Impact of diabetes and metformin use on prostate cancer

Taussky, Daniel; Delouya, Guila

doi:10.1080/21681805.2020.1806355

Cited by 3 publications

(3 citation statements)

References 8 publications

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“…The effect of metformin in patients treated with radiotherapy is promising, with some studies showing an association with improved outcomes, with up to a 50% reduction in biochemical relapse. 131–133 However others found no significant difference with metformin use. 134,135 In contrast, seven studies of metformin use amongst men treated with radical prostatectomy all found no association with risk of biochemical relapse.…”

Section: Therapeutic Targeting Of Aberrant Lipid Metabolismmentioning

confidence: 99%

Targeting lipid metabolism in metastatic prostate cancer

et al. 2023

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Despite key advances in the treatment of prostate cancer (PCa), a proportion of men have de novo resistance, and all will develop resistance to current therapeutics over time. Aberrant lipid metabolism has long been associated with prostate carcinogenesis and progression, but more recently there has been an explosion of preclinical and clinical data which is informing new clinical trials. This review explores the epidemiological links between obesity and metabolic syndrome and PCa, the evidence for altered circulating lipids in PCa and their potential role as biomarkers, as well as novel therapeutic strategies for targeting lipids in men with PCa, including therapies widely used in cardiovascular disease such as statins, metformin and lifestyle modification, as well as novel targeted agents such as sphingosine kinase inhibitors, DES1 inhibitors and agents targeting FASN and beta oxidation.

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Section: Therapeutic Targeting Of Aberrant Lipid Metabolismmentioning

confidence: 99%

Targeting lipid metabolism in metastatic prostate cancer

et al. 2023

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“…Metformin, an antidiabetic drug from several studies, has been proved to not only effect on glucose metabolism but also show interactions with androgen receptors. It plays a role in stabilizing prostate specific antigen (PSA) levels[ 42 ]. In certain therapy, another commonly used method for T2DM, it is reported that glucagon-like peptide-1 receptor expression plays an anti-prostate cancer effect.…”

Section: Prostate Cancer and Diabetes Linco1128mentioning

confidence: 99%

Diabetes mellitus susceptibility with varied diseased phenotypes and its comparison with phenome interactome networks

Rout¹,

Kour²,

Vuree³

et al. 2022

WJCC

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An emerging area of interest in understanding disease phenotypes is systems genomics. Complex diseases such as diabetes have played an important role towards understanding the susceptible genes and mutations. A wide number of methods have been employed and strategies such as polygenic risk score and allele frequencies have been useful, but understanding the candidate genes harboring those mutations is an unmet goal. In this perspective, using systems genomic approaches, we highlight the application of phenome-interactome networks in diabetes and provide deep insights. LINC01128, which we previously described as candidate for diabetes, is shown as an example to discuss the approach.

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“…Overall mortality was higher in diabetics but there was no difference in prostate-specific survival between non-diabetic patients compared to metformin users or metformin non-users. [7] Concerning metformin users, prostate cancer-specific mortality risk was insignificantly lower in diabetic men on metformin (HR 0.74, 95% CI 0.54-1.02, p ¼ 0.07) compared to non-diabetics. Diabetic non-metformin users had a slightly non-significant decreased prostate-cancer specific survival.…”

mentioning

confidence: 92%

Metformin and Prostate Cancer

2024

J Urol Ren Dis

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Impact of diabetes and metformin use on prostate cancer

Cited by 3 publications

References 8 publications

Targeting lipid metabolism in metastatic prostate cancer

Targeting lipid metabolism in metastatic prostate cancer

Diabetes mellitus susceptibility with varied diseased phenotypes and its comparison with phenome interactome networks

Metformin and Prostate Cancer

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