Impact of dry hydrogen peroxide on hospital-acquired infection at a pediatric oncology hospital

Melgar, Mario; Ramirez, Marylin; Chang, Andrew; Antillón, Federico

doi:10.1016/j.ajic.2021.12.010

Cited by 7 publications

(6 citation statements)

References 30 publications

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“…Based on research from Dartini et al (2017), it was mentioned that using chlorine solution as a disinfection material on radiographic cassettes is effectively 2% better than using alcohol with a content of 70%. In this study, researchers used betel leaf oil with the consideration that it is a natural ingredient, easy to obtain in Indonesia, and the use of local wisdom as a material of value in the community, besides that because it is a natural ingredient, it will not provide side effects in the form of irritation to the skin or damage the surface on the radiographic cassettes (Emrizal et al, 2014;Rahayu et al, 2019;Melgar et al, 2022;Thi et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

“…There are limitations in data collection in hospitals. Then, the radiographic cassette used as a research sample was in the Purwokerto Radiology Study Program Laboratory (Melgar et al, 2022;Trunga et al, 2021), whose use is only by students for practice in the lab. This is likely to cause the number of microbes that exist when research needs to be more accurate according to the number of radiographic cassettes commonly used in patient services at the Radiology Installation.…”

Section: Discussionmentioning

confidence: 99%

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Betel Leaf Oil as a Natural Disinfection Agent in Radiological Equipment (Study of Microbial Quantity of Radiographic Cassette)

et al. 2023

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Background: Betel leaf oil is a wonderful natural antiseptic. Betel leaf oil is rich in polyphenols, especially chavicol, which can be used to protect against microbe pathogens that cause infection. The cause of the spread of nosocomial infections in radiology can occur using a radiographic cassette. Previous research has found that radiographic cassette contains microorganisms and fungi. Purpose: To determine the effectiveness of using betel leaf oil as a natural disinfection on a radiographic cassette. Method: Quasi-experimental research with pre-test and post-test design designs was carried out by calculating the number of microbes, including Total Plate Count (TPC), Staphylococcus, and fungi. The study on 12 conventional radiographic cassettes was calculated using the swab method before and after cleaning with betel leaf oil. The data were analyzed descriptively to illustrate the rate of decline. Result: The results showed that the percentage rate of decline after the radiographic cassette was cleaned with betel leaf oil was ALT (17.8%), Staphylococcus (57.41%), and fungi (37.21%). Conclusion: Betel leaf oil can be used as alternative natural disinfection on radiographic cassettes, quite effectively suppressing the activity and number of microbes present.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Betel Leaf Oil as a Natural Disinfection Agent in Radiological Equipment (Study of Microbial Quantity of Radiographic Cassette)

et al. 2023

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“…Similarly, hydrogen peroxide technologies have been shown to reduce C. difficile infection rates within paediatric settings. One study illustrated a statistically significant reduction in Clostridioides -associated gastroenteritis when dry hydrogen peroxide was used as a cleaning adjunct compared to the control unit [85]. Hydrogen peroxide is well understood to be effective at reducing environmental loading of C. difficile spores, however additional research into their application within paediatric settings is required [81].…”

Section: Indirect Transmission Risksmentioning

confidence: 99%

Clostridioides difficile detection and infection in children: are they just small adults?

Watkin,

Yongblah,

Burton

et al. 2024

Journal of Medical Microbiology

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Clostridioides difficile is a well-recognized healthcare-associated pathogen, with its significance widely recognized in adult populations. Despite this, there is limited data on the significance of detection within paediatric populations, both for individual patient management and wider transmission risk-based considerations. High rates of colonization are understood to occur in infants, with increasing levels up to 11 months, and colonization rates similar to adults by 8 years old. Sources of C. difficile are ubiquitous, with detection in companion animals and food sources, as well as within the clinical and wider environment. Due to the close interactions that occur between children and the environment, it is understandable that increasing recognition is afforded to the community acquisition of C. difficile in children. Other risk factors for the detection of C. difficile in children are similar to those observed in adults, including prior hospitalization and underlying conditions affecting gut health and motility. Recent studies have shown rising awareness of the role of asymptomatic carriage of C. difficile in healthcare transmission. Prior to this, paediatric patient populations were less likely to be screened due to uncertainty regarding the significance of detection; however, this increased awareness has led to a review of possible carriage testing pathways. Despite this increased attention, C. difficile infection remains poorly defined in paediatric populations, with limited dedicated paediatric data sets making comparison challenging. This is further complicated by the fact that infection in children frequently self resolves without additional therapies. Due to this, C. difficile remains a management challenge in paediatric settings.

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“…1 Due to the potential for such infections to be transmitted widely with serious consequences, hospitals have established infection tracking and surveillance systems in place, along with robust prevention strategies to reduce the rate of hospital-acquired infections. [2][3][4] Beginning in 2013, peracetic acid (PAA)-based disinfectants were introduced into a number of hospitals because of their superior ability to eliminate Clostridium difficile and other dangerous pathogens. Confirmation of this efficacy was recently demonstrated in a study showing that hospital-wide surface hygiene protocols with a PAA-based surface disinfectant containing active ingredients PAA (0.13%) and hydrogen peroxide (HP, 0.64%) reduced hospital-acquired Clostridioides difficile infections by 50% on average in a study across 8 hospitals over 3 years.…”

mentioning

confidence: 99%

Environmental chamber studies of eye and respiratory irritation from use of a peracetic acid–based hospital surface disinfectant

Dalton

Mauté²,

Hicks³

et al. 2023

ASHE

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Objective: To characterize personal exposures and measures of eye and respiratory tract irritation in controlled environmental chamber studies of 44 healthy adult volunteers simulating upper-bound use of peracetic acid (PAA)–based surface disinfectant for terminal cleaning of hospital patient rooms. Design: Experimental, within-subject, double-blinded cross-over design. Methods: Objective and subjective exposure effects were assessed for PAA and its components: acetic acid (AA) and hydrogen peroxide (HP). Deionized water was included as a control. Breathing-zone concentrations of PAA, AA, and HP were assessed for 8 female multiday volunteers (5 consecutive days) and 36 single-day volunteers (32 females and 4 males). Wetted cloths were used to wipe high-touch surfaces for 20 minutes per trial. Also, 15 objective measures of tissue injury or inflammation and 4 subjective odor or irritation scores were assessed. Results: Disinfectant trials showed 95th percentile breathing zone concentrations of 101 ppb PAA, 500 ppb AA, and 667 ppb HP. None of the volunteers observed over 75 test days exhibited significant increases in IgE or objective measures of eye and respiratory tract inflammation. Subjective ratings for disinfectant and AA-only trials showed similar increases for odor intensity and nose irritation, with lower ratings for eye and throat irritation. Females were 2.5-fold more likely than males to assign moderate + irritation ratings. Conclusions: Simulated upper-bound hospital use of PAA-based disinfectant led to no significant increases in objective markers of tissue injury, inflammation, or allergic sensitization, and no frank signs of eye or respiratory tract irritation.

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Impact of dry hydrogen peroxide on hospital-acquired infection at a pediatric oncology hospital

Cited by 7 publications

References 30 publications

Betel Leaf Oil as a Natural Disinfection Agent in Radiological Equipment (Study of Microbial Quantity of Radiographic Cassette)

Betel Leaf Oil as a Natural Disinfection Agent in Radiological Equipment (Study of Microbial Quantity of Radiographic Cassette)

Clostridioides difficile detection and infection in children: are they just small adults?

Environmental chamber studies of eye and respiratory irritation from use of a peracetic acid–based hospital surface disinfectant

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