2013
DOI: 10.1371/journal.pone.0058044
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Impact of Diabetes and Smoking on Mortality in Tuberculosis

Abstract: BackgroundDiabetes mellitus is a risk factor for tuberculosis (TB) disease. There is evidence that diabetes also influences TB severity and treatment outcomes but information is incomplete and some published results have been inconsistent.MethodsA longitudinal cohort study was conducted at the National Masan Tuberculosis Hospital in the Republic of Korea. Subjects presenting with a first episode of TB or for retreatment of TB were followed from enrollment through completion of treatment. Demographic, clinical,… Show more

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Cited by 79 publications
(93 citation statements)
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“…The prevalence of DM and smoking was higher among the younger age groups. 3 It has been recommended that TB patients should be routinely screened for both of these risk factors and that, if present, they should be addressed to improve TB treatment outcomes. 3 India, with an annual incidence of 2.2 million TB cases, has the highest TB burden in the world.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…The prevalence of DM and smoking was higher among the younger age groups. 3 It has been recommended that TB patients should be routinely screened for both of these risk factors and that, if present, they should be addressed to improve TB treatment outcomes. 3 India, with an annual incidence of 2.2 million TB cases, has the highest TB burden in the world.…”
Section: Resultsmentioning
confidence: 99%
“…3 It has been recommended that TB patients should be routinely screened for both of these risk factors and that, if present, they should be addressed to improve TB treatment outcomes. 3 India, with an annual incidence of 2.2 million TB cases, has the highest TB burden in the world. 4 Nearly 63 million people (∼8% of the adult population aged ⩾20 years) are estimated to have DM, and 120 million are estimated to be tobacco smokers (∼14% of the adult population).…”
Section: Resultsmentioning
confidence: 99%
“…A major difference in mean age was observed between ex-smokers and current smokers. The high mortality rate among ex-smokers probably reflected the combined effects of smoking [7][8][9][10] and age-related comorbidities [25,26]. It also remained a possibility that some of these comorbidities could have promoted the motivation for smoking cessation in the first place, and then increased the higher mortality on later follow-up.…”
Section: Discussionmentioning
confidence: 99%
“…[36] The relationship between DM and other co-factors that enhance TB risk are emerging (e.g. DM plus smoking) and are likely to become a common theme as additional studies are conducted [37]. …”
Section: Impact Of Dm On Progression To Tbmentioning
confidence: 99%