Impact of diabetes mellitus on treatment outcome of newly diagnosed smear-positive pulmonary tuberculosis patients: A case–Control study

Subhankar, Saswat; Rout, Pragyan Paramita; Jagaty, SumanKumar; Behera, Debasis; Mohapatra, SangramKeshari; Panda, Gitanjali

doi:10.4103/mjdrdypu.mjdrdypu_911_21

Cited by 1 publication

(1 citation statement)

References 7 publications

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“…Out of 49 studies included in this meta-analysis, nine studies were from India [ 24 , 27 , 30 , 32 , 36 , 44 , 47 , 57 , 58 ], four from South Korea [ 1 , 29 , 31 , 49 ], three from Taiwan [ 7 , 23 , 40 ], two from Ethiopia [ 2 , 50 ], four from Mexico [ 28 , 34 , 42 , 43 ], six from China [ 17 , 51 , 52 , 54–56 ], one from Thailand [ 25 ], two from Malaysia [ 46 , 62 ], two from Nigeria [ 35 , 59 ], two from Brazil [ 37 , 45 ], two from Georgia [ 38 , 41 ] and one each from Indonesia [ 26 ], Canada [ 33 ], Pakistan [ 39 ], London [ 61 ], Armenia [ 48 ], Nepal [ 53 ] and Albania [ 60 ]. Among these, the study design of 23 studies was retrospective cohort, 19 studies were prospective, one study was a cross-sectional study and one study was a case-control study.…”

Section: Resultsmentioning

confidence: 99%

Tuberculosis (TB) treatment challenges in TB-diabetes comorbid patients: a systematic review and meta-analysis

Khattak,

Rehman,

Muqaddas

et al. 2024

Annals of Medicine

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Background The Directly Observed Treatment-Short Course (DOTS) Programme was implemented by WHO and includes a combination of four anti-tuberculosis (TB) drugs (isoniazid, pyrazinamide, ethambutol and rifampicin) for a period of six months to eradicate the TB infection completely. Diabetes mellitus (DM) is recognized as one of a strong contributor of TB according to World Health Organization (WHO). The presence of diabetes mellitus type 2 (DM type 2) makes TB treatment complicated. Thus, the objective of the current meta-analysis was to identify and quantify the impact of type 2 DM on treatment outcomes of TB patients treated under the DOTS Programme. Methods This meta-analysis was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Through a systematic review of relevant literature, we focused on studies investigating treatment outcomes including extended treatment duration and recurrence for individuals with both TB and DM undergoing DOTS therapy. The extracted information included study designs, sample sizes, patient characteristics and reported treatment results. Results In 44 studies from different parts of the world, the pooled HR for the impact of DM on extended treatment duration and reoccurrence were HR 0.72, 95% CI 0.56–0.83, p < .01 and HR 0.93, 95% CI 0.70–1.04, p = .08, respectively. The pooled HR for impact of DM on composite TB treatment outcomes was calculated as 0.76 (95% CI 0.60–0.87), p < .01 with an effect size of 41.18. The heterogeneity observed among the included studies was moderate ( I 2 = 55.79%). Conclusions A negative impact of DM was found on recurrence and extended treatment duration in TB patients treated with DOTS therapy. DM type 2 is responsible for the TB treatment prolongation and TB recurrence rates. By implementing effective management strategies and advancing research, the challenges can be mitigated, arising due to the complex interaction between DM and TB.

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