Impact of Disease Activity on Physical Activity in Patients With Psoriatic Arthritis

Abstract

Objective. The purpose of this study was to compare physical activity (PA) in a group of patients with psoriatic arthritis (PsA) versus healthy controls and to determine whether the mobility of these patients is affected by disease activity.Methods. A group of 52 patients with PsA and 53 controls were included in this case-control study. PA was assessed by accelerometry in both groups and additionally with the International Physical Activity Questionnaire (IPAQ) in patients with PsA. Multiple regression analysis was used to compare PA between groups and to determine the relationship between PA and PsA features, including disease activity, as assessed by the 28-joint Disease Activity Score (DAS28) and the Disease Activity Index for Psoriatic Arthritis (DAPSA) score. In a group of 36 patients, a testretest study was carried out after 6 months.Results. The time engaged in moderate-to-vigorous physical activity (MVPA) per day, as evaluated by accelerometry, and adjusted by confounders, proved similar in patients with PsA and controls. In patients with PsA, disease activity was inversely related to PA as assessed either by IPAQ or accelerometry. When PA was compared in patients with PsA between the 2 visits, a significant difference in the amount of time doing MVPA was found (42 ± 33 versus 30 ± 22 minutes/day; P = 0.004). Interestingly, in the test-retest study, variations in disease activity over time based on DAPSA scores (r = -0.49, P = 0.002) and DAS28 using the C-reactive protein level (r = -0.4, P = 0.017) were inversely correlated with changes in PA, as determined by accelerometry.Conclusion. Patients with PsA show levels of PA like healthy controls. In patients with PsA, disease activity and PA are inversely correlated and the evaluation of PA by accelerometry is sensitive to changes in disease activity.

Associations between cardiovascular risk factors, disease activity and cardiorespiratory fitness in patients with inflammatory joint disease: a cross-sectional analysis

“…Notably, patients with IJD tend to be less physically active and present with inferior levels of CRF compared to healthy peers [13][14][15][16]. Patients with increased disease activity may gravitate towards a sedentary lifestyle and, over time, physical inactivity can precipitate a decline in CRF [17][18][19][20]. The relationship between disease activity and CRF has not been extensively investigated, and given that both low levels of CRF and an elevated inflammatory burden may increase CVD risk in IJD, the potential association between disease activity and CRF warrants further investigation.…”

Actigraphy-derived physical activity levels and circadian rhythm parameters in patients with psoriatic arthritis: relationship with disease activity, mood, age and BMI

“… 1 There has been one previous actigraphy study exploring PA in PsA which demonstrated comparable PA levels between PsA and healthy controls with a secondary analysis showing reduced PA in patients with increased disease activity, as measured with the DAPSA score which is further supported by the current findings. 32 Mechanistically, the increased risk of CVD in PsA has been explained by chronic low-level inflammation leading to endothelial dysfunction and dyslipidaemia. 1 , 2 The findings from this cohort study would support further longitudinal research investigating level and type of exercise on incidence of CVD, factoring in the impact of disease severity.…”

Analysis of physical activity in psoriatic arthritis: relationship with clinical and analytical parameters and comorbidity—description of the sedentary patient

“…In addition, better mood was related to physical activity ( 13 ). Similarly, another study found an inverse relationship between physical activity, measured using accelerometry and a physical activity questionnaire, and disease activity ( 14 ).…”

“…Bivariate correlations were calculated between physical activity and DAPSA (and components), HAQ, FACIT-F, PSAID, BMI, HADS-A, HADS-D, and ISI. The linear regression model was performed with exercise as the dependent variable and as independent variables those that had been significant in the univariate analysis and those that, according to the literature, had influenced physical activity (age, sex, BMI, TJC, VAS pain, HADS-A, HADS-D, FACIT-F, and ISI) ( 13 , 14 , 31 ).…”

“…On the other hand, two groups of patients were established according to the definition of a sedentary lifestyle, and comparisons were made in demographic variables, clinical characteristics, activity, functionality, impact, and comorbidities between both groups of patients. Similarly, a logistic regression model was performed using sedentary lifestyle as the dependent variable and as independent variables those that had been significant in the univariate analysis and those that, according to the literature, had influenced physical activity (age, sex, enthesitis, TJC, SJC, VAS pain, BMI, HADS-A/HADS-D, FACIT-F, and ISI) ( 13 , 14 , 31 ).…”