Impact of different ionic strengths on protein-lipid co-oxidation in whey protein isolate-stabilized oil-in-water emulsions

Chen, Jiaxin; Cao, Chuanai; Yuan, Dongxue; Xia, Xiufang; Liu, Qian; Kong, Baohua

doi:10.1016/j.foodchem.2022.132700

Cited by 15 publications

(2 citation statements)

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“…Moreover, the presence of NaCl decreased the CI values of the emulsions stabilized by PGCs except BBG-TA. The concentration of the adsorbed proteins in the oil–water interfacial layer in the emulsions decreased with the increasing ionic strength ( Chen, et al, 2022 ). Therefore, the CI values of the emulsions decreased with the increasing NaCl concentrations (Zhang, Ding, et al, 2020).…”

Section: Resultsmentioning

confidence: 99%

Effects of polyphenol and gelatin types on the physicochemical properties and emulsion stabilization of polyphenol-crosslinked gelatin conjugates

Wu,

Shi,

et al. 2024

Food Chemistry: X

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Section: Resultsmentioning

confidence: 99%

Effects of polyphenol and gelatin types on the physicochemical properties and emulsion stabilization of polyphenol-crosslinked gelatin conjugates

Wu,

Shi,

et al. 2024

Food Chemistry: X

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“…It was reported that the ionic strength has a strong influence on the surface hydrophobicity, solubility, spatial structure of a protein molecule, as well as its interfacial amount on the oil droplet surface. 48,49 The surface hydrophobicity of protein increases with an increase of ionic strength of the media, and by these means, the stability of WPI interfacial layer also increases.…”

Section: Resultsmentioning

confidence: 99%

Mucoadhesive Emulsion Microgels for Intravesical Drug Delivery: Preparation, Retention at Urothelium, and Biodistribution Study

Saveleva,

Lobanov,

Gusliakova

et al. 2023

ACS Appl. Mater. Interfaces

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The intravesical instillation procedure is a proven method in modern urology for the treatment of bladder diseases. However, the low therapeutic efficiency and painfulness of the instillation procedure are significant limitations of this method. In the present study, we propose an approach to solving this problem by using microsized mucoadhesive macromolecular carriers based on whey protein isolate with the possibility of prolonged release of drugs as a drug delivery system. The optimal water-to-oil ratio (1:3) and whey protein isolate concentration (5%) were determined to obtain emulsion microgels with sufficient loading efficiency and mucoadhesive properties. The droplet diameter of emulsion microgels varies from 2.2 to 3.8 μm. The drug release kinetics from the emulsion microgels was evaluated. The release of the model dye in saline and artificial urine in vitro was observed for 96 h and reached up to 70% of loaded cargo for samples. The effect of emulsion microgels on the morphology and viability of two cell lines was observed: L929 mouse fibroblasts (normal adherent cells) and THP-1 human monocytes (cancer suspension cells). Developed emulsion microgels (5%, 1:3 and 1:5) showed sufficient mucoadhesion to a porcine bladder urothelium ex vivo. The biodistribution of emulsion microgels (5%, 1:3 and 1:5) in mice (n = 3) after intravesical (instillation) and systemic (intravenous) administration was assessed in vivo and ex vivo using nearinfrared fluorescence live imaging for real time. It was demonstrated that intravesical instillation allows approximately 10 times more efficient accumulation of emulsion microgels in the mice urinary bladder in vivo 1 h after injection compared to systemic injection. The retention of the emulsion of mucoadhesive microgels in bladders after the intravesical instillation was observed for 24 h.

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Mass transfer study on noncovalent adsorption and desorption of soluble phenolics by plant cell wall materials for green purification

Ma,

Zhu,

et al. 2024

Chemical Engineering Journal

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Impact of different ionic strengths on protein-lipid co-oxidation in whey protein isolate-stabilized oil-in-water emulsions

Cited by 15 publications

References 50 publications

Effects of polyphenol and gelatin types on the physicochemical properties and emulsion stabilization of polyphenol-crosslinked gelatin conjugates

Effects of polyphenol and gelatin types on the physicochemical properties and emulsion stabilization of polyphenol-crosslinked gelatin conjugates

Mucoadhesive Emulsion Microgels for Intravesical Drug Delivery: Preparation, Retention at Urothelium, and Biodistribution Study

Mass transfer study on noncovalent adsorption and desorption of soluble phenolics by plant cell wall materials for green purification

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