Impact of Diastolic Dysfunction Grade on Left Atrial Mechanics Assessed by Two-Dimensional Speckle Tracking Echocardiography

Otani, Kyoko; Takeuchi, Masaaki; Kaku, Kyoko; Haruki, Nobuhiko; Yoshitani, Hidetoshi; Tamura, Masahito; Abe, Haruhiko; Okazaki, Masahiro; Ota, Toshiyuki; Lang, Roberto M.; Otsuji, Yutaka

doi:10.1016/j.echo.2010.06.023

Cited by 71 publications

(69 citation statements)

References 26 publications

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“…In that study, LAV min and LAV max both increased with worsening LV diastolic function, but the analyses were not adjusted for confounders, and no direct comparison between LA volumes was performed 21. Similar results were shown in another study using speckle-tracking derived LA volumes 23. LA phasic volumes have also been found dilated in patients with diastolic heart failure24 and untreated hypertension25 compared with controls.…”

Section: Discussionmentioning

confidence: 58%

Left atrial minimum volume and reservoir function as correlates of left ventricular diastolic function: impact of left ventricular systolic function

Russo

Jin

Homma

et al. 2012

Heart

189

141

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Objective Left atrial (LA) maximum volume (LAVmax) is an indicator of left ventricular (LV) diastolic function. However, LAVmax is also influenced by systolic events, whereas the LA minimum volume (LAVmin) is directly exposed to LV pressure. The authors hypothesised that LAVmin may be a better correlate of LV diastolic function than LAVmax. Design Cross-sectional. Setting University hospital. Patients 357 participants from a community-based cohort study. Methods LA volumes and reservoir function, measured as total LA emptying volume (LAEV) and LA emptying fraction (LAEF), were assessed by real-time three-dimensional echocardiography. LV diastolic function was assessed by trans-mitral early (E) and late (A) Doppler velocities and mitral early diastolic velocity by tissue-Doppler (e′). LV systolic function was assessed by LV ejection fraction (LVEF) and global longitudinal strain (GLS) by speckle-tracking. Results LAVmin significantly increased with worsening diastolic dysfunction (p<0.001), whereas the increase in LAVmax was less pronounced (p=0.07). LAEV and LAEF decreased with worsening diastolic dysfunction (both p<0.001). In linear regressions, LAVmin and LAVmax were significant predictors of E/e′, with higher parameter estimates for LAVmin. In multivariate models, LAVmin resulted strongly associated with E/e′ (β=0.45, p<0.001), whereas LAVmax was not (β=− 0.16, p=0.08). LA reservoir function was better associated with GLS than LVEF. In multivariate analyses, GLS was significantly associated with LAVmax (β=− 0.15, p=0.002), LAEV (β=−0.37, p<0.001) and LAEF (β=−0.28, p<0.001) but not with LAVmin. Conclusions LAVmin is a better correlate of LV diastolic function than LAVmax. The impact of LV longitudinal systolic function on LA reservoir function might explain the weaker relation between LAVmax and LV diastolic function.

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Section: Discussionmentioning

confidence: 58%

Left atrial minimum volume and reservoir function as correlates of left ventricular diastolic function: impact of left ventricular systolic function

Russo

Jin

Homma

et al. 2012

Heart

189

141

View full text Add to dashboard Cite

show abstract

“…Apart from differences related to imaging techniques, these discrepancies might be related to a biphasic evolution of LV booster pump function with advancing diastolic dysfunction, mirroring the progression of the transmitral profile. As suggested by Otani et al [24], there might be a compensatory augmentation of the LA booster pump function in patients with mild and moderate diastolic dysfunction, but a significant reduction in presence of severe diastolic dysfunction. In our study population of patients with LV hypertrophy and increased stiffness index, LA myocardial fibrosis might have precluded the compensatory augmentation of active LA contraction.…”

Section: Discussionmentioning

confidence: 94%

“…As an index of early diastole, E/E 0 is affected by LV relaxation abnormalities and by increased filling pressures. Otani et al [24] suggested a progressive decline of LA conduit function with advanced stages of diastolic dysfunction.…”

Section: Discussionmentioning

confidence: 98%

Hypertensive patients with left ventricular hypertrophy have global left atrial dysfunction and impaired atrio-ventricular coupling

Soullier

Niamkey

Ricci

et al. 2016

Journal of Hypertension

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“…LA remodeling disrupts the Ca transfer and stimulation of the fibrils in the left atrial tissue and may lead to a decrease in LA contraction. In addition, myocardial damage and fibrosis accompanying LA remodeling may also negatively affect the active and passive movements of LA [27]. The changes in the structure of LA may result in disruption in the conduit and pump functions in addition to the reservoir functions in the severe OSA group.…”

Section: Discussionmentioning

confidence: 96%

Assessment of left atrial dysfunction in obstructive sleep apnea patients with the two dimensional speckle-tracking echocardiography

et al. 2012

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Impact of Diastolic Dysfunction Grade on Left Atrial Mechanics Assessed by Two-Dimensional Speckle Tracking Echocardiography

Cited by 71 publications

References 26 publications

Left atrial minimum volume and reservoir function as correlates of left ventricular diastolic function: impact of left ventricular systolic function

Left atrial minimum volume and reservoir function as correlates of left ventricular diastolic function: impact of left ventricular systolic function

Hypertensive patients with left ventricular hypertrophy have global left atrial dysfunction and impaired atrio-ventricular coupling

Assessment of left atrial dysfunction in obstructive sleep apnea patients with the two dimensional speckle-tracking echocardiography

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