Impact of different syringe pumps on red cells during paediatric simulated transfusion

Pardo, Larissa Perez; Peterlini, Maria Angélica Sorgini; Tume, Lyvonne N.

doi:10.1111/nicc.12561

Cited by 4 publications

(5 citation statements)

References 28 publications

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“…Despite their benefits, the safety of this equipment in blood transfusions remains to be proven [25]; many studies have shown that SIPs can cause red cell damage during blood administration, increasing the rate of hemolysis [26]. According to health service policy, staff using volumetric infusion pumps must demonstrate knowledge and competency in using such pumps.…”

Section: Transfusion By Syringe Infusion Pumps (Sips)mentioning

confidence: 99%

Assessment of transfusion practices in pediatrics: A case report

Ilham¹,

Abdelkader²

2022

Int J Blood Transfus Immunohematol

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Introduction: Pediatric patients should not be exposed to blood components and products unnecessarily. Transfusion-related risks are always present, both those we know and those that remain to be discovered. It is essential to follow good transfusion practice (GTP) procedures; although they can sometimes be quite prescriptive, evidence shows that when we ignore guidelines, errors can occur. Case Report: We report the case of a 7-month-old infant who underwent surgery for megacolon and received emergency transfusions. The death of the infant post-surgery prompted a hemovigilance investigation to determine the imputability of the transfusion. Conclusion: The investigation revealed deficiencies in the patientandrsquo;s transfusion management, some of which were critical. This indicates that nurses have a considerable knowledge deficit in blood transfusion; however, the infantandrsquo;s death was not attributable to transfusion and was due to post-surgical complications.

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Section: Transfusion By Syringe Infusion Pumps (Sips)mentioning

confidence: 99%

Assessment of transfusion practices in pediatrics: A case report

Ilham¹,

Abdelkader²

2022

Int J Blood Transfus Immunohematol

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“…Although syringe and peristaltic pumps are frequently used because of their robust flow control capabilities and compatibility with standardized components (e.g., syringes, fittings, and tubing), they can be challenging to integrate into confined environments 18 . In addition, the mechanical oscillations of the screw or cam mechanism can introduce undesired flow pulsations that result in cell damage 19 – 22 .…”

Section: Introductionmentioning

confidence: 99%

A miniaturized 3D printed pressure regulator (µPR) for microfluidic cell culture applications

Hsu

Mansouri

Ahamed

et al. 2022

Sci Rep

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Well-defined fluid flows are the hallmark feature of microfluidic culture systems and enable precise control over biophysical and biochemical cues at the cellular scale. Microfluidic flow control is generally achieved using displacement-based (e.g., syringe or peristaltic pumps) or pressure-controlled techniques that provide numerous perfusion options, including constant, ramped, and pulsed flows. However, it can be challenging to integrate these large form-factor devices and accompanying peripherals into incubators or other confined environments. In addition, microfluidic culture studies are primarily carried out under constant perfusion conditions and more complex flow capabilities are often unused. Thus, there is a need for a simplified flow control platform that provides standard perfusion capabilities and can be easily integrated into incubated environments. To this end, we introduce a tunable, 3D printed micro pressure regulator (µPR) and show that it can provide robust flow control capabilities when combined with a battery-powered miniature air pump to support microfluidic applications. We detail the design and fabrication of the µPR and: (i) demonstrate a tunable outlet pressure range relevant for microfluidic applications (1–10 kPa), (ii) highlight dynamic control capabilities in a microfluidic network, (iii) and maintain human umbilical vein endothelial cells (HUVECs) in a multi-compartment culture device under continuous perfusion conditions. We anticipate that our 3D printed fabrication approach and open-access designs will enable customized µPRs that can support a broad range of microfluidic applications.

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“…Although syringe and peristaltic pumps are frequently used due to their robust flow control capabilities and compatibility with standardized components (e.g., syringes, fittings, and tubing), they can be challenging to integrate into confined environments. In addition, the mechanical oscillations of the rotary motor or cam mechanism can introduce undesired flow pulsations that result in cell damage (Pardo et al 2020; Kurth et al 2019; Kusahara et al 2015; Wilson et al 2016). Pneumatic pumping schemes create a defined pressure drop (Δ P ) across microfluidic networks to drive fluid flows.…”

Section: Introductionmentioning

confidence: 99%

A Miniaturized 3D-Printed Pressure Regulator (μPR) for Microfluidic Cell Culture Applications

Hsu

Mansouri

Ahamed

et al. 2022

Preprint

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Controlled fluid flows are the hallmark feature of microfluidic culture systems and provide precise definition over the biophysical and biochemical microenvironment. Flow control is commonly achieved using displacement-based (e.g., syringe or peristaltic pumps) or pressure-based techniques. These methods offer complex flow capabilities but can be challenging to integrate into incubators or other confined environments due to their large form factors and accompanying peripheral equipment. Since many microfluidic cell culture studies use a single controlled flow rate to maintain or stimulate cells, a portable flow control platform that fits easily into an incubator will benefit the microfluidic community. Here, we demonstrate that a tunable, 3D printed micro pressure regulator (μPR), combined with a battery-powered miniature air pump, can operate as a stand-alone pneumatic flow control platform for microfluidic applications. We detail the design and fabrication of the μPR and demonstrate: i) a tunable outlet pressure range relevant for microfluidic applications (1-10 kPa), ii) highlight dynamic control in a microfluidic network, and iii) maintain human umbilical vein endothelial cells (HUVECs) in a multi-compartment, membrane-based culture device under continuous flow conditions. We anticipate that our 3D-printed fabrication approach and open access designs will allow other laboratories to rapidly customize μPRs to support a broad range of applications.

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Impact of different syringe pumps on red cells during paediatric simulated transfusion

Cited by 4 publications

References 28 publications

Assessment of transfusion practices in pediatrics: A case report

Assessment of transfusion practices in pediatrics: A case report

A miniaturized 3D printed pressure regulator (µPR) for microfluidic cell culture applications

A Miniaturized 3D-Printed Pressure Regulator (μPR) for Microfluidic Cell Culture Applications

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