Impact of different spacers on the conjugation between Anderson-Evans polyoxometalates and peptides
Haihong Yu,
Claudia Honisch,
Mattia Frigo
et al.
Abstract:The Anderson-Evans polyoxometalates (POM) display a promising anticancer activity. The conjugation with the GRP-receptor antagonist peptide Demobesin (fQWAVGHL-NHEt) was exploited to impart cell targeting capabilities and improve the selectivity of such polyanions. However, the POM interacts with the grafted peptides, inducing chains folding and self-assembly of the resulting hybrids, thus decreasing their recognition ability. Within this context, a tailored spacer, including two domains, i.e., a hydrophilic o… Show more
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