Impact of drug-eluting stents with different coating strategies on stent thrombosis: A meta-analysis of 19 randomized trials

Abstract

Background: Whether drug-eluting stents with biodegradable polymers (BP-DES) improve safety, especially with respect to stent thrombosis (ST) compared with permanent polymers DES (PP-DES (OR 0.33;) compared with PP-DES. There were no significant differences between the groups regarding MI incidence and mortality during both short and long follow-up periods. In stratified analyses, the long-term superiority of BP-DES was maintained only by using first-generation DES as the comparators. Conclusions: The present meta-analysis indicated that BP-DES were more efficacious than PP-DES at reducing the risks of very late ST and long-term TLR, but it could vary by heterogeneities in the use of PP-DES comparators. Additional rigorous RCTs with longer follow-upperiods are warranted to verify these very promising long-term endpoints. (Cardiol J 2014; 21, 5: 557-568)

Safety and efficacy profile of bioresorbable‐polylactide‐polymer‐biolimus‐A9‐eluting stents versus durable‐polymer‐everolimus‐ and zotarolimus‐eluting stents in patients with acute coronary syndrome

“…Interestingly, BES versus second‐generation DES showed higher rates of definite ST than CoCr‐EES . On the other hand, the beneficial outcomes regarding late lumen loss and late ST after biodegradable‐polymer‐DES versus durable‐polymer‐DES have been documented in the meta‐analysis made by Lupi et al Significantly lower risk of very late ST in biodegradable‐polymer‐BES versus durable polymer DES has been reported by Ye and Niu X et al . In both studies, heterogenous‐DES‐comparators were used in different patient subsets, which could fundamentally influence safety and efficacy results .…”

“…The comparison of different DES is further complicated by various stent variants used . As such, delayed strut endothelialization as a trigger of ST depends on the polymer, strut structure and thickness and drug load .…”

SLM Produced Porous Titanium Implant Improvements for Enhanced Vascularization and Osteoblast Seeding

“…Chemotactic factors as the herein evaluated can be incorporated into polymers on surfaces of the implant material. Thereby a directed release over time can be achieved leading to an enhanced factor concentration into the area of interest [ 38 , 39 ]. EDX and ESEM analyses showed in this study complete surface covering of PCL on the coated titanium implants.…”

Remote ischaemic conditioning in percutaneous coronary intervention: a meta-analysis of randomised trials

“…Sensitivity analyses were conducted to assess the consistency of the main results by testing whether consecutively deleting each trial would influence the overall estimates for the myocardial enzyme levels. A study was considered to be influential if its exclusion changed the effect estimate by at least 20% [ 29 ]. All findings were also repeated using a fixed-effect model, and only the data from high-quality studies were analysed.…”