Impact of donor ABH‐secretor status in ABO‐mismatched living donor kidney transplantation

Drexler, Beatrice; Holbro, Andreas; Sigle, Joerg P.; Gassner, Christoph; Frey, Beat M.; Schaub, Stefan; Amico, Patrizia; Plattner, Alexandra; Infanti, Laura; Menter, Thomas; Mihatsch, Michael J.; Stangel, Martin; Buser, Andreas; Dickenmann, Michael

doi:10.1111/trf.13711

Cited by 2 publications

(4 citation statements)

References 29 publications

(54 reference statements)

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“…Pertaining to this point, the results of previous studies are contradictory. Drexler et al believed that patients who received kidney transplantation from a secretor donor underwent significant improvement in early renal function after transplantation, with a significant impact on humoral rejection (16). However, Kim et al found that soluble ABH antigens produced by grafts from secretor donors did not affect renal function and graft rejection in recipients (17).…”

Section: Discussionmentioning

confidence: 99%

“…Drexler et al. believed that patients who received kidney transplantation from a secretor donor underwent significant improvement in early renal function after transplantation, with a significant impact on humoral rejection ( 16 ). However, Kim et al.…”

Section: Discussionmentioning

confidence: 99%

“…After ABOi kidney transplantation, renal grafts can secrete soluble A/B/H antigens into the blood of recipients according to the donor’s secretor status ( 15 ). However, the influence of the secretion status of donors/recipients on recipient accommodation remains controversial ( 16 , 17 ). In this study, we investigated the correlation between the secretion status of donors/recipients and the prognosis of ABOi transplantation.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Donor and Recipient ABH-Secretor Status on ABO-Incompatible Living Donor Kidney Transplantation

et al. 2021

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IntroductionABO blood group antigens within grafts are continuously exposed to anti-A/B antibodies in the serum of recipients after ABO-incompatible (ABOi) kidney transplantation and are instrumental in antibody-mediated rejection. Some individuals secrete soluble blood group antigens into body fluids. In this study, we investigated the effect of donor and recipient secretor status on the outcomes of ABOi kidney transplantation.MethodsData of a total of 32 patients with ABOi living donor kidney transplantation were retrospectively collected between 2014 and 2020 in West China Hospital. The genotype and phenotype of both donors and recipients were examined and evaluated with post-transplantation anti-A/B titer changes, graft function, and rejection.ResultsOf the 32 recipients and 32 donors, 23 (71.9%) recipients and 27 (84.4%) donors had secretor genotypes, whereas 9 (28.1%) recipients and 5 (15.6%) donors did not. Anti-A/B titers after ABOi kidney transplantation were not significantly influenced by the secretor status of either donors or recipients. The post-transplantation serum creatinine (Scr) levels and estimated glomerular filtration rate (eGFR) was better in weak- or non-secretor recipients at day 30 (Scr P = 0.047, eGFR P = 0.008), day 90 (Scr P = 0.010, eGFR P = 0.005), and month 9 (eGFR P = 0.008), and recipients from secretor donors had a lower incidence of graft rejection in the first year after ABOi transplantation (P = 0.004).ConclusionsA weak secretor status phenotype was found in both genotypes, i.e., individuals who secreted soluble antigens as well as those who did not. The recipient ABH-secretor status may have an influence on early posttransplant renal function, and the donor ABH-secretor status might affect the incidence of graft rejection.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of Donor and Recipient ABH-Secretor Status on ABO-Incompatible Living Donor Kidney Transplantation

et al. 2021

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“…Like A and B antigens, soluble forms of Le b but not Le a are also found in the saliva and urine (secretor). Whist the significance of secretor status is currently cryptic, there appear to be links between this, host defences [14] and graft outcomes [15] at least in ABO blood group status. Unlike naturally occurring AB antibodies which are almost ubiquitous, not all individuals have innate anti-Le antibodies with antibodies generally being found in individuals who are Le a-b-.…”

Section: Author Manuscriptmentioning

confidence: 99%

The potential role of antibodies against minor blood group antigens in renal transplantation

et al. 2020

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Impact of donor ABH‐secretor status in ABO‐mismatched living donor kidney transplantation

Abstract: The donor ABH-secretor status may have an influence on early posttransplant renal function in patients undergoing ABO-mismatched living donor kidney transplantation. Further prospective studies with long-term follow-up are needed to elucidate involved pathomechanisms.

Cited by 2 publications

References 29 publications

Effect of Donor and Recipient ABH-Secretor Status on ABO-Incompatible Living Donor Kidney Transplantation

Effect of Donor and Recipient ABH-Secretor Status on ABO-Incompatible Living Donor Kidney Transplantation

The potential role of antibodies against minor blood group antigens in renal transplantation

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