Impact of Diabetes Mellitus on the Immunity of Tuberculosis Patients: A Retrospective, Cross-Sectional Study

Wei, Ruda; Li, Pengchuan; Xue, Yong; Liu, Yinping; Gong, Wenping; Zhao, Weiguo

doi:10.2147/rmhp.s354377

Cited by 19 publications

(27 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, TNF- α , as mentioned above, was increased in the OP group, which is probably due to the secretion of TNF- α by other immune cells. Immune cells in the body will differentiate and produce different types of cytokines under the influence of various factors and mediate infectious or noninfectious diseases [ 37 ]. We will further explore the reasons for the increase in TNF- α in the senile OP population in future mechanistic studies.…”

Section: Discussionmentioning

confidence: 99%

Effect of Lymphocyte Subsets on Bone Density in Senile Osteoporosis: A Retrospective Study

Peng

Guo

Zhao

et al. 2022

Journal of Immunology Research

Self Cite

View full text Add to dashboard Cite

Background. Several studies have shown that lymphocyte subsets can mediate the occurrence of osteoporosis (OP); however, the predictive ability of lymphocyte subsets in senile OP has not been elucidated. Purpose. To investigate the ability of lymphocyte subsets to predict senile osteoporosis (OP). Methods and Materials. This study included 44 patients with senile OP and 44 without OP. Dual-energy X-ray absorptiometry (DEXA) was used to determine bone mineral density (BMD). Flow cytometry was used to analyze the absolute counts of the lymphocyte subsets and cytokine levels. Finally, the correlation between BMD and lymphocyte subset counts in the two groups was analyzed. Results. There were no significant differences in age, sex, or weight between the OP and non-OP groups. The absolute counts of total T lymphocytes and CD8+ T lymphocytes in the OP group were significantly lower than those in the non-OP group. The levels of IFN-γ or TNF-α in the OP group were significantly higher or lower, respectively, than those in the non-OP group. PCA showed that age, BMI, total T lymphocytes, CD4+ T lymphocytes, CD8+ T lymphocytes, and B lymphocytes were the principal components of senile OP. The linear regression equation showed that BMD of the right femoral neck significantly decreased with a decline in CD8+ T lymphocyte counts. Conclusion. BMD decreased with a decrease in CD8+ T lymphocytes. The mechanism by which lower lymphocyte subsets lead to lower BMD may be related to abnormal bone metabolism caused by immune aging. Therefore, we considered that CD8+ T lymphocytes could be used to predict the incidence of senile OP.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of Lymphocyte Subsets on Bone Density in Senile Osteoporosis: A Retrospective Study

Peng

Guo

Zhao

et al. 2022

Journal of Immunology Research

Self Cite

View full text Add to dashboard Cite

show abstract

“…Before initialing TPT, identifying LTBI accurately was one of the challenges faced as current available LTBI diagnostic tools were based on the immune response. Previous studies have found that poor glycemic control may lead to a blunted immune response ( 12 , 13 ). Neutrophil chemotaxis and oxidative killing potential were reduced in DM patients compared to nondiabetic controls, and leukocyte bactericidal activity was reduced, especially in patients with poor glycemic control ( 2 ).…”

Section: Discussionmentioning

confidence: 99%

“…It indicated participants with C-TST conversion in the baseline IGRA-negative group are more inclined to the true LTBI status. T2DM patients may have a false-negative TST or C-TST due to immunosuppression ( 12 , 33 ). However, the use of the booster effect to increase the detection of LTBI had been recommended in different populations, including immunosuppressed patients as well as healthy population ( 34 – 36 ).…”

Section: Discussionmentioning

confidence: 99%

“…C-TST had not been systematically evaluated in various populations, and along with IGRA and TST, all the three detection methods are based on immunological response. Due to T2DM can impair host immune function ( 12 , 13 ), whether the performance of TST, IGRA and C-TST would be influenced in T2DM patients had been rarely studied. The current study detected the prevalence of LTBI in registered T2DM patients from rural China using three assays in parallel twice (baseline and 3 months later), aiming to evaluate the performance of IGRA, TST and C-TST in serial testing among T2DM patients.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Serial testing of latent tuberculosis infection in patients with diabetes mellitus using interferon-gamma release assay, tuberculin skin test, and creation tuberculin skin test

Cao

Guo

et al. 2022

Front. Public Health

View full text Add to dashboard Cite

BackgroundDiabetes mellitus (DM) patients with latent tuberculosis infection (LTBI) have an increased risk of developing active tuberculosis (TB) due to impaired immunity. The performance of currently available immune response-based assays for identification of TB infection had been rarely evaluated in patients with type 2 DM (T2DM) in China.MethodsA prospective study was conducted to investigate the status of LTBI in patients with confirmed T2DM. At the baseline survey, the prevalence of LTBI was tested using interferon-gamma release assay (IGRA), tuberculin skin test (TST) and creation tuberculin skin test (C-TST) in parallel. After a 3-month interval, the participants were retested by the three assays to estimate their performance in the serial testing.ResultsA total of 404 participants with T2DM were included in the study. At baseline, after excluding active TB, the prevalence of LTBI identified by TST (≥ 10 mm), C-TST (≥ 5 mm) and IGRA (≥ 0.35 IU/ml) were 9.65% (39/404), 10.40% (42/404) and 14.85% (60/404), respectively. The concordance of TST and C-TST results with IGRA results was 86.39% (349/404) and 92.08% (372/404) with a Kappa coefficient of 0.37 [95% confidence interval (CI): 0.24– 0.50] and 0.64 (95% CI: 0.53– 0.76), respectively. After a 3-month interval, the continuous results of TST, C-TST and IGRA were observed to be increased with testing conversion for 50, 26 and 27 patients, respectively. For TST and C-TST conversions, the distribution of their quantitative results in serial tests varied significantly when further classified by baseline IGRA dichotomous results.ConclusionIn studied patients with T2DM, C-TST showed higher consistency with IGRA as compared to TST. The present of conversion observed in serial testing suggested that boosting effect of skin testing should be considered for identify of LTBI in patients with T2DM.

show abstract

“…IFN-y level is negatively correlated with HbA1c glycated hemoglobin levels. Poorly treated diabetes also increases the severity of tuberculosis [24,25].…”

Section: Tuberculosis Risk Factors Over the Centuriesmentioning

confidence: 99%

Prevention and treatment of tuberculosis before two great discoveries of the 20th century: the Bacillus Calmette-Guérin vaccine and streptomycin

Adamowicz,

Łopuszyńska,

Zembala

et al. 2023

J Educ Health Sport

View full text Add to dashboard Cite

Introduction and Purpose. Fundamental milestone in fight against tuberculosis is the invention of the effective vaccine, but before Anthony van Leeuwenhoek was the first to observe the bacteria, which opened the door to the first vaccinations in the 19th century. Medicine had battled against infectious diseases in different ways. Some methods can be perceived as a kind of primitive vaccines, which couldn’t, however, considerably affect a decrease in the epidemic range, due to their uncommon use and limited effectiveness. The aim of this paper is to analyze the history of tuberculosis and the role of Poland in the fight against it. Materials and methods. PubMed database was used for review of the literature. The following phrases were searched in English: “tuberculosis”, “vaccination”, “BCG vaccine”, “sanatorium”. Description of the state of knowledge. Poland played an important role in the fight against tuberculosis. It was in the laboratory of Polish pharmacist, where Koch discovered its etiological factor. In the territory of Poland there are prototypes of modern sanatoria for tuberculosis patients. Article also presents old and modern methods of tuberculosis treatment, as the use of specific climatic conditions, which resulted in developing health-resort treatment. A breakthrough in the methods used was the discovery of streptomycin in the middle of the 20th century, which led to the development of pharmacological treatment, nowadays involving the administration of proper combinations of drugs. Summary. The increasingly strong anti-vaccine movement is slowly destroying what people have been fighting for the centuries. It is worth recalling how we reached milestones in this fight and why immunization is so important for all societies.

show abstract

Impact of Diabetes Mellitus on the Immunity of Tuberculosis Patients: A Retrospective, Cross-Sectional Study

Cited by 19 publications

References 43 publications

Effect of Lymphocyte Subsets on Bone Density in Senile Osteoporosis: A Retrospective Study

Effect of Lymphocyte Subsets on Bone Density in Senile Osteoporosis: A Retrospective Study

Serial testing of latent tuberculosis infection in patients with diabetes mellitus using interferon-gamma release assay, tuberculin skin test, and creation tuberculin skin test

Prevention and treatment of tuberculosis before two great discoveries of the 20th century: the Bacillus Calmette-Guérin vaccine and streptomycin

Contact Info

Product

Resources

About