Impact of Different Helicobacter pylori Eradication Therapies on Gastrointestinal Symptoms

Abstract

Background and Objectives: Helicobacter pylori (H. pylori) infection impairs quality of life. However, whether eradication therapy ameliorates gastrointestinal symptoms remains questionable. The main objective of this study was to evaluate the influence of H. pylori eradication therapy on gastrointestinal symptoms. Materials and Methods: A total of 140 patients, 59 women and 81 men, with a mean age of 61 and suffering from H. pylori infection in the University Hospital of Split, Croatia, were enrolled in the study. Patients were randomly assigned to either concomitant or hybrid therapies. The Gastrointestinal Symptom Rating Scale (GSRS) questionnaire was completed by patients prior to and after the eradication therapy. Results: In both groups, the total GSRS score improved significantly after therapy. In the concomitant group, the abdominal pain score, reflux symptoms score and indigestion score decreased significantly after therapy. In the group with hybrid therapy, all five groups of symptoms (abdominal pain, reflux symptoms, indigestion, diarrhea and constipation) significantly decreased after therapy. Patients with adverse events had significantly higher total GSRS scores after eradication therapy. Conclusions: H. pylori eradication therapy could alleviate gastrointestinal symptoms regardless of the treatment used, but the favorable effect seemed to be more pronounced after hybrid therapy.

Increased Glycated Hemoglobin but Decreased Cholesterol after a Loss of Helicobacter pylori Infection: A Community-Based Longitudinal Metabolic Parameters Follow-Up Study

“…Because of the increasing antibiotic resistance of H. pylori, the eradication rate of clarithromycin-based triple therapy has decreased below 80% [3,33]. Other combinations for eradication therapy, such as concomitant therapy, hybrid and high dose dual therapy have all been used as first-line therapies [34,35]. Some gastrointestinal symptoms, such as reflux symptoms, maldigestion or abdominal pain, and hematologic diseases, such as iron deficiency or thrombocytopenia purpura, may be relieved after eradication therapy [36].…”

Global Trend on Machine Learning in Helicobacter within One Decade: A Scientometric Study

“…H. pylori infection leads to many changes in the gastric mucosa, which can lead to complications such as inflammation, immune dysfunction and apoptosis, mitochondrial changes, aging, and gastric dysbacteriosis [ 48 ]. H. pylori eradication improves the majority of GI symptoms, such as indigestion, abdominal pain, bloating, and decreasing the risk of bleeding in patients with a history of GI bleeding [ 49 , 50 ], thereby enhancing the quality of life [ 50 ].…”

“…Other routes of transmission, such as the consumption of contaminated water or food, may also be involved in the disease's transmission [ 65 ]. This infection and its symptoms can reduce the quality of life in patients [ 50 ]. Besides, its complications may lead to mortality and shortening of life expectancy in patients.…”

Helicobacter pylori infection

“…In a study from Hungary, using the Functional Digestive Disorder Quality of Life system adapted from France to determine QoL in patients with functional dyspepsia, improvement of QoL was dependent on H. pylori therapy 346 . In a study from Croatia, the Gastrointestinal Symptom Rating Scale questionnaire was employed and improvement in QoL of patients with dyspepsia was found as early as 1 month into the year-long study 347 .…”