Impact of dietary ketosis on volatile anesthesia toxicity in a model of Leigh syndrome
Kira A. Spencer,
Miranda N. Howe,
Michael T. Mulholland
et al.
Abstract:BackgroundGenetic mitochondrial diseases impact over 1 in 4000 individuals, most often presenting in infancy or early childhood. Seizures are major clinical sequelae in some mitochondrial diseases including Leigh syndrome, the most common pediatric presentation of mitochondrial disease. Dietary ketosis has been used to manage seizures in mitochondrial disease patients. Mitochondrial disease patients often require surgical interventions, leading to anesthetic exposures. Anesthetics have been shown to be toxic i… Show more
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