Impact of diet on hydrogen sulfide production: implications for gut health

Teigen, Levi; Biruete, Annabel; Khoruts, Alexander

doi:10.1097/mco.0000000000000881

Cited by 5 publications

(3 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, the autoimmune protocol diet (AID) had a higher subclinical response rate and a lower relapse rate than the control group, which may have been due to changes in the AID group's metabolome and microbiome that reduced inflammation [5]. According to another study, adhering to a strict diet that includes fruits, vegetables, and whole grains while limiting red meat, processed foods, and dairy products can help reduce symptoms and improve the quality of life in patients with UC [35][36][37]. Many IBD patients believe that their diet causes flare-ups and avoid their favorite foods as a result.…”

Section: Discussionmentioning

confidence: 99%

A Systematic Review of the Role of Diet in Ulcerative Colitis

Abbas¹,

Shakil²,

Rana³

et al. 2023

Cureus

View full text Add to dashboard Cite

Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by inflammation and ulceration of the colon and rectum. Diet is an important part of UC management because it can either aggravate or alleviate symptoms along with medication therapy. A comprehensive literature search was conducted using multiple databases (PubMed and Online Wiley Library) and search engines (Google Scholar) using specific keywords related to UC and diet. The search resulted in a large number of articles, which were then narrowed down by focusing on clinical trials and randomized controlled trials published between 2010 and 2023. According to the research, certain dietary interventions, such as the low FODMAP diet, the Mediterranean diet, and the anti-inflammatory diet, appear to improve symptoms and overall quality of life. Dietary interventions have the potential to help with UC management. The goal should be to provide patients with tailored dietary interventions and other treatments to improve their quality of life. More research is needed to identify the most effective dietary interventions and better understand how they work.

show abstract

Section: Discussionmentioning

confidence: 99%

A Systematic Review of the Role of Diet in Ulcerative Colitis

Abbas¹,

Shakil²,

Rana³

et al. 2023

Cureus

View full text Add to dashboard Cite

show abstract

“…By using in vitro tests with human fecal material, it has been found that, for instance, production of H 2 S is greatly enhanced by sulfur-containing amino acids but much more modestly by inorganic sulfate [ 112 ]. In addition, H 2 S production is diminished by fermentable fibers [ 112 ], and there is a positive relationship between dietary protein intake and H 2 S production by the intestinal microbiota [ 113 , 114 ].…”

Section: Amino Acid-derived Bacterial Metabolites Are Involved In The...mentioning

confidence: 99%

Amino Acid-Derived Bacterial Metabolites in the Colorectal Luminal Fluid: Effects on Microbial Communication, Metabolism, Physiology, and Growth

Blachier

2023

Microorganisms

View full text Add to dashboard Cite

Undigested dietary and endogenous proteins, as well as unabsorbed amino acids, can move from the terminal part of the ileum into the large intestine, where they meet a dense microbial population. Exfoliated cells and mucus released from the large intestine epithelium also supply nitrogenous material to this microbial population. The bacteria in the large intestine luminal fluid release amino acids from the available proteins, and amino acids are then used for bacterial protein synthesis, energy production, and in other various catabolic pathways. The resulting metabolic intermediaries and end products can then accumulate in the colorectal fluid, and their concentrations appear to depend on different parameters, including microbiota composition and metabolic activity, substrate availability, and the capacity of absorptive colonocytes to absorb these metabolites. The aim of the present review is to present how amino acid-derived bacterial metabolites can affect microbial communication between both commensal and pathogenic microorganisms, as well as their metabolism, physiology, and growth.

show abstract

“…Hydrogen sulfide is produced by gut microbiota, and it has been proposed as a driver for CRC. A study demonstrated how the changes in gut microbiota composition induced by fibers may reduce the microbial production of hydrogen sulfide, thus reducing the risk of CRC [17]. The enrichment of gut flora of beneficial commensals (such as Clostridiales, Blautia, Roseburia), phenolic metabolites (benzoate and catechol metabolism), and dietary components (ferulic acid-4 sulfate, trigonelline, and salicylate) was correlated with anti-CRC efficacy; the rice bran dietary treatment showed a ∼72% reduction in the incidence of colonic epithelial erosion in a mouse model of inflammation-induced carcinogenesis in this regard [18].…”

Section: Interaction Between Fiber and The Microbiotamentioning

confidence: 99%

Fibres and Colorectal Cancer: Clinical and Molecular Evidence

Celiberto,

Aloisio,

Girardi

et al. 2023

IJMS

View full text Add to dashboard Cite

Colorectal cancer (CRC) is one of the leading causes of mortality for cancer in industrialized countries. The link between diet and CRC is well-known, and presumably CRC is the type of cancer which is most influenced by dietary habits. In Western countries, an inadequate dietary intake of fibers is endemic, and this could be a driving factor in the increase of CRC incidence. Indeed, several epidemiologic studies have elucidated an inverse relationship between daily fiber intake and risk of CRC. Long-term prognosis in CRC survivors is also dependent on dietary fibers. Several pathogenetic mechanisms may be hypothesized. Fibers may interfere with the metabolism of bile acids, which may promote colon carcinogenesis. Further, fibers are often contained in vegetables which, in turn, contain large amounts of antioxidant agents like resveratrol, polyphenols, or phytoestrogens. Moreover, fibers can be digested by commensal flora, thus producing compounds such as butyrate, which exerts an antiproliferative effect. Finally, fibers may modulate gut microbiota, whose composition has shown to be associated with CRC onset. In this regard, dietary interventions based on high-fiber-containing diets are ongoing to prevent CRC development, especially in patients with high potential for this type of tumor. Despite the fact that outcomes are preliminary, encouraging results have been observed.

show abstract

Impact of diet on hydrogen sulfide production: implications for gut health

Cited by 5 publications

References 27 publications

A Systematic Review of the Role of Diet in Ulcerative Colitis

A Systematic Review of the Role of Diet in Ulcerative Colitis

Amino Acid-Derived Bacterial Metabolites in the Colorectal Luminal Fluid: Effects on Microbial Communication, Metabolism, Physiology, and Growth

Fibres and Colorectal Cancer: Clinical and Molecular Evidence

Contact Info

Product

Resources

About