Impact of Dietary Lipids on the Reverse Cholesterol Transport: What We Learned from Animal Studies

Papotti, Bianca; Escolà‐Gil, Joan Carles; Julve, Josep; Potì, Francesco; Zanotti, Ilaria

doi:10.3390/nu13082643

Cited by 14 publications

(8 citation statements)

References 201 publications

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“…Furthermore, because of the application of B. coagulans ALM 86 to calves, it was established that the level of total cholesterol decreased by 41.61% in the first experimental group, and by 58.95% in the second, compared to the control group (Wu et al, 2018). Cholesterol levels in the body are associated with cardiovascular disease (Papotti et al, 2021). An increase or decrease in cholesterol can have a negative effect on the health of animals.…”

Section: Table 3 Results Of the Influence Of B Coagulans Alm 86 On Bi...mentioning

confidence: 99%

Determination of the Therapeutic Effect of the Use of Bacillus Coagulans in Calf Dyspepsia

Шкромада¹,

Фотіна²,

BEREZOVSKYI³

et al. 2022

Scientific Horizons

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The relevance of this study lies in the use of the probiotic strain of the microorganism B. coagulans ALM 86 for the treatment of diarrhoea in dairy calves and the reduction of the use of antibiotics in animal husbandry. The purpose of this paper was to establish the therapeutic effect in the treatment of diarrhoea in calves, the composition of the microflora, physiological indicators and metabolism using Bacillus coagulans ALM 86. The study used the following methods: microbiological, microscopic, biochemical, physiological, statistical. Studies have shown that the use of B. coagulans ALM 86 contributes to a decrease in the number of opportunistic microflora E. coli – by 90.8%, S. aureus – by 92.4%, S. enterica – by 88.01, an increase in Lactobacillus sp. by 130.8–151.58% and Bifidobacterium sp. by 272.7–469.8%. Administration of B. coagulans ALM 86 at a concentration of 1×109, CFU/g at a dose of 3–5 g helped stop diarrhoea and accelerate the development of scar digestion for four days in dairy calves, compared to the group where the antibiotic was used. An increase in average daily growth and feed consumption was found in the first experimental group by 19.7–15.0%, in the second – by 23.4–19.9% (р≤0.05). A decrease in the level of total cholesterol with the use of B. coagulans ALM 86, an increase in the level of total protein by 18.57–22.6%, as a result of an increase in the content of total globulins by 49.3–57.37%, respectively (р≤0.05), were proven. Administration of B. coagulans ALM 86 at a concentration of 1×109, CFU/g at a dose of 3–5 g helped stop diarrhoea and accelerate the development of scar digestion for four days in dairy calves, compared to the group where the antibiotic was used. The obtained results of the study indicate the absence of toxic effects of the proposed dose of B. coagulans ALM 86 for the treatment of dyspepsia in calves and obtaining a positive effect. The practical value of the obtained results lies in the possibility of using B. coagulans ALM 86 in the treatment of diarrhoea in dairy calves without the use of antibiotics on animal farms of various designation.

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Section: Table 3 Results Of the Influence Of B Coagulans Alm 86 On Bi...mentioning

confidence: 99%

Determination of the Therapeutic Effect of the Use of Bacillus Coagulans in Calf Dyspepsia

Шкромада¹,

Фотіна²,

BEREZOVSKYI³

et al. 2022

Scientific Horizons

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“…Fatty acyl is classified into three groups based on their aliphatic tail length: short-chain fatty acids (SCFAs) with fewer than 6 carbons (e.g., acetate, butyrate, propionate), medium-chain fatty acids (MCFAs) with 6-12 carbons (e.g., caprylic acid and lauric acid), and LCFAs with 12 or more carbons [50,51]. LCFAs and MCFAs are mainly generated from dietary triglycerides [52], whereas SCFAs are produced through the fermentation of dietary carbohydrates (fiber) by commensal bacteria [1,53].…”

Section: Fatty Acylmentioning

confidence: 99%

Emerging roles of host and microbial bioactive lipids in inflammatory bowel diseases

Kayama

2023

Eur J Immunol

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The intestinal tract harbors diverse microorganisms, host‐ and microbiota‐derived metabolites, and potentially harmful dietary antigens. The epithelial barrier separates the mucosa, where diverse immune cells exist, from the lumen to avoid excessive immune reactions against microbes and dietary antigens. Inflammatory bowel disease (IBD), such as ulcerative colitis and Crohn's disease, is characterized by a chronic and relapsing disorder of the gastrointestinal tract. Although the precise etiology of IBD is still largely unknown, accumulating evidence suggests that IBD is multifactorial, involving host genetics and microbiota. Alterations in the metabolomic profiles and microbial community are features of IBD. Advances in mass spectrometry–based lipidomic technologies enable the identification of changes in the composition of intestinal lipid species in IBD. Because lipids have a wide range of functions, including signal transduction and cell membrane formation, the dysregulation of lipid metabolism drastically affects the physiology of the host and microorganisms. Therefore, a better understanding of the intimate interactions of intestinal lipids with host cells that are implicated in the pathogenesis of intestinal inflammation might aid in the identification of novel biomarkers and therapeutic targets for IBD. This review summarizes the current knowledge on the mechanisms by which host and microbial lipids control and maintain intestinal health and diseases.

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“…Virgin coconut oil showed a beneficial role in lipid metabolism, and the effect on cardiovascular protection was ascribed to its capability to promote macrophage-specific reverse cholesterol transport (RCT). RCT measurement was suggested as a useful biological marker of cardiovascular risk depiction and played a valuable role in anti-atherogenesis [102,103]. Likewise, in a recent in vivo comparative study, virgin coconut oil, due to a vast content in lauric acid, appeared to mediate RCT via upregulation of the hepatic mRNA expression of SRB1 and ABCA1, certainly through the PPAR-α -LXR-α -ABCA1 signaling pathway in macrophages [103].…”

Section: Biological Mechanisms Of Mufa In Cardioprotectionmentioning

confidence: 99%

Essential Fatty Acids as Biomedicines in Cardiac Health

et al. 2021

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The destructive impact of cardiovascular diseases on health, including heart failure, peripheral artery disease, atherosclerosis, stroke, and other cardiac pathological conditions, positions these health conditions as leading causes of increased global mortality rates, thereby impacting the human quality of life. The considerable changes in modern lifestyles, including the increase in food intake and the change in eating habits, will unavoidably lead to an unbalanced consumption of essential fatty acids, with a direct effect on cardiovascular health problems. In the last decade, essential fatty acids have become the main focus of scientific research in medical fields aiming to establish their impact for preventing cardiovascular diseases and the associated risk factors. Specifically, polyunsaturated fatty acids (PUFA), such as omega 3 fatty acids, and monounsaturated fatty acids from various sources are mentioned in the literature as having a cardio-protective role, due to various biological mechanisms that are still to be clarified. This review aims to describe the major biological mechanisms of how diets rich in essential fatty acids, or simply essential fatty acid administration, could have anti-inflammatory, vasodilatory, anti-arrhythmic, antithrombotic, antioxidant, and anti-atherogenic effects. This review describes findings originating from clinical studies in which dietary sources of FAs were tested for their role in mitigating the impact of heart disorders in human health.

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Impact of Dietary Lipids on the Reverse Cholesterol Transport: What We Learned from Animal Studies

Cited by 14 publications

References 201 publications

Determination of the Therapeutic Effect of the Use of Bacillus Coagulans in Calf Dyspepsia

Determination of the Therapeutic Effect of the Use of Bacillus Coagulans in Calf Dyspepsia

Emerging roles of host and microbial bioactive lipids in inflammatory bowel diseases

Essential Fatty Acids as Biomedicines in Cardiac Health

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