“…Diet-induced obesity is associated with up-regulation of leptin and down-regulation of adiponectin mRNA along with high expression of mRNA encoding proinflammatory cytokines in adipose tissues. 45 The FTA up-regulated adiponectin mRNA and decreased leptin mRNA expression, although NKS-3 failed to significantly decrease the latter in adipose tissues of HFD-fed mice. Leptin is also a proinflammatory adipokine.…”