Impact of different surgical margin conditions on local recurrence of oral squamous cell carcinoma

Kitamura, Hiroshi; Nakanishi, Yoshitaka; Nishizawa, Rishiho; Xiao, Tiepeng; Kamata, Toshihide; Koike, Takeshi; Kobayashi, H

doi:10.1016/j.oraloncology.2010.08.014

Cited by 95 publications

(81 citation statements)

References 13 publications

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“…The results of this study showed that a deep surgical margin had a significant impact on local recurrence, DSS, and RFS, as seen in previous studies [6,29,[39][40][41]. Some studies have identified an association between the margin status and factors that impact outcome in oral cancer, including the T status, N status, DOI, and POI [6,39,41].…”

Section: Discussionsupporting

confidence: 82%

“…Some studies have identified an association between the margin status and factors that impact outcome in oral cancer, including the T status, N status, DOI, and POI [6,39,41]. In this study, POI and NAC were significantly associated with a closed deep surgical margin.…”

Section: Discussionmentioning

confidence: 50%

“…In our study, NAC increased the local recurrence rate over that in patients without NAC. An increase in the risk of local recurrence by NAC has not previously been reported but, in some studies on local recurrence, the local recurrence rate was higher in patients with NAC than in those without NAC, although the difference was not significant [37,39]. Okura et al demonstrated that NAC was associated with a significant increase in regional failure for patients with OSCC with N0 disease [37].…”

Section: Discussionmentioning

confidence: 98%

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Predictors of Locoregional Recurrence in T1-2N0 Tongue Cancer Patients

Yanamoto

Yamada

Takahashi

et al. 2013

Pathol. Oncol. Res.

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Locoregional recurrence of oral tongue squamous cell carcinoma (OTSCC) has been considered a poor prognostic entity in terms of survival rate.The purpose of this study was to evaluate the incidence of locoregional recurrence and to identify significant risk factors for locoregional recurrence in early-stage OTSCC. We retrospectively reviewed the records of 58 patients who underwent radical surgery for T1-2N0 OTSCC. The local recurrence and regional recurrence rates were 10.3% (6/58 patients) and 15.5% (9/58 patients) in this study, respectively. The survival rate of patients with local recurrence was 66.7%, which was significantly lower than that (96.2%) of patients without local recurrence, whereas the survival rates of patients with or without regional recurrence were not significantly difference. Pattern of invasion (POI), neoadjuvant chemotherapy (NAC) and the status of the surgical margin were identified as factors influencing local recurrence. In particular, the status of the deep surgical margin was a high potential independent risk factor. The deep surgical margin was resected closely in many NAC-treated cases, suggesting that NAC may lead to local recurrence and a poor outcome. No efficacy of NAC was observed, suggesting that the standard treatment for early OTSCC is surgery alone.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 50%

Section: Discussionmentioning

confidence: 98%

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Predictors of Locoregional Recurrence in T1-2N0 Tongue Cancer Patients

Yanamoto

Yamada

Takahashi

et al. 2013

Pathol. Oncol. Res.

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“…Through induction of T cell apoptosis, the Fas-FasL system has been shown to play a role in eliminating harmful immunologic responses. Thus, the Fas-FasL pathway may, at least in part, play a role in tumor evasion of the immune system by inducing T cell apoptosis in tumor-infiltrating lymphocytes (TIL) (Hub et al, 1997;Kurita et al, 2010). In this report, both Fas(Data not shown) and FasL were found to be expressed in TIL and tumor cells.…”

Section: Discussionmentioning

confidence: 54%

Effects of FasL Expression in Oral Squamous Cell Cancer

Sun²,

Hu³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…The prognostic significance of surgical margin for LR of head and neck cancer and oral tongue cancer has been reported [1,[14][15][16] and it was confirmed as a risk factor when \5 mm of margin status was encountered even though the patients had postoperative adjuvant therapy. Tumor thickness has been considered to correlate with cervical lymph node metastasis but there is no clear consensus of how to measure depth or thickness and also the decisive cut-off level for elective neck treatment.…”

Section: Discussionmentioning

confidence: 87%

Impact of Clinical and Histo-Pathological Prognostic Factors on T1-2N0-1 Oral Tongue Carcinoma

Sittitrai

Srivanitchapoom

Mahanupab

et al. 2012

Indian J Otolaryngol Head Neck Surg

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To determine predictive factors which affect local and regional recurrence of T1-2N0-1M0 oral tongue carcinoma (OTC). Records of 42 patients with T1-2N0-1 M0 OTC were reviewed. The clinical characteristics, histopathological data, disease recurrence and survival rate were analyzed. Descriptive statistics and Kaplan-Meier survival analysis were used. The median follow up was 38 months. The 2-year overall survival and disease-free survival rates were 85.7 and 55.6 % respectively. At the 2 year analysis, there were surgical margin\5 mm (p value = 0.01), tumor thickness [7 mm (p value = 0.03), perivascular and perilymphatic invasion (p value = 0.01) affected on local recurrence and perivascular and perilymphatic invasion were also predictors for regional recurrence (p value = 0.04). The surgical margin status, tumor thickness, perivascular and perilymphatic invasion represented significant predictive factors for local recurrent OTC. Postoperative adjuvant therapy should be considered in these groups.

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Impact of different surgical margin conditions on local recurrence of oral squamous cell carcinoma

Cited by 95 publications

References 13 publications

Predictors of Locoregional Recurrence in T1-2N0 Tongue Cancer Patients

Predictors of Locoregional Recurrence in T1-2N0 Tongue Cancer Patients

Effects of FasL Expression in Oral Squamous Cell Cancer

Impact of Clinical and Histo-Pathological Prognostic Factors on T1-2N0-1 Oral Tongue Carcinoma

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