Impact of early childhood trauma on retention and phase advancement in an outpatient buprenorphine treatment program

Abstract

The results from a convenience sample participating in a university-based buprenorphine treatment program demonstrated significant association between self-reported early childhood trauma and retention during the first 90 days. These findings suggest that addressing early trauma could potentially improve adherence rates leading to reduced disease burden. This study extends the knowledge base on potential predictive factors associated with successful participation in outpatient buprenorphine treatment. (Am J Addict 2016;25:542-548).

Buprenorphine medication-assisted treatment during pregnancy: An exploratory factor analysis associated with adherence

“…Adherent women had more days in treatment and more scheduled appointments compared to the other two groups that did not seem to be impacted by gestational time of enrollment. Our previous study in a non-pregnant population suggested that early childhood trauma was associated with adherence (Kumar et al 2016); however, it was inconclusive that a history of childhood trauma or co-morbid psychiatric illnesses impacted adherence to treatment during pregnancy. Of importance, the majority of the women in this study did have a co-morbid psychiatric illness (range 71–100%) and childhood trauma (averaging low to moderate levels across all trauma types) that is congruent with biopsychosocial development models of substance use disorders.…”

Feasibility and Preliminary Efficacy of Isradipine During Outpatient Buprenorphine Stabilization and Detoxification: A Pilot Randomized, Placebo-Controlled Trial

“…23−25 Traditional methods of detoxification from opioids, including tapering off the opioid agonist methadone or buprenorphine and supportive treatment of symptomatology with the α2-adrenergic receptor agonists clonidine or lofexidine, as well as subsequent treatment with the injectable formulation of the opioid antagonist naltrexone (Vivitrol TM ) for relapse prevention, are limited not only by high relapse rates but also lack of efficacy in relieving subjective symptoms of cravings and withdrawals. 26-37 Thus, exploring other detoxification strategies involving opioids is of great importance, not only for opioid-dependent pain patients and prescription opioid abusers, but also for providing a smooth transition from opioid agonists to naltrexone therapy or a drug-free state.…”

Childhood Trauma, Cognitive Emotion Regulation and Motivation for Behavior Change Among Clients of Opioid Substitution Treatment With and Without Past Year Synthetic Cathinone Use During Therapy

“…Regarding the subpopulation of OST clients, early childhood trauma has been linked to poorer treatment retention in OST programs (Kumar et al, 2016), childhood sexual abuse was found to be a predictor of drug use during OST (Schiff et al, 2010), while NPS use among treatment seeking opioid dependent patients was evaluated as an attempt of self-medication for earlier psychological trauma (Gittins et al, 2018). Additionally, OST patients with a history of childhood trauma show impaired ability to associate a stimulus with its outcome when the stimuli is presented in a drug-related context (Weiss et al, 2019), hence clients' cognitive efficacy might be reduced by drug-related stimuli.…”