Impact of diabetes mellitus on the contractile properties of the left and right atrial myofilaments†

Bening, C.; Alhussini, K.; Mazalu, E.; Yaqub, Jonathan; Hamouda, K.; Radakovic, D.; Schimmer, Christoph; Hirnle, Grzegorz; Leyh, Rainer

doi:10.1093/ejcts/ezy154

Cited by 6 publications

(9 citation statements)

References 25 publications

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“…18, 19, 20, 21). Our previous study demonstrated that there is a signi cant force decrease in right auricular myo laments in patients with type 2 diabetes compared without (9). Similarly, Patschneider et al showed that DM as well as prediabetes is associated with decreased RV endsystolic and enddiastolic volumes as well as stroke volumes, indicative of early-onset RV impairment prior to symptom onset.…”

Section: Discussionmentioning

confidence: 74%

“…Posttranslational modi cation (O-linked ß-N-acetylglucosamine modi cation) in DM patients may have contributed to changes in calcium sensitivity, which is a measure of impaired contractile force development. (9).…”

Section: Discussionmentioning

confidence: 99%

“…We measured the calcium-induced force of right atrial skinned human bers as previously described (8,9,10). We resected the RAA for venous cannulation of extracorporal circulation.…”

Section: Experimental Set-upmentioning

confidence: 99%

“…For the skinning procedure, the trabeculae were excised, immersed in Triton-X solution (Sigma Aldrich Chemie GmbH, Steinheim, Germany) and processed for sarcolemma removal The trabeculae were then cut in to small bundles for the experimental cycle. The experimental set-up has been previously described (8,9,10). Brie y, the bundles were xed between two forceps.…”

Section: Experimental Set-upmentioning

confidence: 99%

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Clinically Inapparent Right Heart Dysfunction is Associated with Reduced Myofilament Force Development in Coronary Artery Disease

Bening

Sales

Alhussini

et al. 2020

Preprint

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Background: Right ventricular dysfunction after CABG is associated with poor peri- and postoperative outcomes. We hypothesized that inapparent RV dysfunction in these patients is already associated with pathological changes at the level of myofilaments in concert with altered biomarkers of myocardial remodeling and endothelial dysfunction.Methods: From 08/2016 to 02/2018, 218 patients scheduled for CABG were divided into two groups (TAPSE ≥20mm, n=178;TAPSE<20mm,n=40). Baseline serum samples for biomarkers (Galectin,TGFß1,N Acyl-SDMA, Arginine, ADMA and Pentraxin-3), clinical laboratory and transthoracic echocardiographic parameters were evaluated. To examine the myocardial apparatus of the right ventricle intraoperative right auricular tissue was harvested for stepwise skinned fiber force measurements.Results: Patients with TAPSE <20mm had a higher incidence of DM (55vs34%,p=0.018), preoperative AFib (43vs16%,p=0.000), reduced GFR (67±18vs77±24 ml/min/1.73m2,p=0.013), larger LA area (22±6vs20±5cm2,p=0.005) and reduced LVEF (50vs55 %,p=0.008). Furthermore, higher serum ADMA (0.70±0.13vs0.65±0.15µmol/l, p=0.046) and higher serum Pentraxin-3 levels (3371±1068vs2681±1353pg/dl,p=0.004) were observed in these Patients. Skinned fibre force measurements showed significant lower values at almost every step of calcium concentration (pCa 4.52 to pCa 5.5,p<0.01 and pCa 5.75 to 6.0,p< 0.05). Multivariable analysis revealed DM (OR 2.53 CI1.12-5.73, Euro Score II (OR1.34 CI 1.02-1.78), preoperative AF (OR4.86 CI2.06-11.47), GFR (OR7.72 CI 1.87-31.96), albumin (OR1.56 CI 0.52-2.60), Pentraxin-3 (OR19.68 CI14.13-25.24), depressed LVEF (OR8.61 CI 6.37-10.86), lower force values: (pCa 5.4; OR2.34 CI 0.40-4.29 and pCa 5.2; OR2.00 CI 0.39-3.60) as predictors for clinical inapparent right heart dysfunction. Conclusions: These preliminary data showed that inapparent right heart dysfunction in CAD is already associated with reduced force development of the contractile apparatus.

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Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 99%

“…We measured the calcium-induced force of right atrial skinned human bers as previously described (8,9,10). We resected the RAA for venous cannulation of extracorporal circulation.…”

Section: Experimental Set-upmentioning

confidence: 99%

Section: Experimental Set-upmentioning

confidence: 99%

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Clinically Inapparent Right Heart Dysfunction is Associated with Reduced Myofilament Force Development in Coronary Artery Disease

Bening

Sales

Alhussini

et al. 2020

Preprint

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“…LV diastolic and systolic dysfunction caused by T2DM may have an important in uence on RV due to the ventricular interdependence. The two ventricles are combined anatomically through their muscle ber anatomical structure and IVS, exhibiting an interdependent physiological feature, [23] which is related to the interwoven subendocardial bers of IVS between RV and LV, indicating that diabetes inducing myocardial diffuse brosis can affect eccentric hypertrophy, diastolic and systolic dysfunction of the two ventricles. Due to the non-antagonistic vasoconstriction by T2DM, [22] systemic macrovascular and microvascular functions were impaired and the arterial tension was increased by causing myocardial endothelial cell dysfunction, in ammatory response, calcium homeostasis change and substrate metabolism.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Cardiac Functions By Speckle Tracking Echocardiography in Type 2 Diabetes Mellitus With Hyperlipidemia

Dong

Zhou

Chen

et al. 2021

Preprint

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Background To investigate the value of two-dimensional speckle tracking echocardiography (2D-STE) in evaluating cardiac functions in type 2 diabetes mellitus (T2DM) with hyperlipidemia. Methods Sixty T2DM patients with normal left ventricular ejection fraction (LVEF) and poorly-controlled blood glucose were selected. Among these, thirty had hyperlipidemia. Thirty age- and gender-matched healthy individuals were recruited as the normal control group. Longitudinal strain of left ventricular segments, left ventricular global longitudinal strain (LV GLS), left atrial global longitudinal strain (LA GLS), right ventricular global longitudinal strain (RV GLS) and right atrial global longitudinal strain (RA GLS) were measured by 2D-STE. Results (1) Compared with the normal control group, LV GLS in T2DM group and T2DM with hyperlipidemia group decreased (P < 0.05), but there was no significant difference of LV GLS between T2DM group and T2DM with hyperlipidemia group (P > 0.05). Compared with the normal control group and T2DM group, longitudinal strain of middle segment of LV in T2DM with hyperlipidemia group decreased (P < 0.05). (2) There was a significant difference in LA GLS among the three groups. LA GLS of T2DM with hyperlipidemia group was lower compared with the normal control and T2DM group (P < 0.05). (3) Compared with the normal control group, RV GLS in T2DM group and T2DM with hyperlipidemia group was lower (P < 0.05), but there was no significant difference of RV GLS between T2DM group and T2DM with hyperlipidemia group (P > 0.05). RA GLS in T2DM with hyperlipidemia group decreased (P < 0.05) compared to the normal control group and T2DM group. Conclusion Speckle tracking echocardiography can effectively evaluate cardiac dysfunction in patients with T2DM. LA GLS and RA GLS can be used as potential markers of cardiac dysfunction in T2DM with hyperlipidemia, and provide the basis for early clinical diagnosis and treatment.

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Ca2+ mishandling and mitochondrial dysfunction: a converging road to prediabetic and diabetic cardiomyopathy

Giusti

Palomeque

Mattiazzi

2022

Pflugers Arch - Eur J Physiol

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Diabetic cardiomyopathy is defined as the myocardial dysfunction that suffers patients with diabetes mellitus (DM) in the absence of hypertension and structural heart diseases such as valvular or coronary artery dysfunctions. Since the impact of DM on cardiac function is rather silent and slow, early stages of diabetic cardiomyopathy, known as prediabetes, are poorly recognized, and, on many occasions, cardiac illness is diagnosed only after a severe degree of dysfunction was reached. Therefore, exploration and recognition of the initial pathophysiological mechanisms that lead to cardiac dysfunction in diabetic cardiomyopathy are of vital importance for an on-time diagnosis and treatment of the malady. Among the complex and intricate mechanisms involved in diabetic cardiomyopathy, Ca 2+ mishandling and mitochondrial dysfunction have been described as pivotal early processes. In the present review, we will focus on these two processes and the molecular pathway that relates these two alterations to the earlier stages and the development of diabetic cardiomyopathy. Supplementary Information The online version contains supplementary material available at 10.1007/s00424-021-02650-y.

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Impact of diabetes mellitus on the contractile properties of the left and right atrial myofilaments†

Abstract: We demonstrated that diabetes mellitus has a significantly negative impact on calcium-induced force development in left and right atrial myofilaments.

Cited by 6 publications

References 25 publications

Clinically Inapparent Right Heart Dysfunction is Associated with Reduced Myofilament Force Development in Coronary Artery Disease

Clinically Inapparent Right Heart Dysfunction is Associated with Reduced Myofilament Force Development in Coronary Artery Disease

Evaluation of Cardiac Functions By Speckle Tracking Echocardiography in Type 2 Diabetes Mellitus With Hyperlipidemia

Ca2+ mishandling and mitochondrial dysfunction: a converging road to prediabetic and diabetic cardiomyopathy

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