Impact of direct-acting antivirals on neuropsychiatric and neurocognitive dysfunction in chronic hepatitis C patients

Shehata, Ghaydaa A.; Ahmed, Gellan K.; Hassan, Elham Ahmed; Rehim, Abeer Sharaf El-Din Abdel; Mahmoud, Saad Z.; Masoud, Noha Ali; Seifeldein, Gehan S.; Hassan, Waleed Attia; Aboshaera, Khaled O.

doi:10.1186/s41983-022-00568-5

Cited by 5 publications

(1 citation statement)

References 70 publications

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“…HCV was associated with executive function, psychomotor speed, memory, and attention deficits. Interestingly patients that achieved SVR (i.e., viral cure) with HCV treatment did not show improvements in their performance on neuropsychological testing, contrary to what had been reported prior ( Barbosa et al, 2017 ; Shehata et al, 2022 ; Tan et al, 2022 ). The authors of this study postulated that differences in attention deficits may relate to systemic inflammation, but no mechanistic work was done to support this suggestion ( Tan et al, 2022 ).…”

Section: Liver-brain Axis In Clinical Diseasecontrasting

confidence: 73%

Avenues within the gut-liver-brain axis linking chronic liver disease and symptoms

Nguyen

Swain

2023

Front. Neurosci.

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Symptoms of fatigue, social withdrawal and mood disturbances are commonly encountered in patients with chronic liver disease and have a detrimental effect on patient quality of life. Treatment options for these symptoms are limited and a current area of unmet medical need. In this review, we will evaluate the potential mechanistic avenues within the gut-liver-brain axis that may be altered in the setting of chronic liver disease that drive the development of these symptoms. Both clinical and pre-clinical studies will be highlighted as we discuss how perturbations in host immune response, microbiome, neural responses, and metabolites composition can affect the central nervous system.

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Section: Liver-brain Axis In Clinical Diseasecontrasting

confidence: 73%

Avenues within the gut-liver-brain axis linking chronic liver disease and symptoms

Nguyen

Swain

2023

Front. Neurosci.

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Effect of gender difference on psychiatric outcomes for hepatitis C virus patients receiving direct-acting antivirals in Egyptian population: a cohort study

Mahran

Khalifa

Makhlouf

et al. 2022

Egypt J Neurol Psychiatry Neurosurg

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Background Chronic liver disease is primarily caused by hepatitis C virus (HCV). HCV produces extrahepatic psychiatric problems. So, patients with CHC who received sofosbuvir-based direct-acting antiviral agents (DAAs) were evaluated for psychiatric manifestations, specifically depression and anxiety symptoms. Additionally, evaluate the impact of gender on psychiatric manifestations of sofosbuvir-based DAAs and identify their potential risk factors for psychiatric manifestations. In this prospective study, 170 CHC patients without prior treatment received DAA therapy who categorized into 2 groups, group 1 comprised male participants (Nb = 97), and group two comprised female participants (Nb = 73). All participants were evaluated with the five-factor model of personality (SIFFM), Hamilton Depression Rating Scale (HDS), and Hamilton Anxiety Rating Scale (HAS) at baseline and repeated follow up until 3 months after treatment end. Results Our findings indicated that, a progressive decline in the mean HADS-A and HADS-D scores between baseline (before treatment) and consequence follow-up (during and after treatment) measurements without significant difference regarding gender. No statistically significant difference between the groups regarding the mean values of SIFFM. High levels of extraversion were more likely to increase depression levels. Conclusions DAA treatment significantly improved anxiety and depression symptoms in CHC patients. Gender did not affect sofosbuvir-based DAA psychiatric symptoms. High extraversion increased depression risk.

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Bridging the gap: associations between gut microbiota and psychiatric disorders

Ahmed,

Ramadan,

Elbeh

et al. 2024

Middle East Curr Psychiatry

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Background Gut microbiota plays a pivotal role in the gut-brain axis and can influence neurodevelopment and mental health outcomes. This review summarizes the current evidence on the associations between gut microbiota alterations and various psychiatric illnesses. Main body The composition of the gut microbiome evolves from birth through old age, and disruptions during critical periods may increase disease risk. Factors like diet, medications, stress, and infections can disturb the gut microenvironment and lead to dysbiosis. Dysbiosis has been linked to conditions like depression, anxiety, autism, ADHD, and schizophrenia. Proposed mechanisms involve microbial regulation of neurotransmitters, inflammation, oxidative stress, blood-brain barrier permeability, and the immune system. Therapeutic strategies like probiotics, prebiotics, and faecal transplantation may modulate the gut-brain axis and microbial ecosystem. However, more research is needed to elucidate the causal microbiota-psychiatry relationship. Understanding gut-brain interactions may uncover new possibilities for preventing and managing psychiatric disorders. Conclusion A growing body of research points to a close relationship between gut microbiota and mental health. While the field is still emerging, dysbiosis of gut microbial ecosystem has been associated with various neuropsychiatric conditions. The underlying mechanisms likely involve the microbiota-gut-brain axis signalling pathways. Additional research with larger samples is required to establish causal links between specific microbial changes and psychiatric outcomes.

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Impact of direct-acting antivirals on neuropsychiatric and neurocognitive dysfunction in chronic hepatitis C patients

Cited by 5 publications

References 70 publications

Avenues within the gut-liver-brain axis linking chronic liver disease and symptoms

Avenues within the gut-liver-brain axis linking chronic liver disease and symptoms

Effect of gender difference on psychiatric outcomes for hepatitis C virus patients receiving direct-acting antivirals in Egyptian population: a cohort study

Bridging the gap: associations between gut microbiota and psychiatric disorders

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