Impact of Diet and Nutrition on Cancer Hallmarks

Chen, Karen L.; Jung, Paul; Kulkoyluoglu-Cotul, Eylem; Liguori, Carli; Lumibao, Jan; Mazewski, Candice; Ranard, Katherine M.; Rowles, Joe L.; Wang, Yanling; Xue, Louisa; Madak-Erdoğan, Zeynep

doi:10.15406/jcpcr.2017.07.00240

Cited by 3 publications

(1 citation statement)

References 142 publications

(148 reference statements)

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“…Diet also has important effects on metabolic profile and LGI, and indeed, the dietary approach enters into the therapeutic path in cancer treatment. Furthermore, bioactive compounds in diet may directly affect both LGI and tumorigenesis [233][234][235]. However, according to a recent review, most of the studies on PA interventions in cancer patients do not properly consider nutritional aspects [236].…”

Section: Effects Of Physical Activity On Adipose Tissue Low-grade Inflammation and Tumor Progressionmentioning

confidence: 99%

Another Weapon against Cancer and Metastasis: Physical-Activity-Dependent Effects on Adiposity and Adipokines

Perego

Sansoni

Ziemann³

et al. 2021

IJMS

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Physically active behavior has been associated with a reduced risk of developing certain types of cancer and improved psychological conditions for patients by reducing anxiety and depression, in turn improving the quality of life of cancer patients. On the other hand, the correlations between inactivity, sedentary behavior, and overweight and obesity with the risk of development and progression of various cancers are well studied, mainly in middle-aged and elderly subjects. In this article, we have revised the evidence on the effects of physical activity on the expression and release of the adipose-tissue-derived mediators of low-grade chronic inflammation, i.e., adipokines, as well as the adipokine-mediated impacts of physical activity on tumor development, growth, and metastasis. Importantly, exercise training may be effective in mitigating the side effects related to anti-cancer treatment, thereby underlining the importance of encouraging cancer patients to engage in moderate-intensity activities. However, the strong need to customize and adapt exercises to a patient’s abilities is apparent. Besides the preventive effects of physically active behavior against the adipokine-stimulated cancer risk, it remains poorly understood how physical activity, through its actions as an adipokine, can actually influence the onset and development of metastases.

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Section: Effects Of Physical Activity On Adipose Tissue Low-grade Inflammation and Tumor Progressionmentioning

confidence: 99%

Another Weapon against Cancer and Metastasis: Physical-Activity-Dependent Effects on Adiposity and Adipokines

Perego

Sansoni

Ziemann³

et al. 2021

IJMS

View full text Add to dashboard Cite

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Diet and Cancer Prevention Research: From Mechanism to Implementation

Lampe

2020

J Cancer Prev

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Between 30% to 50% of cancer cases are estimated to be preventable through reduced exposure to tobacco, occupational carcinogens, and infectious agents, and adoption of lifelong healthy eating and a physically active lifestyle. In the past, diet and cancer prevention research has aimed to understand the effects of specific foods and nutrients on cancer-related mechanisms. More recently, there has been a shift in emphasis toward a more holistic focus on patterns of diet, reflecting the goal to understand the impact of adhering to broader public health recommendations. It is increasingly apparent from observational studies that different patterns of diet and physical activity are manifest in a metabolic state that is more, or less, conducive to the acquisition of genetic and epigenetic alterations leading to carcinogenesis. Experimental studies in cell systems, animals and humans have expanded our understanding of the many mechanisms by which specific dietary constituents may modulate inflammation and immune function, carcinogen metabolism, hormone and growth-factor regulation, DNA repair capacity, cell-cycle control, and proliferation and apoptosis. However, few mechanistic studies in animal models have evaluated diets containing the complex mixtures that make up human diets. Overall, more studies are needed across the continuum of prevention research, from basic mechanistic research on the effects of diet patterns on fundamental biologic processes to studies testing the efficacy of implementing lifestyle-directed cancer prevention strategies.

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Anticancer potential of garlic bioactive constituents: Allicin, Z-ajoene, and organosulfur compounds

Talib,

Atawneh,

Shakhatreh

et al. 2024

PHAR

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Cancer, a formidable disease with a significant mortality rate, continues to claim the lives of thousands of individuals annually in contemporary society. Conventional cancer therapies are notorious for their substantial adverse effects and lack of specificity. Within the context of neoplastic development, cancer hallmarks represent fundamental biological properties that cancer cells progressively acquire. A promising approach for combating cancer involves the simultaneous targeting of multiple cancer hallmarks. Plant-derived natural compounds stand out as a promising reservoir for the development of novel and more efficacious anticancer therapeutics due to their structural diversity and minimal toxicity profiles. Garlic (Allium sativum) has garnered considerable attention for its established anti-cancer properties over the years. Within garlic, a myriad of bioactive constituents, including organosulfur compounds, flavonoids, and phenolic compounds, exhibit distinct effects on cancer cells. The objective of this review paper is to furnish a comprehensive elucidation of the mechanisms underpinning the anticancer actions of garlic. The elucidated findings from the studies encompassed within this review not only contribute to a more profound comprehension of the anti-cancer properties of garlic but also serve as a robust foundation upon which researchers and healthcare practitioners can formulate enhanced anticancer pharmaceuticals grounded in natural garlic compounds.

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Impact of Diet and Nutrition on Cancer Hallmarks

Cited by 3 publications

References 142 publications

Another Weapon against Cancer and Metastasis: Physical-Activity-Dependent Effects on Adiposity and Adipokines

Another Weapon against Cancer and Metastasis: Physical-Activity-Dependent Effects on Adiposity and Adipokines

Diet and Cancer Prevention Research: From Mechanism to Implementation

Anticancer potential of garlic bioactive constituents: Allicin, Z-ajoene, and organosulfur compounds

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Impact of Diet and Nutrition on Cancer Hallmarks

Cited by 3 publications

References 142 publications

Another Weapon against Cancer and Metastasis: Physical-Activity-Dependent Effects on Adiposity and Adipokines

Another Weapon against Cancer and Metastasis: Physical-Activity-Dependent Effects on Adiposity and Adipokines

Diet and Cancer Prevention Research: From Mechanism to Implementation

﻿Anticancer potential of garlic bioactive constituents: Allicin, Z-ajoene, and organosulfur compounds

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Anticancer potential of garlic bioactive constituents: Allicin, Z-ajoene, and organosulfur compounds