Impact of early adversity on glucocorticoid regulation and later mental disorders

Strüber, Nicole; Strüber, Daniel; Roth, Gerhard

doi:10.1016/j.neubiorev.2013.10.015

Cited by 164 publications

(143 citation statements)

References 292 publications

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“…The exact effect of OXT on limbic-prefrontal network may be much more complicated on a micro-circuity level. For example, it has been suggested that OXT inhibits activity in the amygdala via its interaction with the GABAergic and serotonergic system within different nuclei of the amygdala complex (Strüber et al, 2014). Although our findings associate the limbic-prefrontal circuit with the stress-attenuating effect of OXT on a macro-network scale, further cellular biological research is needed to elucidate the effect of OXT on a micro-circuitry level.…”

Section: Discussionmentioning

confidence: 59%

“…As the perception and recall of ELS are influenced by various factors, including personality traits and coping skills, it is important to acknowledge the subjectivity in our measurement of EA when interpreting the findings. Previous studies showed differential effects of ELS on stress reactivity in a gender-and age-specific manner, depending on the specific type and severity of ELS, as well as the presence/absence of concurrent stress and psychiatric symptoms (Heim and Binder, 2012;Strüber et al, 2014). In the present study, we recruited only healthy young male subjects and used EA as the main predictor in our multiple regression models.…”

Section: Discussionmentioning

confidence: 98%

“…These findings associate increased amygdala-hippocampal coupling with dysregulated HPA stress reactivity, especially aberrant glucocorticoid negative feedback. Substantial evidence associates ELS with dysregulated cortisol stress responses and HPA reactivity (Strüber et al, 2014). It has recently been found that ELS can induce epigenetic modification in the hippocampus, which is related to deficiency in HPA regulation via glucocorticoid negative feedback (Klengel et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…It has been found that different subtypes of ELS have differential impact on stress reactivity and stress-related affective disorders (Carpenter et al, 2009;Strüber et al, 2014). For example, unlike other subtypes of ELS, EA is a particularly strong predictor for blunt HPA reactivity, dampened cortisol stress responses, and internalizing psychopathology, such as major depression and social anxiety (Carpenter et al, 2009;Grimm et al, 2014;Keyes et al, 2012).…”

Section: Assessment Of Elsmentioning

confidence: 99%

“…Cumulative stress early in life comprises a spectrum of adverse social experiences that occur before puberty, including sexual, physical, and emotional forms of abuse, as well as physical and emotional neglect (Pechtel and Pizzagalli, 2011). Ample evidence supports that early life stress (ELS) has enduring impact on the neuroendocrine system and leads to dysregulated cortisol responses to psychosocial stress in adulthood (Strüber et al, 2014). Such ELS-associated changes in stress reactivity have been associated with the development of depressive and anxiety disorders later in life (McEwen, 2003).…”

Section: Introductionmentioning

confidence: 99%

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Amygdala–Hippocampal Connectivity Changes During Acute Psychosocial Stress: Joint Effect of Early Life Stress and Oxytocin

Fan

Pestke

Feeser

et al. 2015

Neuropsychopharmacol

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Previous evidence shows that acute stress changes both amygdala activity and its connectivity with a distributed brain network. Early life stress (ELS), especially emotional abuse (EA), is associated with altered reactivity to psychosocial stress in adulthood and moderates or even reverses the stress-attenuating effect of oxytocin (OXT). The neural underpinnings of the interaction between ELS and OXT remain unclear, though. Therefore, we here investigate the joint effect of ELS and OXT on transient changes in amygdala-centered functional connectivity induced by acute psychosocial stress, using a double-blind, randomized, placebo-controlled, within-subject crossover design. Psychophysiological interaction analysis in the placebo session revealed stress-induced increases in functional connectivity between amygdala and medial prefrontal cortex, posterior cingulate cortex, putamen, caudate and thalamus. Regression analysis showed that EA was positively associated with stress-induced changes in connectivity between amygdala and hippocampus. Moreover, hierarchical linear regression showed that this positive association between EA and stress-induced amygdala-hippocampal connectivity was moderated after the administration of intranasal OXT. Amygdala-hippocampal connectivity in the OXT session correlated negatively with cortisol stress responses. Our findings suggest that altered amygdala-hippocampal functional connectivity during psychosocial stress may have a crucial role in the altered sensitivity to OXT effects in individuals who have experienced EA in their childhood.

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Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Assessment Of Elsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Amygdala–Hippocampal Connectivity Changes During Acute Psychosocial Stress: Joint Effect of Early Life Stress and Oxytocin

Fan

Pestke

Feeser

et al. 2015

Neuropsychopharmacol

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Self‐Regulation and Developmental Psychopathology: Experiential Canalization of Brain and Behavior

Blair

Raver²,

Finegood

2016

Developmental Psychopathology

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We use principles of developmental science and the concept of experiential canalization as a lens through which to view the development of self‐regulation in childhood and risk for the development of psychopathology. Problems with the regulation of emotion, attention, the stress response, and executive functions are characteristic of many psychiatric disorders. Experiential canalization provides a framework within which to examine interactions among processes of self‐regulation across multiple levels of analysis from the genetic to the social and cultural. A focus on self‐regulation illuminates a developmental analysis of risk for psychopathology and also processes of resilience in response to risk. We review the historical understanding of experiential canalization in the scientific literature, examining its initial representation through to its manifestation in current thinking about processes of epigenesis. We then present a comprehensive model of self‐regulation and apply it to research literatures on the development of depression, anxiety, attention deficit hyperactivity disorder, and schizophrenia. In keeping with central concepts in developmental science, we highlight the ways that self‐regulation can best be understood in terms of reciprocal interactions among genetic, physiological, perceptual, cognitive, affective, behavioral and social‐cultural processes and consider the ways in which behavior plays a central organizing role in development with implications for both stability and change. We conclude with an examination of resilience as an instance of the experiential canalization of self‐regulation and resulting considerations for prevention and intervention.

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DNA methylation at stress‐related genes is associated with exposure to early life institutionalization

Non

Hollister

Humphreys

et al. 2016

American J Phys Anthropol

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Objectives Differences in DNA methylation have been associated with early life adversity, suggesting that alterations in methylation function as one pathway through which adverse early environments are biologically embedded. This study examined associations between exposure to institutional care, quantified as the percent time in institutional care at specified follow-up assessment ages, and DNA methylation status in two stress-related genes: FKBP5 and SLC6A4. Materials and Methods We analyzed data from the Bucharest Early Intervention Project, which is a prospective study in which children reared in institutional settings were randomly assigned (mean age 22 months) to either newly created foster care or care as usual (to remain in their current placement) and prospectively followed. A group of children from the same geographic area, with no history of institutionalized caregiving, were also recruited. DNA methylation status was determined in DNA extracted from buccal epithelial cells of children at age 12. Results An inverse association was identified such that more time spent in institutional care was associated with lower DNA methylation at specific CpG sites within both genes. Discussion These results suggest a lasting impact of early severe social deprivation on methylation patterns in these genes, and contribute to a growing literature linking early adversity and epigenetic variation in children.

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Impact of early adversity on glucocorticoid regulation and later mental disorders

Cited by 164 publications

References 292 publications

Amygdala–Hippocampal Connectivity Changes During Acute Psychosocial Stress: Joint Effect of Early Life Stress and Oxytocin

Amygdala–Hippocampal Connectivity Changes During Acute Psychosocial Stress: Joint Effect of Early Life Stress and Oxytocin

Self‐Regulation and Developmental Psychopathology: Experiential Canalization of Brain and Behavior

DNA methylation at stress‐related genes is associated with exposure to early life institutionalization

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