on mental health.…”

Section: Resilience As a Potential Moderator Of Trauma's Negative Impactmentioning

confidence: 99%

Resilient Coping Moderates the Effect of Trauma Exposure on Depression

Sinclair

Wallston

Strachan

2016

Research in Nursing & Health

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Posttraumatic depression rates are increasing in the United States, and there is a great need to identify malleable factors that could moderate posttraumatic depression levels. The purpose of this study was to examine whether resilient coping moderates the effects of trauma exposure on depression, while controlling for neuroticism-an established predictor of depressive symptoms. This study used data from 3,734 pairs of twins from the community-based University of Washington Twin Registry. Each twin pair was randomized with twin A in one subsample and twin B in the second subsample. The four-item Brief Resilient Coping Scale measured resilient coping. The two-item Patient Health Questionnaire measured depression. Multiple linear regression analyses were performed on each subsample, controlling for neuroticism. In addition to significant effects of neuroticism and trauma exposure on depression (p < .001), the effect of the interaction of resilient coping and trauma exposure on depression was significant in both subsamples (p < .01). High levels of resilient coping were associated with lower depression scores in the context of previous trauma exposure. Individuals high in resilient coping who experienced significant life traumas were less depressed after trauma exposure, even after controlling for neuroticism. Because coping skills may be learned, interventions that teach resilient coping to individuals with traumatic histories merit investigation. © 2016 Wiley Periodicals, Inc.

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Section: Resilience As a Potential Moderator Of Trauma's Negative Impactmentioning

confidence: 99%

Resilient Coping Moderates the Effect of Trauma Exposure on Depression

Sinclair

Wallston

Strachan

2016

Research in Nursing & Health

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“…Since the early 2000s, several studies have uncovered risk factors, or possible reasons, associated with depression among Koreans, including the lack of family support (Kaneko, Motohashi, Sasaki, & Yamaji, ; Kim & Sohn, ), having poorer self‐reported health status and/or multiple chronic diseases (Huang, Dong, Lu, Yue, & Liu, , ), and living alone (Kim & Sohn, ). Additionally, early‐life stress caused by childhood exposure to abuse, neglect, and violence is considered a long‐lasting risk factor for depression among Koreans (Pechtel & Pizzagalli, ; Seok et al., ). Among adults aged 60 or older, identified risk factors include cognitive impairment, lack of social support, being female, lower educational status, and lower health status (Kim & Sohn, ; Kim et al., ).…”

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confidence: 99%

Is Health Literacy Associated With Depressive Symptoms Among Korean Adults? Implications for Mental Health Nursing

Rhee

Lee

Kim

et al. 2016

Perspect Psychiatr Care

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“…Moreover, only one-third of the risk for developing MDD is inherited, while the remaining two thirds are of environmental influence (Saveanu and Nemeroff, 2012;Sullivan et al, 2000). Stress, early-life experiences, physical abuse and parental violence are all powerful environmental factors that can dramatically alter resilience against future adverse events and thus influence the vulnerability to develop depression, which may or may not be dependent on a genetic predisposition (Mill and Petronis, 2007;Saveanu and Nemeroff, 2012;Seok et al, 2012;Southwick and Charney, 2012). Accordingly, a multitude of studies have identified a variety of genetic polymorphisms as risk factors, therefore placing MDD as a prototypical case of gene × environment interactions (Mandelli and Serretti, 2013).…”

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confidence: 99%

Epigenetic mechanisms underlying the role of brain-derived neurotrophic factor in depression and response to antidepressants

Duclot

Kabbaj

2015

Journal of Experimental Biology

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Major depressive disorder (MDD) is a devastating neuropsychiatric disorder encompassing a wide range of cognitive and emotional dysfunctions. The prevalence of MDD is expected to continue its growth to become the second leading cause of disease burden (after HIV) by 2030. Despite an extensive research effort, the exact etiology of MDD remains elusive and the diagnostics uncertain. Moreover, a marked inter-individual variability is observed in the vulnerability to develop depression, as well as in response to antidepressant treatment, for nearly 50% of patients. Although a genetic component accounts for some cases of MDD, it is now clearly established that MDD results from strong gene and environment interactions. Such interactions could be mediated by epigenetic mechanisms, defined as chromatin and DNA modifications that alter gene expression without changing the DNA structure itself. Some epigenetic mechanisms have recently emerged as particularly relevant molecular substrates, promoting vulnerability or resilience to the development of depressive-like symptoms. Although the role of brainderived neurotrophic factor (BDNF) in the pathophysiology of MDD remains unclear, its modulation of the efficacy of antidepressants is clearly established. Therefore, in this review, we focus on the epigenetic mechanisms regulating the expression of BDNF in humans and in animal models of depression, and discuss their role in individual differences in vulnerability to depression and response to antidepressant drugs. KEY WORDS: BDNF, Epigenetics, Individual differences IntroductionMajor depressive disorder (MDD) is a common debilitating disorder (Bromet et al., 2011) affecting many aspects of the patient's life and family. In addition to its high comorbidity with other neuropsychiatric conditions and increased rate of suicide, depression has a variety of socioeconomic consequences, including low education, unstable employment, reduced work performance and marital dysfunction (Kessler and Bromet, 2013). In 2000, the economic costs of depression in the United States alone were estimated at $83.1 billion, encompassing direct medical costs, suicide-related mortality costs, as well as indirect workplace costs (Greenberg et al., 2003). Moreover, the prevalence of depressive disorders is expected to continue its growth and become by the year 2030 the second leading cause of disease burden among the World Health Organization member states (Mathers and Loncar, 2006). Despite extensive research efforts in past decades, the etiology of REVIEW Department of Biomedical Sciences, Neuroscience Program, Florida State University, Tallahassee, FL 32306, USA.*Author for correspondence (mohamed.kabbaj@med.fsu.edu) depression remains elusive, its diagnosis uncertain and the pharmacotherapy inefficient. Indeed, the antidepressants currently used, which target the monoaminergic pathways, require weeks to months of treatment and exhibit very poor or no response in nearly 50% of patients (Magni et al., 2013;Trivedi et al., 2006;Warden et al., 20...

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Impact of Early-Life Stress and Resilience on Patients with Major Depressive Disorder

Cited by 49 publications

References 27 publications

Resilient Coping Moderates the Effect of Trauma Exposure on Depression

Resilient Coping Moderates the Effect of Trauma Exposure on Depression

Is Health Literacy Associated With Depressive Symptoms Among Korean Adults? Implications for Mental Health Nursing

Epigenetic mechanisms underlying the role of brain-derived neurotrophic factor in depression and response to antidepressants

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