Impact of di-n-butyl phthalate on reproductive system development in European pikeperch (Sander lucioperca)

Jarmołowicz, Sylwia; Demska‐Zakęś, Krystyna; Zakęś, Zdzisław

doi:10.2754/avb201382020197

Cited by 9 publications

(6 citation statements)

References 16 publications

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“…Similar results were obtained in the present study, where exposure to either of the 2 EE2‐only treatments from 20 dpf to 115 dpf completely feminized all fish. To our knowledge, the effects of DBP on sex ratio in fish have not been reported before, apart from Jarmołowicz et al , who detected a decreased percentage of males in European pikeperch ( Sander lucioperca ) exposed to the highest analyzed dose of 2 g DBP/kg feed. However, the sex ratio in DBP‐only treatments was not significantly different from the solvent control in the present study.…”

Section: Discussionmentioning

confidence: 74%

“…apart from Jarmołowicz et al [10], who detected a decreased percentage of males in European pikeperch (Sander lucioperca) exposed to the highest analyzed dose of 2 g DBP/kg feed. However, the sex ratio in DBP-only treatments was not significantly different from the solvent control in the present study.…”

mentioning

confidence: 88%

“…We selected 17α‐ethinyl estradiol (EE2) and dibutyl phthalate (DBP) as representative of xenoestrogens and phthalate esters, respectively. Both chemicals are known to affect the growth, development, gonadal differentiation, and reproduction of aquatic organisms . They can be detected concurrently in aquatic environments and often are assumed to have the potential to accumulate in biological organisms because of their lipophilicity .…”

Section: Introductionmentioning

confidence: 99%

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Long‐term effects of binary mixtures of 17α‐ethinyl estradiol and dibutyl phthalate in a partial life‐cycle test with zebrafish (Danio rerio)

Chen

Liu

et al. 2015

Enviro Toxic and Chemistry

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Using 17α-ethinyl estradiol (EE2) and dibutyl phthalate (DBP) as a typical estrogen and phthalate ester, respectively, their combined in vivo effects on zebrafish (Danio rerio) were investigated from the juvenile state to the adult stage. The authors spiked EE2 (5 ng/L and 20 ng/L) and DBP (0.1 mg/L and 0.5 mg/L) either individually or in mixture. At 45 d postfertilization (dpf), the survival rate of zebrafish was comparable in all treatments. Dibutyl phthalate did not induce vitellogenin (VTG) synthesis, and no interaction was found between EE2 and DBP on VTG induction. At 90 dpf, both liver and gill were subject to more severe damage (lipid vacuoles of hepatocytes, amalgamation of gill lamellae, and clubbing at the tips of the secondary lamellae) when coexposed to these 2 chemicals, compared with single exposure. At 115 dpf, generally none of the binary mixture groups showed significantly different growth and sex ratios compared with the corresponding EE2 alone groups. In conclusion, no obvious interactions were detected between EE2 and DBP on the growth, VTG induction, or sex ratio of zebrafish, and they may act independently. However, the influence on morphology of gonad, liver, and gill induced by exposure to the mixture of EE2 and DBP was generally more potent than that by single exposure to EE2 or DBP, indicating the combined long-term harmful effects of EE2 and DBP on the development of zebrafish. Environ Toxicol Chem 2015;34:518-526. © 2014 SETAC.

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Section: Discussionmentioning

confidence: 74%

mentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

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Long‐term effects of binary mixtures of 17α‐ethinyl estradiol and dibutyl phthalate in a partial life‐cycle test with zebrafish (Danio rerio)

Chen

Liu

et al. 2015

Enviro Toxic and Chemistry

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“…BBP has bioconcentration factor values up to 462 in fish and can cause lethality at parts per billion concentrations (LC50 = 720 μg/L) . Other documented effects include alterations in behavior, vitellogenin induction as well as inhibition of growth, disruption of gonadal differentiation, and feminization …”

Section: Discussionmentioning

confidence: 99%

Fish and Seabird Gut Conditions Enhance Desorption of Estrogenic Chemicals from Commonly-Ingested Plastic Items

Coffin

Huang

Lee

et al. 2019

Environ. Sci. Technol.

115

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Plastic is ingested by over 100 bird species and 40 fish species. Once ingested, plastic may release endocrinedisrupting plastic additives in the animal; however, amounts transferred are poorly characterized. We exposed 16 commonly ingested plastic items to fish and seabird laboratory gut mimic models using the digestive enzyme pepsin at pH 2 and shook them for 16 h at either 28 °C (in saltwater) for fish or 40 °C (in freshwater) for seabirds. Gut liquid was then evaluated for estrogen receptor activity using an in vitro cell line, and plastic-additive concentrations were quantified using ultrahigh-performance liquid chromatography/tandem mass spectrometry. Both seabird (p < 0.0001) and fish gut conditions (p < 0.0001) significantly enhanced the biological estrogenicity of expanded polystyrene, polyethylene shopping bag, and polypropylene string relative to controls, resulting in up to a 10.6-fold increase in estrogenicity. Out of 12 plastic additives analyzed, bisphenol A (BPA) (204 ± 129%) and diethylhexyl phthalate (DEHP) (175 ± 97%) concentrations were significantly increased in seabird gut conditions relative to control and butylbenzyl phthalate (BBP) (132 ± 68%) was significantly increased in fish gut conditions relative to control. BPA, DEHP, and BBP did not adequately account for the increase in biological estrogenicity, suggesting that uncharacterized plastic additives may have been enhanced by gut conditions.

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“…Prenatal exposure to DBP has also been shown to significantly decrease serum testosterone levels in rats [38]. Another phthalate, diisononyl phthalate (DiNP), has been identified to disrupt sexual differentiation in European pikeperch (Sander lucioperca [39]). Widespread exposure reported in human epidemiological studies have linked phthalates with these reproductive impacts, as well as neurodevelopmental changes in infants and children [40][41][42][43][44], obesity [45], and diabetes in adolescents and adults [46].…”

Section: Introductionmentioning

confidence: 99%

Temporal and Spatial Evaluation of Mono(2-ethylhexyl) Phthalate (MEHP) Detection in Common Bottlenose Dolphins (Tursiops truncatus) from Sarasota Bay, Florida, USA

Dziobak

Balmer²,

Wells

et al. 2022

Oceans

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Phthalates are endocrine-disrupting chemicals added to plastics, personal care products, cleaning solutions, and pesticides. Extensive use has led to its exposure to wildlife, including common bottlenose dolphins (Tursiops truncatus) from Sarasota Bay, Florida, USA; however, there are gaps in knowledge regarding whether sample timing or geographic location influence exposure. Dolphins were evaluated for temporal and spatial variability in urinary mono(2-ethylhexyl) phthalate (MEHP) detection (2010–2019). Significant fluctuations in detectable MEHP concentrations were found across the dataset. All samples from 2014 and 2015 (n = 12) had detectable MEHP concentrations; thus, data were classified into cohorts to explore the significance of prevalent MEHP detection (“Cohort 1” (n = 10; 2010–2013), “Cohort 2” (2014–2015), and “Cohort 3” (n = 29; 2016–2019)). Compared to Cohorts 1 and 3, Cohort 2 had higher detectable MEHP concentrations (Dunn’s; p = 0.0065 and p = 0.0012, respectively) and a greater proportion of detectable MEHP concentrations (pairwise comparisons using Benjamini–Hochberg adjustments: p = 0.0016 and p = 0.0059, respectively). MEHP detection also varied across spatial scales. Dolphins with detectable MEHP concentrations had ranges primarily within enclosed embayments, while dolphins with nondetectable MEHP concentrations extended into open waters, potentially indicating geographically linked exposure risk. This study suggests that researchers and management agencies should consider a population’s ranging pattern, geographic habitat characteristics, and sample timing when assessing small cetacean health in relation to contaminant exposure.

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Impact of di-n-butyl phthalate on reproductive system development in European pikeperch (Sander lucioperca)

Cited by 9 publications

References 16 publications

Long‐term effects of binary mixtures of 17α‐ethinyl estradiol and dibutyl phthalate in a partial life‐cycle test with zebrafish (Danio rerio)

Long‐term effects of binary mixtures of 17α‐ethinyl estradiol and dibutyl phthalate in a partial life‐cycle test with zebrafish (Danio rerio)

Fish and Seabird Gut Conditions Enhance Desorption of Estrogenic Chemicals from Commonly-Ingested Plastic Items

Temporal and Spatial Evaluation of Mono(2-ethylhexyl) Phthalate (MEHP) Detection in Common Bottlenose Dolphins (Tursiops truncatus) from Sarasota Bay, Florida, USA

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