Impact of disease in dairy cows on ceftiofur pharmacokinetics, withdrawal times and emergence of antimicrobial resistance

Gorden, Patrick J.

doi:10.31274/etd-180810-5765

Cited by 2 publications

(2 citation statements)

References 105 publications

(292 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To some extent, the PNV is in direct proportion of the specificity and the actual proportion of tank milk free of contaminants which is high in developed dairy countries. A recent publication reports that only 0.011% of tankers contained violative levels of β‐lactams in the USA,25 and the same situation is observed in France with only 575 tanks found positive to inhibitors in 2015 on 6 million tested, 26. Conversely, the predictive positive value (PPV) which, to some extent, combines the CC β and the actual prevalence of contamination, is poor and false positive results are numerous.…”

Section: Discussionmentioning

confidence: 79%

Assessment of ceftiofur residues in cow milk using commercial screening test kits

Durel

Gallina²,

Pellet

2019

Veterinary Record Open

View full text Add to dashboard Cite

Ceftiofur, a third-generation cephalosporin, is one of the most used antibiotics in dairy industry. Intramuscular injection of 1 mg/kgBW ceftiofur hydrochloride (HCl) generally results in 0 hour withdrawal time for the milk in dairy cows. Nevertheless, farmers and dairy processors occasionally complain about ceftiofur-based products in case of positive result to a commercial rapid screening test for the presence of violative residues of antimicrobials (inhibitors) in the bulk milk tank. Six lactating cows were injected with a 50 mg/ml ceftiofur HCl-based product at the dosage regimen of 1 mg/kg, intramuscularly, once a day, for five consecutive days, as per label. Milk samples were then collected just before the very last injection (T0) and then at 12, 24, 36, 48, 60, 72, 84 and 96 hours after the last injection. Individual milk samples were tested using three commercial screening test kits for inhibitor residues: DelvotestSP NT, SNAP Beta-Lactam ST Plus and ROSA MRL Beta-Lactam Test. Since bulk tank is screened in real operating conditions, samples were also diluted to 1:4, 1:10 and tested again. For the Delvotest SP NT, which lowest detected concentration is close the MRL of the ceftiofur (100 µg/kg), all results were negative. For the ROSA MRL Beta-Lactam Test and the SNAP Beta-Lactam ST Plus, several samples yielded positive and doubtful results at T0 and T12. However, after dilution to 1:10, all results were negative. Consequently, when used as officially instructed, the tested 50 mg/ml ceftiofur HCl-based injectable veterinary products are safe, and milk should be free of violative residues of ceftiofur. With consideration to the low specificity and the low positive predictive value of commercial screening tests, positive reactions of the bulk milk should be interpreted as false positive or another risky usage of β-lactam-based medicines in the farm must be investigated.

show abstract

Section: Discussionmentioning

confidence: 79%

Assessment of ceftiofur residues in cow milk using commercial screening test kits

Durel

Gallina²,

Pellet

2019

Veterinary Record Open

View full text Add to dashboard Cite

show abstract

“…Ceftiofur, a third-generation cephalosporin, is effective against Gram-positive and Gram-negative bacteria, including beta-lactamase-producing strains (GORDEN, 2017).…”

Section: Introductionmentioning

confidence: 99%

Correlation Between Plasma Concentration of Vilocci, a Ceftiofur Formulation, and Minimum Inhibitory Concentration Values of Zootechnical Interest Microorganisms in Cattle and Pigs

FECHIS,

MARCHIORI FILHO,

LEONELO NETO

et al. 2024

Ars Vet

View full text Add to dashboard Cite

Ceftiofur is a third-generation cephalosporin widely used in cattle and swine farming to treat respiratory and reproductive conditions. The veterinary pharma industry consistently develops new formulations with this molecule to bring highly effective products to market with short withdrawal periods, ensuring consumer safety for products derived from treated animals. This study aimed to evaluate the plasma concentration profile of Vilocci, a new formulation of ceftiofur, in comparison to the minimum inhibitory concentrations (MIC) of various pathogens commonly found in bovine and swine farming. Ten animals from each species were used, and a single dose of 1 mg/kg was given to bovines and 5 mg/kg to swine. Blood samples were collected at 12 time points to construct the pharmacokinetic profile. In addition, the minimum inhibitory concentration (MIC) of growth for the pathogens of interest isolated from the target species was determined. The effectiveness of Vilocci (Ceftiofur hydrochloride 50mg/mL) against each of the evaluated pathogens was also assessed.

show abstract

Impact of disease in dairy cows on ceftiofur pharmacokinetics, withdrawal times and emergence of antimicrobial resistance

Cited by 2 publications

References 105 publications

Assessment of ceftiofur residues in cow milk using commercial screening test kits

Assessment of ceftiofur residues in cow milk using commercial screening test kits

Correlation Between Plasma Concentration of Vilocci, a Ceftiofur Formulation, and Minimum Inhibitory Concentration Values of Zootechnical Interest Microorganisms in Cattle and Pigs

Contact Info

Product

Resources

About